Evaluation of Adherence on Antihypertensive Use at X-Pharmacy Yogyakarta in 2009 Based on Medication Possession Ratio

  • RITA SUHADI UNIVERSITAS SANATA DHARMA

Abstract

World Health Organization reported that hypertension was in the top rank as global causes of death in 2009. Adherence to the antihypertensive medication reduced risks of various cardiovascular diseases. A cross-sectional study has been carried out to observe profile of the use of antihypertensive and to evaluate patient’s compliance based on Medication Possession Ratio (MPR) at X-Pharmacy Yogyakarta in 2009. Study subjects were the prescription of antihypertensive for patient regularly visits at least 3 times. The MPR was calculated as the ratio of the sum of the days supply of the prescription filled, excluding the latest prescription, divided by number of days filled. Results showed that the class and type of the most commonly prescribed antihypertensives based on the number of units and the highest mean units per prescription was the ACEI (captopril 25mg) and based on the frequency of prescribing was CCB (amlodipin 5mg). The use of generic drugs versus branded medicines 5.6 times in the units, 3.2 times more in the frequency of prescribing, and 1.7 times more generic drugs in mean units per prescription. There was no significant difference between the adherence of patients based on sex, with or without costsharing; as well as single or combination antihypertensive based on MPR (p > 0.05); mean MPR was 0.78 ± 0.15 (range 0.41-1.00); and as many as 50.00 0 had MPR > 0.8 and considered as adherent patients.

References

1. Setiati S and Sutrisna B. Prevalence of hypertension Without anti-hypertensive medications and its association with social demographic characteristics among 40 years and above adult population in Indonesia. Acta Med Indones-Indones J Intern Med. 2005. 37(1): 20-25.

2. Padwal R, Straus SE, McAlister FA. Evidence based management of hypertension, Clinical Review. 2001. 977-80.

3. WHO. Global health risks, mortality and burden of disease attributable to selected major risks. Geneva: WHO; 2009. 1-12,17.

4. Saseen JJ, MacLaughlin EJ. Hypertension in pharmacotherapy, a pathophysiologic approach.7th Ed, New York: Mc Graw Hill Co; 2008. 139-71.

5. Robertson TA, Cooke CE, Wang J S, Shaya FT, Lee HY. Effect of medication burden on persistent use of lipidlowering drugs among patients with hypertension. Am J Manag Care. 2008. 14(11):710-16.

6. McWilliams JM, Meara E, Zaslavsky AM, Ayanlan JZ. Differences in control of cardiovascular disease and diabetes by race, ethnicity, and education: US trends from 1999 to 2006 and effects of medicare coverage. Ann Intern Med. 2009. 150:505-15.

7 . Yoon J., Ettner SL.,C0st-sharing and adherence to antihypertensives for low and high adherers, Am J Manag Care. 2009. 15(11):833-40.

8. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, 1220 JL, et al. The seventh report of the Joint National Committee on prevention, detection,
evaluation, and treatment of high blood pressure. the JNC7 Report in JAMA. 2003. 289(19):2560-72.
Published
2011-04-30
How to Cite
SUHADI, RITA. Evaluation of Adherence on Antihypertensive Use at X-Pharmacy Yogyakarta in 2009 Based on Medication Possession Ratio. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 9, n. 1, p. 53-59, apr. 2011. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/327>. Date accessed: 25 feb. 2024.
Section
Articles