Prediction of Transdermal Transport Kinetics of Propranolol HCl by WinSAAM Program

  • LUCIA HENDRIATI UNIVERSITAS KATOLIK WIDYA MANDALA
  • AKHMAD KHARIS NUGROHO UNIVERSITAS GADJAH MADA

Abstract

Transdermal transport was an alternate to propranolol HCl delivery to overcome the low bioavailability by oral route. Kinetics of transdermal transport can be predicted by software WinSAAM. The aim of this research was to know kinetics of propranolol HCl transdermal transport with the present of enhancer oleic acid, propylene glycol and iontophoretics. Propranolol HCl transdermal transport was examined through the hairless rat as membrane on the vertical diffusion cell in the in vitro permeation. Enhancement methode used was oleic acid in propylene glycol and iontophoretics at varying concentrations. The donor phase contained 5 mg/mL propranolol HCl in citrate buffer, and the acceptor phase contained phosphate buffer saline at pH 7.4. Results of propranolol HCl transdermal transport analyzed by WinSAAM software. Parameters of transdermal transport were the rate of mass transfer from donor compartement to skin (Ka), available dose to transport (AD), and the rate of mass transfer from skin to acceptor compartement (KR).The results indicated that propranolol HCl transdermal transport with the present of enhancer can be explained by three compartement model and first order kinetics. Theoretically, value of AD influenced by oleic acid, interaction of oleic acid-iontophoretics and interaction of propylene glycol-iontophoretics. Value of Ka inliuenced by iontophoretics and interaction of oleic acid-propylene glycol-iontophoretics. Value of KR induenced by iontophoretics.

References

1. Rao PR, Reddya MN, Ramakrishna S, Diwana PV. Comparative in vivo evaluation of propranolol hydrochloride after oral and transdermal administration in rabbits. Eur J Pharm Biopharm. 2003. 56: 81-85.

2. Namdeo A and Jain NK. Liquid crystalline pharmacogel based enhanced transdermal delivery of propranolol hydrochloride. Int J Pharm. 2002. 82: 223-6.

3. Benson, HAE. Transdermal drug delivery: penetration enhancement techniques. Curr Drug Delivery. 2005. 2: 23-33.

4. Conjeevaram R, Chaturvedula A, Betageri GV, Sunkara G, and Banga AK. Iontophoretic in vivc transdermal delivery of beta-blockers in hairless rats and reduced skin irritation by liposomal formulation. Pharm Res. 2003. 20(9): 1496-1501.

5. Jaskari T, Vuorio M, Kontturi K, Urtti A, Manzanares JA, Hirvonen J. Controlled transdermal iontophoresis by ion-exchange iiber. J. Control Rel . 2000. 67: 179-90.

6. Nugroho AK, Della-Pasqua O, Danhof M, Bouwstra JA. Compartemental modeling of transdermal iontophoretic transport. in vitro model derivation and application. Pharm Res. 2004 21: 1974-84.

7. Rastogi SK and Singh J Passive and iontophoretic transport enhancementof insulin through porcine epidermis by depilatori‘es: permeability and fourier transform infrared spectroscopy studies. AAPS Pharm Sci Tech. 2003. 4(3).

8. lnal O, Kilicarskan M, Ari N, Baykara T. In vitro and in vivo transdermal studies of atenolol using iontophoresis. Acta Poloniae Pharmaceutica-Drug Research. 2008. 65 (1): 29-6.

9. Wang Y, Fan Q, Song Y, and Michniak B. Effect of fatty acid and iontophoresis on the delivery of midrodrine hydrochloride and the structure of human skin. Pharm Res. 2003. 20(10): 1612-8.


10. Schunn CD and Wallach D. Evaluating goodness of {it in comparison of models to data. Pitsburgh: University of Pittsburgh; 2006. 7-23.

11. Kumar R and Philip A. Modified transderrnal technologies : Breaking the barrier of drug permeation Via the skin. Trop J Pharm Res. 2007. 6(1): 633-44.

12. Trommer H and Neubert RHH. Overcoming the stratum corneum : the modulation of skin penetration. Skin Pharmacol Physiol. 2006.19: 106-121.

13. J iang SJ and Zhou XJ. Examination of the mechanism of oleic acid induced percutaneous penetration enhancement: an ultrastructural study. Biol Pharm Bull. 2003. 26(1): 66-8.
Published
2011-04-30
How to Cite
HENDRIATI, LUCIA; NUGROHO, AKHMAD KHARIS. Prediction of Transdermal Transport Kinetics of Propranolol HCl by WinSAAM Program. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 9, n. 1, p. 60-66, apr. 2011. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/328>. Date accessed: 27 dec. 2024.
Citation Formats
Issue
Vol 9 No 1 (2011): JIFI
Section
Articles
License

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.