Antimalarial Activity and Phytochemical Screening of Secondary Metabolites from Heartwood and Root Bark of Artocarpus Carmmsi Blanco (Moraceae)

  • ALIEFMAN HAKIM UNIVERSITAS MATARAM
  • EKA JUNAIDI UNIVERSITAS MATARAM
  • BAIQ FARA DWI RANI SOFIA UNIVERSITAS MATARAM
  • YUNITA ARIAN SANI ANWAR UNIVERSITAS MATARAM

Abstract

Malarial parasite, Plasmodium, has been reported resistant to commonly used antimalarial drugs, such as chloroquin. Plants Artocarpus genus are known to have high content of flavonoids. One of interesting bioactivities of Artocarpus flavonoids is their antimalarial activity. This research is to investigate the potency of secondary metabolites in the heartwood and root bark of Artocarpus camansi Blanco as an antimalarial agent. Antimalarial activity from methanol extract of heartwood and roots bark of A. camansi were tested in vitro to Plasmodium falciparum SD7 (strain sensitive to chloroquin) and W2 (strain resistant to chloroquin) The extracts were also phytochcmically screened for compounds. The result showed that the methanol extract of heartwood and root bark of A , camansi Blanco inhibited the growth of Plasmodium falciparum 3D7 strain With IC50 values of 1.84 µg/mL and 32.13 µg/mL . respectively; While similar antimalarial activity test to Plasmodium falciparum W2 strain showed IC50 valucs of 8.11 µg/mL and 17.10 µg/mL, respectively. Phytochemical screening indicated that the heartwood and root bark of A. camansi Blanco contain flavonoids, terpenoids, and tannin, while coumarin and saponins are present only in the root bark of A. camansi Blanco.

References

1. Sutamihardja A, Krisin, Wangsamuda S, Rogers WO. Buku Panduan Pelatihan Diagnosa Mikroskopi Malaria. Departenien Parasitologi Medis US NAMRU-2 Jakarta. 2009.

2. Jaret FM. Studies in Artocarpus and allied genera, III. A revision of Artocarpus subgenus Artocarpus. Journal of Arnold Arboretum. 1959. Vol XL, No. 2.

3. Jaret FM. Studies in Artocarpus and allied genera, IV A revision of Artocarpus subgenus Pseudojaca. Journal of Amold Arboretum. 1960. Vol XLI, No. 1 dan 2.

4. Achniad SA, Hakim EH, Makmur L, Mujahidin D, Marlina E, Gihisalberti EL. Artocarpin dan Heteroflavanon A, Dua Senyawa Flavanoid Bioaktif dari Artocarpus champeden, Proc ITB. 1998. 30-1.

5. Widyawaruyanti A, Subehan, Kalauni SK. Awale S, Nindatu M, Zaini NC, Syafruddin D, Asih PBS, Tezuka Y, Kadota S. New prenylated flavones from Artocarpus champeden, and their antimalarial activity in vitro, Journal Natural Medicine. 2007. 61: 410-3.


6. Boonlaksiri C, Oonanant W, Kongsaeree P, Kittakoop P, Tanticharoen M, Thebtaranonth Y An antimalarial stilbene from Artocarpus integer. Phytochernistry. 2000. 54: 415-7.

7. Khan MR, Ornoloso AD, Kihara M. Antibacterial activity ofArtocarpus heterophyllus, Fitoterapia. 2003. 74: 501-5.

8. Jayasinghe L, Balasooriya BAIS, Padmini WC, Hara N, Fujimoto Y, Geranyl chalcone derivatives with antifungal and radical scavenging properties from the leaves of Artocarpus nobilis, Phytochemistry. 2004. 65: 1287-90.

9. Fang SC, Hsu CL, Yen GC. Anti-inflammatory Effects of Phenolic Compounds Isolated from the Fruits of Artocarpus heterophyllus. J Agric Food Chem. 2008. 56: 4463-8.

10. Zheng ZP, Chen S, Wang S, et, al. Chemical Components and Tyrosinase Inhibitors from the Twigs of Artocarpus heterophyllus, J Agric Food Chem. 2009. 57: 6649-55

11. Ciulei J. Metodologi for Analisis of Vegetables and Drugs. Faculty of Pharmacy. Bucharest Rumania. 1984. 11-26.

12. Trager W, Jensen JB. Human Malaria Parasites in Continues Culture. Science. 1976, 193: 673-6.

13. Johnson J, Waters NC. Malaria SYBR Green I-based Floresencece Assay. Silver Spring. Maryland. 2006.

14. Kohler I. In Vitro Antiplasmodial Investigation of Medicinal Plants frorn El Savador. Z. Naturforsch. 2002. 57c: 277-8.
Published
2010-09-30
How to Cite
HAKIM, ALIEFMAN et al. Antimalarial Activity and Phytochemical Screening of Secondary Metabolites from Heartwood and Root Bark of Artocarpus Carmmsi Blanco (Moraceae). JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 8, n. 2, p. 131-135, sep. 2010. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/348>. Date accessed: 26 apr. 2024.
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Vol 8 No 2 (2010): JIFI
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