Sintesis Hidrogel Superabsorben Polietilen Oksida-Alginat dengan Teknik Radiasi Gamma dan Karakterisasinya

  • ERIZAL ERIZAL PUSAT APLIKASI TEKNOLOGI ISOTOP dan RADIASI PATIR-BATAN
  • I WAYAN REDJA UNIVERSITAS PANCASILA

Abstract

Abstract: In order to develop the applications of radiation for biomaterial preparation, a non-toxic superabsorbent has been synthesized. A series of superbasorbent hydrogel were prepared from aqueous solution containing 5% polyethylene oxide (PEO) with different concentration of alginate (0.5-2.0%) were irradiated at the doses of 20, 30, and 40 kGy by gamma radiation.The gel fraction, swelling kinetics and the equilibrium degree of swelling (EDS) of the hydrogels were studied, It was found that the incorporation of even 2% alginate (sodium salt) increased the EDS of the hydrogels from 20g/g to 320 g/ g. At a dose of 20 kGy, PEO-alginat hydrogels with high gel fraction (  ̴ 8O%) and very high EDS (  ̴ 320 g/g) were obtained. The hydrogels were also found to be sensitive to the ionic solution of NaCl. The PEO-alginate hydrogels could be considered as candidate biomaterials in health care.

References

1. Davis LC, Novais SM, Martin ND. Detoxification of olive oil using superabsorbent. Environ Technology. 2004.(25):59-100.

2. Flores G, Herraz M, Ruiz DC. Use of superabsorbent polymer for the preconcentration of volatile compound from complex mixtures. J Sep Sci. 2006. 29(17):267- 77.

3. Hosseinzadeh H, Pourjavavdi A, Zohuriaan M. 2-Hydrolized crosslinked kappa carrageenan-g- PAAM as a novel smart superabsorbent hydrogel with low salt sensitivity. J Biomater Sci, Polym Ed. 2004.15(12):l499-511.


4. Paulino AT, Guilorme, Reis A, Compesse GM, Muniz EZ, Nozaki J. Removal of methylene blue from an aqueous media using superabsorbent hydrogel supported on modified polysaccharide. J Colloid Interface Sci. 2006.301(1):55-62.

5. Sannino A, Esposito A, De Rosa A, Cozzolino A, Ambrosio L, Nicolas L. Biomedical application of a superabsorbent hydrogel for body Water elimination in the treatment of edemas. J Biomed Mater Res A. 2003.67(3) :1016-1024.

6. Khoylou F, Naimian F. Radiation synthesis of superbabsorbent polyethylene oxide/tragacanth hydrogels. Radiation Physic and Chemistry. 2009. 78:195-8.

7. Michael MC, Zhang F, Jhon JK, James WG. Stability PEO in matrix tablets prepared by hot-melt extrusion. Biomaterials. 2007.23(21):4241-8.

8. Tamai T, Matsukawa K, Inou H, Imura T, Nishikawa N. Preparation of hydrogel by crosslinking of polyethylene oxide derivatives. Science and Industry. 2000.34(9):458-67.

9. Lopina ST, Wu G, Merrile W, Griffith CL. Hepatocyte culture on carbohydrate-modified star polyethylene oxide hydrogels. Biomaterials. 2005.17:559-69.

10. Bianca C, Magazu S, Maisano. Synthesis of polyethylene oxide hydrogels by electron radiation. J of Applied Polymer Science. 2006. 102:820-4.

11. Sperling LH. Interpenetrating polymer networks and related materials. Plenum Press. 1981. Chpt. 1.

12. Tombs M, Estephen EH. An introduction to polysaccharide biotechnology. London: Taylor & Francis; 1998. p. 123-34.

13. Rosiak JM, Ulanski P, Pajewski LA, Yosihii F, Makuuchi K. Radiation formation of hydrogels for biomedical purposes, some remarks and comments. Radiat Phys Chem. 1995 .46:161-8.

14. Khoylou F, Naimian F. Radiation synthesis of superabsorbent polyethylene oxide/tragacanth hydrogel. Radiation Physic and Chemistry.2009, (78):195-198.

15. Badan Standarisasi Nasional. SNI 16-6363-2000: Pembalut wanita. Jakarta. 2000.

16. Soerens, Dave A, Malik S. PATENT 6967261 (USA).

17. Sanju F, Manmohan K, Lalit V Radiation synthesis of superbasorbent poly(acrylic acid)-carrageenan hydrogels. Radiation Physio and Chemistry. 2004. (69):481-6.

18. Tomar RS, lndu G, Reena S, Nagpal AK. Synthesis of poly(acrylamide-co-acrylic acid)-based superabsorbent hydrogels by gamma radiation: study of swelling behaviour and network parameters. Designed Monomers and Polymers. 2007. 10(1):49-66.
Published
2010-04-30
How to Cite
ERIZAL, ERIZAL; REDJA, I WAYAN. Sintesis Hidrogel Superabsorben Polietilen Oksida-Alginat dengan Teknik Radiasi Gamma dan Karakterisasinya. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 8, n. 1, p. 11-17, apr. 2010. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/359>. Date accessed: 24 feb. 2024.
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Articles