Isolasi Senyawa Aktif dari Ekstrak Hipokotil Sarang Semut (Myrmecodia pendens Merr. & Perry) sebagai Penghambat Xantinoksidase

  • PARTOMUAN SIMANJUNTAK LEMBAGA ILMU PENGETAHUAN INDONESIA
  • FANNY FANNY LEMBAGA ILMU PENGETAHUAN INDONESIA
  • MUHAMMAD AHKAM SUBROTO LEMBAGA ILMU PENGETAHUAN INDONESIA

Abstract

Medicinal plant called “sarang semut”, Myrmecodia pendens Merr. & Perry (Rubiaceae), is an epiphyt plant traditionally used in Papua for healing various diseases such as hyperuricemia, rheumatic, and cancer. A chemical compound recognized as xanthinoxidase inhibitor has been isolated from n-buthanol fraction of the plant extract. The isolation was carried out by column chromatography (SiO2, CHCI3-MeOH = 5:1-1:1) and the purification Was conducted using high pressure liquid chromatography (RP, C-18; MeOH-water = 5 : 1). The activity test for Xanthinoxidase inhibitor Was performmed by using modilied Noro method. The pure compound showed xanthinoxidase inhibitor activity of IC50  at 79,77%.

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Published
2010-04-30
How to Cite
SIMANJUNTAK, PARTOMUAN; FANNY, FANNY; SUBROTO, MUHAMMAD AHKAM. Isolasi Senyawa Aktif dari Ekstrak Hipokotil Sarang Semut (Myrmecodia pendens Merr. & Perry) sebagai Penghambat Xantinoksidase. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 8, n. 1, p. 49-54, apr. 2010. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/366>. Date accessed: 05 nov. 2024.
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Vol 8 No 1 (2010): JIFI
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