Formulasi Edible Film Ekstrak Daun Sirih (Piper betle L.) sebagai Antihalitosis

  • MOCH FUTUCHUL ARIFIN UNIVERSITAS PANCASILA
  • LILIEK NUR HIDAYATI UNIVERSITAS PANCASILA
  • SYARMALINA SYARMALINA UNIVERSITAS PANCASILA
  • RENSY RENSY UNIVERSITAS PANCASILA

Abstract

Halitosis (bad breath) is the most complained problem among mouth and teeth health. The source of halitosis are volatile sulfur compounds produced by Streptococcus mutans from degradation of food debris. Sirih leaves (Pqaer betle L.) are traditionally used as mouth antiseptic for its volatile oil. The aim of this research was to formulate sirih extract into an edible film. The leaves were macerated with 96% ethanol for 24 hours, resulting to an extract with minimum inhibitory concentration (MIC) on Streptococcus mutans of 8.49x10-3 g/ml. The extract with strength quadruple of the MIC, or equal to 0.92% povidone iodine, was formulated using 23 factorial design. Com starch, hydroxypropyl methylcellulose (HPMC) and sorbitol were independent variables and drying time, moisture, hlm thickness, disintegrating time, and iilrn strength were the dependent ones. The results showed that HPMC significantly fastened the drying time, decreased the moisture, and lengthened the disintegrating time. Sorbitol significantly lengthened the drying time, increased the moisture, and strengthened the film, while corn starch decreased the moisture and lengthened the disintegrating time. Optimation of the formula ingredients using contour plot superimposed cannot be determined due to edible film disintegrating time that was out of comparative interval.

References

1. Departemen Kesehatan Republik Indonesia. Bau mulut tak sebatas urusan kosmetik. Jakarta: Pusat Data dan lnformasi Depkes RI; 2008. Diambil dari http://www. depkesgo.id/index.articles&task=viewarticle&artid=332<emid=3. Diakses tanggal 29 November, 2008.

2. Suprihati IT, Sunarminingsih R, Ristanto. Pengaruh teknik penyimpanan daun sirih sebagai obat kumur terhadap akumulasi plak gigi dan pertumbuhan bakteri [Laporan Penelitian]. Yogyakarta: Universitas Gajah Mada.1990.

3. Anonim. Cara cepat terhindar dari bau mulut. 2008. Diambil dari: http://www.Decha Care.com/artikel I/2008/350.htm. Diakses tanggal 18 November, 2008.

4. Soedibyo M. Alam sumber kesehatan. Jakarta: Balai Pustaka; 2000. hal. 347-9.

5. Wade A, Weller PJ (editors). Handbook of pharmaceutical excipient. 2nd ed. London; The Pharmaceutical Press; 1994. p. 78-80, 191-3, 304-5, 411-3, 477-9, 483-7, 500-5.

6. James S, James CB (ed). Film coatings and film forming materials: evaluation to generic drugs and generic equivalency. In: Encyclopedia of pharmaceutical technology. New York: Marcel Dekker. Inc.; 1990. p. 1-5

7. Bolton S. Pharmaceutical statistic. 2nd ed. New York: Marcel Dekker. Inc.; 1999. p. 308-10, 317-9.

8. Balitro. Teknologi penyiapan simplisia terstandar tanaman obat. Diambil dari: http://Balitro/Tanaman obat. Diakses tanggal 29 Januari 2009.

9. Departeman Kesehatan Republik Indonesia. Materia rnedika Indonesia. Jilid IV. Jakarta: Direktorat Jendaral Pengawasan Obat dan Makanan. 1980. hal. 92-9.

10. Lennette E. Manual of clinical microbiology. 2nd ed.Washington DC; l974. p. 410- 1

11. Kroctha J. Edible coatings and tilm to improve food quality. Pennsylvania: Technomic Publishing Co. Inc.; 1994. p. 1-8, 230.

12. Badan Standarisasi Nasional. SNI 01-3 547-1994. Mutu dan cara uji kembang gula. Jakarta: Badan Standar Nasional. 1994. hal. 1-2.

13. Armstrong NA. Pharmaceutical experimental design and interpretation. 2nd ed. New York: Taylor and Francis Group; 2006. p. 83-133.

14. Stephen JM. Radiolabeled antibodies and peptides. “Textbook of radiopharmacy: theory and practice”, 3rd ed. Edited by Charles B. Sampson. Amsterdam: Gordon and Breach Science Publishers; 1999. p. 63-82.
Published
2010-04-30
How to Cite
ARIFIN, MOCH FUTUCHUL et al. Formulasi Edible Film Ekstrak Daun Sirih (Piper betle L.) sebagai Antihalitosis. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 8, n. 1, p. 61-68, apr. 2010. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/371>. Date accessed: 25 may 2025.
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Vol 8 No 1 (2010): JIFI
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