Formulasi Gel Pengelupas Kulit Mati yang Mengandung Etil Vitamin C dalam Sistem Penghantaran Macrobead®

  • MARLINE ABDASSAH UNIVERSITAS PADJADJARAN
  • TAOFIK RUSDIANA UNIVERSITAS PADJADJARAN
  • ANANG SUBGHAN UNIVERSITAS PADJADJARAN
  • GUSTIN HIDAYATI UNIVERSITAS PADJADJARAN

Abstract

To recover good appearance of skin, dead skin cells should be removed, among others by using exfoliating agent, and to preserve the fresh skin ethyl vitamin C could be used as an antioxidant. Formulation and evaluation of skin exfoliating gel containing ethyl vitamin C in Macrobead® delivery system, using acrylates copolymer and carboxy vinyl polymer as gel bases have been carried out. The gel evaluation included physical evaluation and safety examination. The results showed that ethyl vitamin C could be trapped into Macrobead® system with good absorption inthe ratio of active content and Macrobead® of 3:4. Based on the physical evaluation of the gel formula, it was found that formula with acrylates copolymer base has altered the consistency and homogenity of gels, but not the formula with carboxy vinyl polymer base. Gels using carboxy vinyl polymer showed good physical stability for28 days of storage. The safety evaluation indicated that the preparation was safe to be used for it did not cause irritation on consumers skin. The examination showed that the preparation could exfoliate dead skin cells and thus freshen the users’ skin effectively.

References

1. Wasitaatmadja SM. Penuntun ilmu kosmetik medik. Jakarta: UI Press; 1997. hal. 197-9.

2. Brown A. What is eXfoliation?. Diambil dari http://spas.about.com/od/spatreatmentbasics/a/exfoliation. htm. Diakses tanggal 26 Desember 2007

3. Goldfaden. Exfoliation restores a youthful appearance. 2006. Diambil dari http://www.cosmesisskincare.com/skin.html. Diakses tanggal 25 Desember 2007.

4. Lee Z, Beom ENB-VCE. 3-O-ethyl aseorbyl ether. Korea: CHEMLAND Co. Ltd; 2006.


5. Su S. 2005. Ethyl ascorbic acid. Diambil dari http://www. infochems.com/market/general_content.asp?i dX=4506&ctype=sell<ype=list&list=all&inX=E&search__option=n&search_keyword=n&lorder=regi_ date&page=1. Diakses tanggal 22 Desember 2007 .

6. Ansel HC.,Pengantar bentuk sediaan farmasi. Edisi ke-4. Jakarta: UI-Press; 1989. hal. 145-8, 390-1, 490-4.

7. Fifield SC, Ashley JW. Reinsdorf H, Farber T, Dennard L, Lefebvre K. 2006. Macrobead. Diambil dari http://tarr.uspto.gov/servlet/tarr‘?regser=serial&entry=78486067. Diakses tanggal 22 Desember 2007.

8. Saxena S, Sergio N. Polymeric porous delivery systems: Polytrap® and Microsponge®. In Meyer R. (ed), Delivery system handbook for personal care and cosmetic products. The Netherlands: William Andrew Inc; 2005. p. 334-7.

9. AMCOL HBS. Delivery system. 2007. Diambil dari http://www.incosmetics.com/ExhibitorLibrary/169/ DeliverySystems100604.pdf. Diakses tanggal 22 Desember 2007.

10. Martin A, James S, Arthur C. _ Farmasi fisik. Edisi Ketiga. Jakarta: UI-Press; 1993. hal.. 1170.

11. Lazarus J , Bernard I. Semipadat. Dalam Lachman L, Herbert AL, Joseph LK. Teori dan praktek farmasi industri. Edisi ke-3. Jakarta: UI-Press; 1994. hal. 1091-145.

12. Mammone T, Gan DC. Methods of exfoliation using N-acetyl glucosamine. United States Patent. 2002. No.6413525.

13. Harry’s cosmeticology. 6th ed. New York: Chemical Publishing Co. Inc; 1973.
Published
2009-09-30
How to Cite
ABDASSAH, MARLINE et al. Formulasi Gel Pengelupas Kulit Mati yang Mengandung Etil Vitamin C dalam Sistem Penghantaran Macrobead®. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 7, n. 2, p. 105-111, sep. 2009. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/382>. Date accessed: 05 nov. 2024.
Section
Articles