Aktivitas Antikarsinogenesis Ekstrak Etanol Daging Buah Mahkota Dewa pada Mencit yang Diinduksi 7,12-Dimetilbenz(a)antrasena

  • YANDI SYUKRI UNIVERSITAS ISLAM INDONESIA
  • SAEPUDIN SAEPUDIN UNIVERSITAS ISLAM INDONESIA

Abstract

Mahkota dewa (Phaleria macrocarpa Boerl.) was used empirically for treatment of any kind of diseases, including cancer. The aim of this research is to explore the carcinogenesis inhibition effect of mahkota dewa epicarp extract. The effect was examined using 7,12-dimethylbenz(a)anthracene (DMBA) induced new born mice which Were divided into five groups. All groups received 0.25 mg single intraperitoneal injection of DMBA, except group of normal control. The extract was tested onto three different groups of the mice at the age of 28 days which Was separated from their parental with the doses of 6.25 mg, 12.5 mg, and 25 mg for 16 Weeks and one group Was used as negative control. Anticarcinogenic effect of the extract was evaluated after 16 Weeks by observing the histopathology and total number of all types of neoplasm in hepar, kidney, lung, gastric, intestine, and lymphatic tissue. The result showed that the extract at 6.25 mg, 12.5 mg, and 25 mg decreases carcinogenesis event by 50%, 83%, and 100% , respectively, compared with negative control. In conclusion, the dose of 25 mg extract improved several organs carcinogenesis than other dose, and thereby can be developed as a potential anticancer agent.

References

1. King RJB. Cancer biology. 2nd ed. London: Pearson Education Limited; 2000.

2. Tjindarbumi D, Mangunkusumo R. Cancer in Indonesia, present and future. lpn Clin Oncol. 2002. (1): 10-15.

3. Alberts B, Bray D, Lewis J, Roberts K, Watson JD. Molecular biology of the cell. 3rd ed. New York and London: Garland Pub1 Inc; 1994.p.1255-83.

4. Mahendra B. 13 Jenis tanaman obat ampuh. Jakarta: Penebar Swadaya; 2005. hal.67.


5. Puspaningsih DD, Soegihardjo CJ. Uji toksisitas akut buah matang mahkota dewa (Phaleria macrocarpa Boerl.) terhadap larva Artemia Salina Leach. Beserta profil kromatografi fraksi paling aktif [skripsi]. Yogyakarta: Prodi Farmasi UII; 2003.

6. Sukemti, Soegihardjo CJ. Uji toksisitas akut buah mentah mahkota dewa (Phaleria macrocarpa Boerl.) terhadap larva Anemia Salina Leach. beserta profil kromatografi fraksi paling aktif [skripsi] Yogyakarta: Prodi Farmasi UH; 2004.

7. Triastuti A. Efek antiangiogenik ekstrak etanol buah mahkota dewa (Phaleria macrocarpa Boerl.) pada membran korio alantois (CAM) embrio ayam yang terinduksi bFGF [Laporan Penelitian]. Yogyakarta: Prodi Farmasi UII; 2006.

8. Departemen Kesehatan Rl. Farmakope Indonesia.Edisi IV. Jakarta: Departemen Kesehatan RI; 1995.

9. Della PG, Terracini B. Chemical carcinogenesis in infant animals. Prog Exp Tumor Res. 1969. (11):334.

10. Toth B. A critical review of experiments in chemical carcinogenesis using newborn animals. Cancer Res. 1968.(28):727.

11. Constantinou Al, Mehta R, Husband A, Phenoxodiol. A novel isoflavone derivative, inhibits 7,12- dimethylbenz(a)anthracene (DMBA)-induced mammary carcinogenesis in female Sprague- Dawley Rats. European J oumal of Cancer. 2003. (39):1012-18.

12. Mun’im A, Andraj ati R, Susilowati H. Uji hambatan tumorigenesis sari buah merah (Pandanus conoideus Lam.) terhadap tikus putih betina yang diinduksi 7,12- dimetilbenz(a)antrasen. Majalah Ilmu Kefarmasian. 2006.(3):153-61.
Published
2008-09-30
How to Cite
SYUKRI, YANDI; SAEPUDIN, SAEPUDIN. Aktivitas Antikarsinogenesis Ekstrak Etanol Daging Buah Mahkota Dewa pada Mencit yang Diinduksi 7,12-Dimetilbenz(a)antrasena. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 6, n. 2, p. 63-67, sep. 2008. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/400>. Date accessed: 21 june 2024.
Section
Articles