Activity Tests of Bioactive Material of Salung Leaf (Psychotria viridiflora Reinw. Ex. Blume) against Salmonella thypi Bacteria In Vitro And In Vivo

  • SALNI SALNI UNIVERSITAS SRIWIJAYA
  • HANIFA MARISA UNIVERSITAS SRIWIJAYA
  • HARMIDA HARMIDA UNIVERSITAS SRIWIJAYA

Abstrak

Telah dilakukan uji aktivitas bahan bioaktif dari daun Salung (Psychotria viridiflora Reinw. ex. Blume) terhadap bakteri Salmonella thypi secara in vitro dan in vivo. Bahan bioaktif diperoleh dari proses maserasi dan dilanjutkan dengan fraksinasi secara fraksinasi cair-cair (FCC), Pengujian aktivitas antibakteri dilakukan secara in vitro untuk menentuan nilai konsentrasi hambat minimum (KHM) dan pengujian secara in vivo pada tikus putih (Rattus norvegicus) untuk mengetahui kemampuan bioaktif menyembuhkan penyakit diare yang diinfeksi dengan Salmonella typhi. Perlakuan bahan bioaktif yang diberikan 0, 10, 50 dan 100 mg/kgbb. Hasil penelitian menunjukkan bahwa KHM bahan bioaktif dari daun salung terhadap bakteri Salmonella typhi yaitu 250 μg/ml. Bahan bioaktif pada dosis 10 mg/kgbb dan 50 mg/kg mampu menurunkan jumlah koloni bakteri menjadi 4,14x106 dan 5,4x105 cfu/g, lebih sedikit dibanding kontrol 5,04 x 106 cfu/g. Bahan bioaktif 100 mg/kgbb dapat menurunkan populasi bakteri Salmonella typhi sampai nol setelah 12 hari pengobatan. Kemampuan bahan bioaktif 100 mg/kgbb sama dengan kontrol positif kloramfenikol 10 mg/kgbb.

Diterbitkan
2018-06-07
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SALNI, SALNI; MARISA, HANIFA; HARMIDA, HARMIDA. Activity Tests of Bioactive Material of Salung Leaf (Psychotria viridiflora Reinw. Ex. Blume) against Salmonella thypi Bacteria In Vitro And In Vivo. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 14, n. 1, p. 13-18, june 2018. ISSN 2614-6495. Tersedia pada: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/41>. Tanggal Akses: 10 aug. 2025
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Terbitan
Vol 14 No 1 (2016): JIFI
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