Penetapan Simultan Kadar Fenilpropanolamin Hidroklorida dan Klorfeniramin Maleat dalam Tablet secara Spektrofotometri

  • FARIDAH FARIDAH UNIVERSITAS PANCASILA
  • NOVI YANTIH UNIVERSITAS PANCASILA
  • NETTY HERAWATI UNIVERSITAS PANCASILA

Abstract

Simultaneous determination of phenylpropanolamine hydrochloride and chlorpheniramine maleate in tablets by spectrophotometry was carried out. The method is based upon total absorption of the two compounds in a mixture which can be applied to quantify each ofthe component. The absorption of phenylpropanolamine hydrochloride and chlorpheniramine maleate in 0.1 N hydrochloric acid were measured at the maximum Wavelength of phenylpropanolamine hydrochloride (256.7 nm) and that of chlorpheniramine maleate (262.6 nm), with a correlation coefficient of 0.999. A high precision could be obtained as shown by the CV of 0.2139-0.4962% for phenylpropanolamine hydrochloride and 0.3182- 0.5289% for chlorpheniramine maleate, While the recoveries ofphenylpropanolamine hydrochloride and chlorpheniramine maleate were 99.93% ± 0.43% and 99.76% ± 0.39%, respectively. The proposed method is simple, with a high accuracy and suitable for the simultaneous determination ofphenylpropanolamine hydrochloride and chlorpheniramine maleate in tablets, Without prior separation.

References

1. Sulistia GG, Rianto S, Frans DS, Purwatyastuti, Nafrialdi. Farmakologi dan terapi. Edisi IV. Jakarta: Fakultas Kedokteran Universitas Indonesia; 1995. hal. 252, 487-93.

2. Tan HT, Rahardja K. Obat-obat penting. Edisi V Jakarta: Direktorat Jenderal Pengawasan Obat dan Makanan; 2002. hal. 115, 773, 765.

3. Departernen Kesehatan Republik Indonesia. Farmakope Indonesia. Edisi IV. Jakarta: Direktorat Jendral Pengawasan Obat dan Makanan; 1995. hal. 135-36, 293.

4. United States Pharmacopeia Convention. The United States pharmacopeias 29. The National Formulary 24. Rockville: United States Pharmacopeial Convention Inc; 2006. p. 486,782
5. United States Pharmacopeia Convention. The United States pharmacopeias 28. The National Formulary 23. Rockville: United States Pharmacopeial Convention Inc; 2005. p. 448,1545-56.

6. British Pharmacopeias Commision. British pharmacopoeia Vol I and II. London: Her Majesty’s Stationery Office; 2003. p. 454- 5,1471-2.

7. Moffat AC. Clarke’s isolation and identification of drug. 2nd ed. London: The Pharmaceutical Press; p. 456-7, 895-6.

8. Roth HJ, Blaschke G. Analisis farmasi. Diterjemahkan oleh Kisman S, Ibrahim S. Yogyakarta: Gajah Mada University Press; 1988. hal. 373-9.

9. Panda SK, Sharma AK. Simutaneous spectrophotometric estimation of phenylpropanolamine HCl, bromhexine HCl, and chlorpheniramine maleate. Indian J of Pharm Sci. 1999.61(2):116-8.

10. Wade A, Weller PJ. Handbook of pharmaceutical excipients. 2nd ed. London: The Pharmaceutical Press; 1994. p. 84, 280, 424, 483.

11. Schefler WC. Statistik untuk biologi, farmasi, kedokteran dan ilmu yang beitautan. Diterjemahkan oleh Suroso. Bandung: Penerbit ITB Press; 1987. hal. 71-103.
Published
2008-04-30
How to Cite
FARIDAH, FARIDAH; YANTIH, NOVI; HERAWATI, NETTY. Penetapan Simultan Kadar Fenilpropanolamin Hidroklorida dan Klorfeniramin Maleat dalam Tablet secara Spektrofotometri. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 6, n. 1, p. 29-34, apr. 2008. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/417>. Date accessed: 26 apr. 2024.
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Vol 6 No 1 (2008): JIFI
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