Formula Optimization of Fast Disintegrating Tablet (FDT) of Centella asiatica (L.) Urb. Ethanolic Extract
Abstract
It has been proven that Centella asiatica (L.) Urb. herbs have an antioxidant activity that make it possible to used in preventing degenerative illness. Centella asiatica (L.) extract has been formulated to fast disintegrating tablet (FDT) dosage form. The aims of this study are to find the optimum formula of FDT of Centella asiatica (L.) Urb. The simplex lattice design method with 3 factors (which are mannitol as diluents, crospovidone as superdisintegrant and povidone as binder) and 2 levels of each was used. Centella asiatica (L.) Urb. extract was produce from maceration process using ethanol-water in ratio 75%:25% as a solvent. Direct compress method was used to produce the FDT. The results show that the optimum composition between excipients FDT formula could be reached, which fullfiled the physical properties parameter which are the hardness, friability and disintegration time of FDT.
References
2. Brinkhaus, B., Lindner, M., Schuppan, D., and Hahn, E. G. Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica, Phytomedicine. 2000. 7(5):427–448.
3. Departemen Kesehatan Republik Indonesia. Farmakope Herbal Indonesia, edisi I, Jakarta, 2008. p 109-115, 171-175, 182-183.
4. Lestari, A, Fudholi A, Nugroho A, Setyowati E, Pengaruh Purifikasi n-Heksana pada Serbuk Simplisia terhadap Kadar Asiatikosida, Penangkapan Radikal Bebas dan Kadar Fenol Total Ekstrak Etanolik Herba Pegagan (Centella asiatica (L.) Urban), Jurnal Ilmu Kefarmasian Indonesia. 2015. 13(1), 10-16.
5. Chandrasekhar, R., Hassan, Z., AlHusban, F., Smith, A. M. and Mohammed, A. R. The role of formulation excipients in the development of lyophilised fast-disintegrating tablets. European Journal of Pharmaceutics and Biopharmaceutics. 2009. 72(1):119–129.
6. Katsuno, E., Tahara, K., Takeuchi, Y. and Takeuchi, H. Orally disintegrating tablets prepared by a co-processed mixture of micronized crospovidone and mannitol using a ball mill to improve compactibility and tablet stability, Powder Technology. 2013. 241:60–66.
7. Hirani, J. J., Rathod, D. A., and Vadalia, K. R. Orally Disintegrating Tablets: A Review, Tropical Journal of Pharmaceutical Research. 2009. 8(2):161–172
8. Hsu, A. F. dan Han, C. 2005, Oral disintegrating dosage forms, diakses pada 24 Februari 2017, http://www.freepatentsonline.com/y2005/0147670.html.
9. Velmurugan, S. and Vinushitha, S. Oral Disintegrating Tablets : An Overview, International Journal of Chemical and Pharmaceutical Scences. 2010. 1(II):1–12.
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