Specificity of Mercury Detecting Reagents for Skin Lightening Creams

  • Liliek Nurhidayati UNIVERSITAS PANCASILA
  • Titiek Martati UNIVERSITAS PANCASILA
  • I Wayan Redja UNIVERSITAS PANCASILA
  • Nofanti Sandra UNIVERSITAS PANCASILA

Abstract

Inorganic mercury compound have been used for long time in cosmetics preparations for its skin lightening effect. The used of mercury in cosmetics has been prohibited as stipulated in the decision of the BPOM RI (Head of the Food and Drug Supervisory Agency) No.HK.00.01.432.6147. Based on health department research from various countries, there are a number of skin lightening products containing mercury between 660-57.000 μg/kg. People needs a quick and easy way to detect mercury in a lightening cream, so that people can test the safety of cream that used. One alternative that can be used to detect mercury in skin lightening cosmetics is using detecting reagents. The aim of this study was preparation of specific and sensitive mercury detecting reagents. The detecting reagents consisted mixtures of diphenylcarbazone and acetic acid in 96% of ethanol. The specificity test is performed by adding diphenylcarbazone solution into a lightening cream containing whitening agents such as mercury, hydroquinone, bangkuang extract and mixture of these substances. Assay was also performed on simulated cream that contained mercury, zinc oxide, bismuthsubnitrate, and mixture of mercury, zinc oxide and bismuthsubnitrate. The mercury detecting reagents gives a distinctive result that shown by the formation of purple mercury complex in less than 3 minutes.

References

1. Rieger, MM. Harry’s Cosmeticology. 8th Edition. New York: Chemical Publishing Co.,Inc. 2008.h 394.

2. Badan Pengawasan Obat dan Makanan Republik Indonesia. Keputusan Kepala Badan Pengawas Obat dan Makanan Republik Indonesia No. HK.00.01.432.6147. Tanggal 26 November 2008 tentang Kosmetik Mengandung Bahan Berbahaya dan Zat Warna yang Dilarang. Jakarta : Badan Pengawas Obat dan Makanan; 2008. h 1.

3. Sin KW, Tsang HF. Large-scale mercury exposure due to a cream cosmetic : Community-wide case series. Hong Kong Med J 9. 2003. h 329–340.

4. Nurhidayati, L dan Anggada BF,. Spesifisitas dan Sensitivitas Natrium Iodida sebagai Pendeteksi Merkuri dalam Krim Pemutih; PIT & RAKERNAS IAI 2015, Bukittinggi, 7 – 10 Mei 2015

5. Martati, T; Nurhidayati, L, Tiana, 2015, Pembuatan Pereaksi Pendeteksi Merkuri dalam Krim Pemutih Kulit, PIT & RAKERNAS IAI 2015, Bukittinggi, 7 – 10 Mei 2015

6. Lachman L, Liberman HA, Kanig JL. Teori dan praktek farmasi industri. Edisi III. Jakarta: UI Press; 1994. h. 1100-1110, 1118, 1419-23.

7. Abdulaziz, MA, Basavaiah, K, Vinay, KB. Titrimetric and Spectrophotometric Assay of Bupropin Hydrochloride in Pharmaceuticals Using Mercury(II)nitrate. Ecletica quimica, 2010.35 (3)

8. Satiadarma K, Mulja HM, Tjahjono DH, Kartasasmita RE. Asas pengembangan prosedur analisis. Edisi Pertama. Surabaya: Airlangga University Press. 2004. h 47-9.
Published
2018-04-27
How to Cite
NURHIDAYATI, Liliek et al. Specificity of Mercury Detecting Reagents for Skin Lightening Creams. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 16, n. 1, p. 72-77, apr. 2018. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/432>. Date accessed: 26 sep. 2022. doi: https://doi.org/10.35814/jifi.v16i1.432.
Section
Articles