EFFECT OF DRYING TECHNIQUE ON PHYSICAL QUALITY AND ANTI-INFLAMMATORY ACTIVITY OF WILD BETEL LEAVES (Piper sarmentosum Roxb. ex Hunter) EXTRACT

  • Fahleni Fahleni Universitas Pancasila
  • Yuslia Noviani UNIVERSITAS PANCASILA
  • Syarifah Ramadhani UNIVERSITAS PANCASILA
DOI: https://doi.org/10.35814/jifi.v16i1.436

Abstract

Kaduk betel leaves (Piper sarmentosum Roxb. ex. Hunter) contain flavonoids and alkaloids that have anti-inflammatory activity. Processing thick extract into a dry extract is required to determine the appropriate dose and increase the homogeneity. The purpose of tahhis study was to determine the effect of drying method to physical properties of dried powder and its antiinflammatory activity. Thick extract was dried using maltodextrin and lactose as adsorbents with concentrations of extract-adsorbent ratio  1: 1, 1: 2 and 1: 3. Method of drying were freeze drying and adsorbent. The evaluation results based on organoleptic dried powder, water content and flow properties. The water content of dried powder which is dried by freeze drying is smaller than that of  the adsorbent. Organoleptic and flow properties of freeze dried powder results were also better. The best dried powder in each method tested its anti-inflammatory activity using BSA. The test results showed that the anti-inflammatory activity of dried extract of freeze drying (extract-maltodextrin 1:3)  have higher activity with IC50 551.79 ppm compared to dried extract with adsorbent (extract-maltodextrin 1:3) 598.30 ppm.

References

1. Hussain K, Ismail Z, Sadikun A, Ibrahim P. Original Article Bioctive Markers Based Pharmacokinetic Evaluation of Extracts of a Traditional Medicinal Plant, Piper sarmentosum. Evidance-Based Compl Alternative Med. 2009;201(1):1-7.

2. Hussain K, Hashmi FK, Latif A, Ismail Z, Sadikun A. A review of the literature and latest advance in research of Piper sarmentosum. Pharm Biology. 2012;50(8):1045-52.

3. Hossain, M.B., Barry-Ryan, C., Martin-Diana, A.B. & Brunton, N.P. 2010. Effect of drying method on the antioxidant capacity of six Lamiaceae herbs. Food Chemistry 1: 85-91.

4. Indrawati T, Rosliani S. Pembuatan Granul Ekstrak Kerimg Buah Mahkota Dewa dengan Variasi Konsentrasi Adsorben. Jurnal Ilmu Kefarmasian.. 2010.1(1):10-18.

5. Parikh DM. Handbook of Pharmaceutical Granulation Technology. Marcel Dekker Inc. New York: 1995. h.7,156.

6. Parhusip A. Pengeringan Beku dan Pengaruhnya terhadap Produk buah-buahan. Majalah Ilmiah Media Unika. Sumatera Utara: Universitas Katholik Saint Thomas; 1997. h.76-9

7. Rautela S, Badola A, Ritesa. The Lyophilization Process for The Development of Unstable Drug; Indo Am. J. Pharm. Sci, 2015;2(9);1339-41

8. Ridtitid W, Ruangsang P, Reanmongkol W, Wongnawa M. Studies of the anti-inflammatory and antipyretic activities of the methanolic extract of Piper sarmentosum Roxb. leaves in rats. Songklanakarin J Sci Technol 2007; 29(6):1519-26.

9. Rahman SFSA, Sijam K, Omar D. Piper sarmentosum Roxb: A Mini Review of Etnobotany, Phytochemistry and Pharmacology. J Anal Pharmacol Res. 2016;2(5):1-3

10. Soptijah P, Jacoeb AM, Rachmania D. Phytochemistry of the genus Piper. Elsevier Sci. 1997.46(4):597-673.
Published
2018-04-27
How to Cite
FAHLENI, Fahleni; NOVIANI, Yuslia; RAMADHANI, Syarifah. EFFECT OF DRYING TECHNIQUE ON PHYSICAL QUALITY AND ANTI-INFLAMMATORY ACTIVITY OF WILD BETEL LEAVES (Piper sarmentosum Roxb. ex Hunter) EXTRACT. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 16, n. 1, p. 42-44, apr. 2018. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/436>. Date accessed: 31 may 2025. doi: https://doi.org/10.35814/jifi.v16i1.436.
Citation Formats
Issue
Vol 16 No 1 (2018): JIFI
Section
Articles
License

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.