The Role of Fennel Infusion on Estrous Cycle and Follicles Development of White Rats

  • HERA MAHESHWARI BOGOR AGRICULTURAL UNIVERSITY
  • ARYANI SISMIN SATYANINGTIJAS BOGOR AGRICULTURAL UNIVERSITY
  • EVA HARLINA BOGOR AGRICULTURAL UNIVERSITY
  • UMI CAHYANINGSIH BOGOR AGRICULTURAL UNIVERSITY
  • MULYATI EFFENDI BOGOR AGRICULTURAL UNIVERSITY
  • MUHAMMAD ADIB MUSTOFA BOGOR AGRICULTURAL UNIVERSITY
  • YENI KEZIA BEKALANI BOGOR AGRICULTURAL UNIVERSITY

Abstract

This study aims to describe the estrous cycle and follicles development in female rats given infusion of fennel fruit that known to have phytoestrogen compound. Twenty five of female rats were used in this research and were divided into 5 groups. Group I was negative control group (NC), given 1 mL/100g bw of distilled water, group II was positive control group (PC), given 0.0045 mg/100g bw of ethinyl estradiol, groups III, IV and V were treatment groups (TI, T2 and T3), given fennel infusion at 36.5; 73 and 146 mg/100g bw respectively. All treatments were conducted every morning for 20 days by oral route. Changes of vaginal epithelium were observed through vaginal swabs previously stained with Giemsa stain. Histopathological examination of ovarian swere examined to reveal follicles development. Results showed that fennel fruit infusion extended the duration of estrous and metestrous phases, while shortened the proestrous and diestrous phases. Eventhough the longest estrous phase was found in T3 group, there was no significant effect on the lengthening of estrous cycle. Moreover, infusion of fennel fruit had no effect on the development of ovarian follicles, except tended to increase the number of corpus luteum.

Published
2017-09-04
How to Cite
MAHESHWARI, HERA et al. The Role of Fennel Infusion on Estrous Cycle and Follicles Development of White Rats. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 14, n. 1, p. 19-25, sep. 2017. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/44>. Date accessed: 23 nov. 2024.
Citation Formats
Issue
Vol 14 No 1 (2016): JIFI
Section
Articles
License

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.