α-GLUCOSIDASE INHIBITORY ACTIVITY AND FORMULATION OF SOLID LIPID NANOPARTICLE CONTAINING ETHANOL 70% STANDARDIZED EXTRACT OF KUMIS KUCING LEAVES (Orthosiphon stamineus Benth.)

  • Risma Marisi Tambunan UNIVERSITAS PANCASILA
  • Winda Dwi Juliyanti UNIVERSITAS PANCASILA

Abstract

Kumis kucing leaves (Orthosiphon stamineus Benth.) are one type of plants that is able to inhibit the activity of α-glucosidase enzyme. This study aims to formulate Solid Lipid Nanoparticle from ethanol 70% standardized extract of kumis kucing leaves and which give α-glucosidase enzyme inhibitory activity. The result of SLN characteristic for particle size of formula I, II and III shows the result of 51,60 nm; 12.81 nm; 11.87 nm and zeta potential of formula I, II and III show the results -27.67; -10,7; -15.0, respectively. The results of the α-glucosidase enzyme inhibitory activity of the standardized extract, SLN formula I, II and III respectively showed IC50 of 132.9 ppm; 130.3 ppm; 131.4 ppm; 132.2 ppm and Acarbose as comparison showed IC50 of 50.0 ppm. Data processing using t-test statistically at α = 0,05 showed that extract and SLN of formula I had significant difference, thus the best SLN formula was formula I with concentration of tween 80 and propylenglycol of 6% and 10%.

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Published
2018-04-27
How to Cite
TAMBUNAN, Risma Marisi; JULIYANTI, Winda Dwi. α-GLUCOSIDASE INHIBITORY ACTIVITY AND FORMULATION OF SOLID LIPID NANOPARTICLE CONTAINING ETHANOL 70% STANDARDIZED EXTRACT OF KUMIS KUCING LEAVES (Orthosiphon stamineus Benth.). JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 16, n. 1, p. 45-48, apr. 2018. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/485>. Date accessed: 21 nov. 2024. doi: https://doi.org/10.35814/jifi.v16i1.485.
Section
Articles