Antihyperglycemic Combination of Mahogany Seed Oil (Swietenia mahogany(L.) Jacq)-Glibenklamid in Alloxan- Induced Rats

  • DIONYSIUS ANDANG ARIF WIBAWA UNIVERSITAS SETIA BUDI
  • KETUT WIRIANA LARISSA AESTHETIC CENTER SERPONG
  • LUCIA VITA INANDHA DEWI UNIVERSITAS SETIA BUDI
  • RATNA AGUNG SAMSUMAHARTO UNIVERSITAS SETIA BUDI

Abstract

Diabetes mellitus (DM) is a chronic disorder metabolism of glucose in the body. Mahogany seeds (Swietenia mahagoni (L.) Jacq.) reportedly contains fl avonoids, alkaloids and saponins which can be used as therapy of diabetes mellitus. This study aimed to determine the eff ects of antihyperglycemic combination of mahogany seed oil-glibenclamide in male rats hyperglycemiced by alloxan induction. The mahogany seed oil liquefaction processed by using hydrolic pressed instrument 100 psi pressure. This study using Wistar strain male rats aged 2-3 months as many as 35 heads which were divided into 7 groups: group I (normal control) with distilled water added, while the II-VII group with alloxan induced intraperitoneal 140 mg/kg body weight two times. Group II as a negative control was added 0.5% CMC, group III was added glibenclamide 0.09 mg/200 g BB, IV groups oiled mahogany seeds 2 mL/200 g BW, group V, VI, and VII were added a combination of mahogany seed oil glibenclamide with each ratio (75%: 25%, 50%: 50%, 75%: 25%). The distribution of the test preparation 1 times a day for 12 days and blood glucose measurement performed on days 3, 6, 9, and 12. Data has been analyzed by oneway ANOVA (signifi cant p <0.05). The results obtained the combination of mahogany seed oil-glibenclamide provides eff ect to reduction in blood glucose levels induced male rats alloxan, the combination group mahoni-glibenclamide seed oil have equal activity in lowering blood glucose levels with a single chemical drug glibenclamide. Mahogany seed oil is potentially antidiabetic.

References

1. Tjay TH dan Rahardja K. Obat-obat penting: khasiat, penggunaan, dan efek-efek samping. Edisi VI. Jakarta: Elex Media Komputindo. 2007:738, 743, 748-9.

2. Ganong WF. Buku ajar fi siologi kedokteran. Edisi 20. Widjajakusuma D. penerjemah. Jakarta: EGC. Terjemahan dari: Review of medical physiology. 2002:245-6.

3. Sukandar EY, Andrajati R, Sigit Jl, Adnyana IK, Setiadi APP, Kusnandar. ISO farmakoterapi. Jakarta: PT. ISFI Penerbit. 2008:26-36.

4. Ku ma r EK, Ra mes h A, K asiv isw an ath R . Hypoglycemic and antihyperglicemic effect of Gmelina asiatica Lnn. in normal and in alloxan induced diabetic rats. Biological and Pharmaceutical Bulletin. 2005.28(4):729-32.

5. Subhadip H, Archana M, Pinkee P, Jinu J, Pradeep M, Prasad V S. Free radical scavenging and amylase inhibitory activity of swietenia mahagoni seeds oil. International Journal of Pharmacognosy and Phytochemical Research. 2013.5(1):51-6.

6. Hashim M A, Yam M F, Hor S Y, Lim C P, Asmawi M Z, dan Sadikin A. Anti-hyperglycaemic activity of Swietenia macrophylla king (Meliaceae) seed extracts in normoglycaemic rats undergoing glucose tolerance tests. Chinese Medicine. 2013.8(11):1-8.

7. Utama YI. Aktivitas antihiperglikemik kombinasi ekstrak biji mahoni dengan glibenklamid pada mencit jantan galur BALB/C [Skripsi]. Surakarta: Fakultas Farmasi, Universitas Setia Budi; 2014.

8. Damayanti A, dan Bariroh S. Pengolahan biji mahoni (Swietenia macrophylla King) sebagai bahan baku alternatif biodiesel. Jurnal Alam Terbarukan.2012.1(1):8-15.

9. Robinson T. Kandungan organik tumbuhan tingkat tinggi. Kosasih Padwaminta, penerjemah; Bandung: ITB. Terjemahan dari: The Organic Constituent oh Higher Plant. 1995:71-2, 157, 283.

10. Prameswari O M, Widjanarko S B. Uji efek ekstrak air daun pandan wangi terhadap penurunan kadar glukosa darah dan histopatologi tikus diabetes mellitus. Jurnal Pangan dan Agroindustri. 2014.2(20):16-27.

11. Chougale AD, Panaskar SN, Gurao PM, Arvindeka AU. Optimization of alloxan dose is essential to induce stable diabetes for prolong period. Asian Journal of Biochemistry. 2007.2(6):402-8.

12. Herowati R, Widodo G P, Sulistyani W P, dan Hapsari. Efek antidiabetes kombinasi infus biji oyong (Loff a acutangula L,Roxb) dengan metformin dan glibenklamid. Jurnal Farmasi Indonesia. 2013.6(4):211-7.

13. Maiti AS, Dewanjee, and sahu R. Isolation of hypoglycemic phytoconstituent from Swietenia macrophylla Seed. 2009.23(12):1731-3.

14. Mamun-or-Rashid, ANM, Hossain Md,S Hassan N, Dash B K, Sapon Md A, and Sen M K. A review on medicinal plants with antidiabetic activity. Journal of Pharmacognosy and Phytochemistry. 2014.3(4):149- 59.

15. Suharmiati. Pengujian bioaktivitas anti diabetes mellitus tumbuhan obat. Cermin Dunia Kedokteran. 2003.140:8-13.

16. Guyton AC, Hall JE. Buku ajar fi siologi kedokteran. Edisi ke-9. Setiawan Penerjemah; Jakarta: EGC. Terjemahan dari: Texbook of Medical Physiology. 1997:579-88.

17. Sahgal G, Ramanathan S, Sasidharan S, Mordi M N, Ismail S, dan Mansor S M. Brine shrimp letality and oral toxicity studies on Swetenia mahagoni (Linn) jack. seed methanolic extract.Pharmacognosy Research. 2010.2(4):215-20.

18. Goodman and Gilman. Dasar farmakologi terapi. Edisi ke-10. Vol 2. Tim Alih Bahasa Sekolah ITB. Jakarta: EGC. 2007:1670-4.
Published
2017-04-30
How to Cite
WIBAWA, DIONYSIUS ANDANG ARIF et al. Antihyperglycemic Combination of Mahogany Seed Oil (Swietenia mahogany(L.) Jacq)-Glibenklamid in Alloxan- Induced Rats. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 15, n. 1, p. 102-108, apr. 2017. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/492>. Date accessed: 31 may 2023.
Section
Articles