Antiinflammatory Activity Patch Ethanol Extract Of Leaf Katuk (Sauropus Androgynus L. Merr)



The leaf katuk (Sauropus androgynus L. Merr) extract at a dose of 400 mg / kg BW had antiinflammatory activity in rat by induction of carrageenan. Patch are adhesive plasters containing medicinal substances placed on the skin to delivery active substances. Patch can offer practicality, comfort and accuracy of dosage in the application of leaf S. androgynus extract.This research was a laboratory experimental research by making patch of leaf S. androgynus extract and inflammation effect used rats as its animal test. Inflammatory healing activity was seen from the percentage reduction in inflammation in rats after patch application. Patch of leaf S. androgynus extract dose 400 mg / kg BW has percentage of inflammatory inhibition ranged between 66,67-100%. Statistical test results using one-way anova patch leaf S. androgynus extract showed good effectiveness in curing inflammation. Effectiveness between leaf S. androgynus extract patch and diclofenac sodium patch relatively the same in curing inflammation.


1. Selvi V. Senthamarai and Baskar A., Characterization of Anti-Inflammatory Activities and Antinociceptive Effects of Papaverine from Sauropus androgynus (L.) Merr., Global Journal of Pharmacology 6 (3) 2012,: 186-192.

2. Saroni, T. Sadjimin, M. Sja’bani and Zulaela,. Effectiveness of the auropus androgynus (L.) Merr leaf extracts in increasing mother’s breast milk production., Media Litbang Kes., 2004, 14: 20-24.

3. Kustifah, D., Effect of katuk leaves (Sauropus androgynus Merr.) infusion on the milk production of mice. In: Widowati., Medicinal Plant Research from Universities in Indonesia VI. 1st Edition. Jakarta: Ministry of Health Republic of Indonesia, 1991,p: 159

4. Selvi V. Senthamarai and Baskar A., Evaluation of bioactive components and antioxidant activity of Sauropus androgynus plant extracts using GC-MS analysis, International Journal of Pharmaceutical Sciences Review and Research, vol. 12, no. 2, 2012, pp.65–67.

5. S. Singh, D. R. Singh, K. M. Salim, A. Srivastava, L. B. Singh, and R. C. Srivastava., Estimation of proximate composition, micronutrients and phytochemical compounds in traditional vegetables from Andaman and Nicobar Islands. International Journal of Food Sciences and Nutrition, vol. 62, no. 7, 2011, p. 765–773.

6. Bender A. E. and K. S. Ismail., Nutritive value and toxicity of Sauropus androgynous. The Proceedings of the Nutrition Society, vol. 32, no. 2, 1973, p. 79A–80A.

7. Pandit, V., Aisha K., Shyamala B., & Vasiha B., Formulation and Evaluation of Transdermal films for the treatment of Overactive Bladder. International Journal of
PharmaTech Reasearch. Vol. 1, no. 3, 2009, p.799-804

8. Vogel, H. G., Drug Discovery and Evaluation, Springer-Verlag Berlin Heidelberg, Germany, 2002,p. 398.

9. Rowe, R. C., J. S. Paul, and E. Q. Marian, Handbook of Pharmaceutical Excipients, 6th ed., Pharmaceutical Press, London, 2009,525-529

10. Gal, A. dan Nussinovitch, A., Plasticizers in the Manufacture of Novel Skin Bioadhesive Patches, Int. Journal Pharm., 370, 2009, 103-109.

11. Mutalik and Udupa, Glibenclamide Transdermal Patches: Physicochemical, Pharmacodynamic, and Pharmacokinetic Evaluations, J Pharm Sci. 6, 2004, 577-94.

12. Harper, C. A., Handbook of Plastic Technologies, The Complete Guide to Properties and Performance. Mc Graw-Hill Handbooks, NY, USA. 2006

13. Aulton. M.E., Abdul Razzak M.H., and Hogan J.E., The Mechanical Properties of Hydroxypropylmethylcellulose Films Derived from Aqueous System : The Influence of Solid Inclusions. Drug Dev. Ind. Pharm., 7, 1981, 649-668.
How to Cite
DESNITA, Rise; LULIANA, Sri; ANASTASIA, Desy Siska. Antiinflammatory Activity Patch Ethanol Extract Of Leaf Katuk (Sauropus Androgynus L. Merr). JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 16, n. 1, p. 1-5, apr. 2018. ISSN 2614-6495. Available at: <>. Date accessed: 26 sep. 2022. doi: