Pengembangan Formulasi Pasta Antiinflamasi Piroksikam Berbasis Ampas Tahu dalam Pemanfaatan Limbah Tahu Di Purwokerto

  • Nita Triana Sari UNIVERSITAS JENDRAL SOEDIRMAN
  • Putri Dewi Riayah UNIVERSITAS JENDRAL SOEDIRMAN
  • Nabila Fasya UNIVERSITAS JENDRAL SOEDIRMAN
  • Ainul Mardziyati A UNIVERSITAS JENDRAL SOEDIRMAN
  • Namira Fadhilah B UNIVERSITAS JENDRAL SOEDIRMAN
  • Nuryanti Nuryanti UNIVERSITAS JENDRAL SOEDIRMAN
DOI: https://doi.org/10.35814/jifi.v15i2.505

Abstract

The soybean curd residue is the waste product of soybean. It has potential for being excipients in pharmaceutical preparations because of its high carbohydrate element. This study aims to evaluate the soybean curd residue as excipients of piroxicam antiinfl ammatory paste. The excipient of soybean curd residue is made by isolating it with 0.1% KOH, then being characterized by physical, chemical, and functional test after becoming starch. It was prepared in piroxicam antiinfl ammatory paste preparations with ratio of soybean curd residue starch and manihot strach are F1 (0:0.25), F2 (0.25:0), F3 (1.25:1.25), F4 (1.5:1), and F5 (1:1.5). The result of physical and freeze-thaw stability test were analyzed descriptively. The data of viscosity, stickiness, and spreading power test were analyzed using one-way ANOVA. Soybean curd residue starch’s physic is slightly coarse, cubic-shapes powder, uneven surface and nonporous, slightly hygroscopic, and brownish-white. It has distinctive odor and has no taste. Chemical test showed that it contained carbohydrate and had pH 4.9. Functional test showed on average 15% it has viscosity 1959 cps, fl ow time 6.7 seconds and still angle 39.2o. Results of physical and stability tests showed that F3 were the best piroxicam antiinfl ammatory paste formula.

References

1. Kementerian Kesehatan Republik Indonesia. Peraturan Menteri Kesehatan No. 87 Tahun 2013 Tentang Peta Jalan Pengembangan Bahan Baku Obat. Kementerian Kesehatan Republik Indonesia; 2013.

2. Rowe RC, Sheskey PJ, Quinn ME. Handbook of Pharmaceutical Excipients. 6th ed. USA: Pharmaceutical Press and American Pharmacists Association; 2009.

3. Tifani AM, Kumalaningsih S, Mulyadi AF, Pertanian AJTI, Pertanian SPJTI. Produksi bahan pakan ternak dari ampas tahu dengan fermentasi menggunakan EM4 (Kajian pH awal dan lama waktu fermentasi). J Ilm Peternak. 2010;5(1):78–88.

4. Mufrod, Sundari S. Waste of Soya Tofu as Paracetamol Tablet Desintegrant. Pharm J. 1997;1:17.

5. Fressia YM. Pengujian Ampas Tahu Kering Dibandingkan Avicel PH 101 Sebagai Disintegran Tablet Parasetamol yang Dibuat Secara Granulasi Basah. Universitas Surabaya; 2000.

6. Utami DF. Uji Kelayakan Ampas Tahu Kering sebagai Disintegran Tablet Vitamin C yang Dibuat secara Cetak Langsung Dibandingkan dengan Avicel PH 101. Universitas Surabaya; 2000.

7. Agoes G. Sediaan Farmasi Likuida-Semisolida. Bandung: ITB; 2012.

8. Medscape. Piroxicam. 2016 Oktober; Available from: http://reference.medscape.com/drug/feldenepiroxicam- 343300

9. Ansel HC, Allen LVA, Popovich NG. Pharmaceutical Dosage Forms and Drug Delivery System. Philadelphia: Lippincott Williams and Wilkins; 1999.

10. Jufri M, Anwar E, Utami PM. Uji Stabilitas Sediaan Mikroemulsi Menggunakan Hidrolisat Pati (De 35–40) Sebagai Stabilizer. Pharm Sci Res PSR. 2012;3(1).

11. Lachman L, Lieberman HA, Kanig JL. Teori dan Praktek Farmasi Indrustri. 3rd ed. New York: Marcel Dekker, Inc.; 1998. 265-267, 272-273 p. (2).

12. Nayeem N, Md K. Stability studies and evaluation of the semi solid dosage form of the rutin, quercitin, ellagic acid, gallic acid and sitosterol isolated from the leaves of Tectona grandis for wound healing activity. Arch Appl Sci Res. 2011;3(1):43–51.

13. Aswal A, Kalra M, Rout A. Preparation and evaluation of polyherbal cosmetic cream. Pharm Lett. 2013;5(1):83–88.

14. Kemenkes RI. Farmakope Indonesia. 5th ed. Jakarta: Kementerian Kesehatan Republik Indonesia; 2014.

15. Junaedi. Preeparasi dan Karakterisasi Eksipien Koproses Karagenan (Kappa dan lota) dengan Pregelatinasi Pati Singkong Propionat Sebagai Eksipien dalam Sediaan Tablet Mengapung Famotidin. Universitas Indonesia; 2012.

16. Whistler RL, BeMiller JN. Industrial Gum: Polysaccharides and Their Derivates. New York Academic Press; 1993.

17. Lachman L, Lieberman HA, Kanig L. Teori dan Praktek Farmasi Industri. Jakarta: Universitas Indonesia Press; 1994.

18. Tranggono IR, Latifah. Buku Pegangan Ilmu Pengetahuan Kosmetika. Jakarta: PT. Gramedia Pustaka Utama; 2007.

19. Garg A, Aggarwal D, Garg S, Singla AK. Spreading of semisolid formulation. Pharmaceutical Tecnology. 2002;9(2):84–102.

20. Mappa T, Edy HJ, Kojong N. Formulasi Gel Ekstrak Daun Sasaladahan (Peperomia Pellucida (L.) H.B.K) Dan Uji Efektivitasnya Terhadap Luka Bakar Pada Kelinci (Oryctolagus Cuniculus). Pharmacon. 2013;2(2).

21. Astuti lka Y, Hartanti D, Aminiati A. Peningkatan Aktivitas Antijamur Candida Albicans Salep Minyak Atsiri Daun Sirih (Piper Bettle Linn.) Melalui Pembentukan Kompleks Inklusi Dengan B-Siklodekstrin - Enhancing Antifungal Activity Candida. Maj Obat Tradis. 2010;15.

22. Lieberman AH, Rieger MM, Banker SG. Pharmaceutical Dosage Forms: Disperse System. 2nd ed. Vol. 3. New York: Marcel Dekker, Inc; 1998. 265-267, 272-273 p.

23. Voigt R. Buku Pelajaran Teknologi Farmasi. Yogyakarta: UGM Press; 1995.

24. Madjid S, Naser DM, Djavad F. Prevention of crystal growth in Acetaminophen suspension by the use of Polyvinyl pyrrolidone and Bovine serum albumin. International Journal of Pharmacy and Pharmaceutics Sciences. 2003;11(3):139–48.

25. Jusnita J, Syah RA. Formulasi dan Uji Stabilitas Fisik Sediaan Shampo dari Ekstrak Etanol Daun Pare (Momordica charantia Linn.). Indonesia Natural Research Pharmaceutical Journal. 2017;2(1):24–39.
Published
2017-09-30
How to Cite
SARI, Nita Triana et al. Pengembangan Formulasi Pasta Antiinflamasi Piroksikam Berbasis Ampas Tahu dalam Pemanfaatan Limbah Tahu Di Purwokerto. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 15, n. 2, p. 148-154, sep. 2017. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/505>. Date accessed: 22 dec. 2024. doi: https://doi.org/10.35814/jifi.v15i2.505.
Citation Formats
Issue
Vol 15 No 2 (2017): JIFI
Section
Articles

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.