Influence of Vitamin A Supplementation in Medication of Pulmonary TB Patients on Acceleration of Sputum Conversion in Intensive Phase in The Working Area of Medan Kota Sub District Puskesmas

  • Alexander Marpaung FKUMI
  • Parluhutan Siagian UNIVERSITAS SUMATERA UTARA
  • Dina Keumala Sari UNIVERSITAS SUMATERA UTARA

Abstract

Indonesia is the second rank for the most TB (Tuberculosis) cases in the world after India. It’s estimated there are a million cases per year in Indonesia. The objective of the research was to find out the influence of Vitamin A supplementation in the medication of pulmonary TB on the acceleration of sputum conversion time at intensive phase in the Working Area of Puskesmas in Medan Kota Subdistrict. This research applied clinical testing design with experimental approach and Experimental Quasi method. The samples were 30 newly diagnosed pulmonary TB patients consisting of 15 patients in the treatment group and 15 patients in the control group. They were ≥ 18 years old, regularly consumed category I OAT with BMI ≥ 18.5. The statistical data were analyzed by Mann-Whitney statistical testing at reliability rate 95% (p < 0.05). The results of the research on the treatment group discovered that they were mostly 18-27 years old 40.0%, male 73.3%, mostly university students 26.7%, had BTA conversion in the second week 80.0%; and the sputum
conversion time was 2.4 weeks in average. The results of the research on the control group demonstrated that they were mostly 18-27 years old 33.3%, male 80.0%, mostly university students and entrepreneurs 20.0%, had BTA conversion in the second week 80%; and the sputum conversion time was 4.1 weeks in average. Vitamin A supplementation in the medication of pulmonary TB patients had some influence on the acceleration of sputum conversion at intensive phase (p = <0.001) < (alpha = 0.05). Vitamin A supplementation in the medication of pulmonary TB patients had some influence on the acceleration of sputum conversion at intensive phase in the Working Area of Puskesmas in Medan Kota Subdistrict. speed up wound healing on second degree burns. White egg gel had significantly difference compared to negative control of NaCl 0.9% and no signifi cantly difference compared to Bioplacenton as positive control.

References

1. Ahmad, I., Kushwaha, R., Kant, S., Natu, SM., Singh, SK., Usman, K., Ali, W., Katiar, DK., Saleem, M., 2012. Role Of Vitamin A and Zink Supplementation on sputum conversion time in pulmonary Tuberculosis patients. JRAAS. Erstwhile King George’s Medical University

2. Dinas Kesehatan Kota Medan, 2015. Laporan Kasus TB Paru 2013-2015.

3. Karyadi E, West Ce, Schultink W, Nelwan Rh, Gross R, Amin Z, Dolmans WM, Schlebusch H, Vander Meer JW. 2002. A Double-Blind, Placebo-Controlled Study Of Vitamin A and Zinc Supplementation In Persons With Tuberculosis In Indonesia: Effects On Clinical Response And Nutritional Status, Am J Clin Nutr.

4. Kemenkes RI, 2012. Direktorat Jenderal Bina Upaya Kesehatan, Direktorat Jenderal Pengendalian Penyakit dan Penyehatan Lingkungan. Standart Prosedur Operasional Pemeriksaan Mikroskopis TB. Jakarta.

5. Kemenkes RI, 2013. Riset Kesehatan Dasar (Riskesdas). Badan Penelitian dan Pengembangan Kesehatan. Jakarta.

6. Kemenkes RI, 2014. Pedoman Nasional Penanggulangan Tuberkulosis. Jakarta.

7. Kemenkes RI, 2015. Pusat data dan Informasi. Tuberkulosis, Temukan, Obati sampai sembuh. Jakarta.
Nagpal, M., Devgun, P., Chawla, N., 2014. A Study On Nutritional Status And Change In Body Mass Index With Treatment Outcome In Smear-Positive Pulmonary TB Patients on Dots in Amritsar City. India.

8. Pakasi, Trevino A., Elvina, Karyadi., Yulianti W., Yogy Simanjuntak., Ni Made D.S., Michael S., Nining D., Jos WM van der Meer., Koos van der Velden.,&Wil MV Dolmans. 2009. Vitamin A deficiency and other factors associated with severe tuberculosis in Timor and Rote Islands, East Nusa Tenggara Province, Indonesia chapter 3 PDF hosted at the Radboud Repository of the Radboud University Nijmegen.

9. Pakasi, Trevino A, Elvina Karyadi, Ni Made Desy Suratih, Michael Salean, Nining Darmawidjaja , Hans Bor, Koos van der Velden, Wil MV Dolmans, Jos WM van der Meer, 2010. Zinc and Vitamin A supplementation fails to reduce sputum conversion time in severely malnourished pulmonary tuberculosis patients in Indonesia.

10. Tsani, R. M., Kasno, 2011. Gambaran Klinis Tuberkulosis Paru di RSUP Dr. Kariadi Semarang Periode Januari-Juni 2011. Semarang.

11. WHO, 2013. Guideline: Nutritional Care and Support for Patients with Tuberculosis. Geneva.

12. WHO, 2015. Global Tuberculosis Report 2015. Geneva, Switzerland.
Published
2018-10-30
How to Cite
MARPAUNG, Alexander; SIAGIAN, Parluhutan; SARI, Dina Keumala. Influence of Vitamin A Supplementation in Medication of Pulmonary TB Patients on Acceleration of Sputum Conversion in Intensive Phase in The Working Area of Medan Kota Sub District Puskesmas. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 16, n. 2, p. 124-130, oct. 2018. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/512>. Date accessed: 15 dec. 2019. doi: https://doi.org/10.35814/jifi.v16i2.512.
Section
Articles