Effect of Egg White Gel againts Burn Healing on White Rat (Rattus novergicus)

  • Lucia Hendriati Universitas Katolik Widya Mandala Surabaya
  • Iwan Sahrial Hamid UNIVERSITAS AIRLANGGA
  • Teguh Widodo UNIVERSITAS KATOLIK WIDYA MANDALA
  • Chintya Wandasari UNIVERSITAS KATOLIK WIDYA MANDALA
  • Putu Mirah Risata UNIVERSITAS KATOLIK WIDYA MANDALA
DOI: https://doi.org/10.35814/jifi.v16i2.532

Abstract

Egg whites traditionally used for the treatment of burns. In this research, egg white was formulated as gel dosage form for easy to use and covered unpleasant odor. The aim of the study was to determined effectivity of egg white in gel dosage form against the healing of superficial partial thickness burns (second degree) on white rats (Rattus novergicus) Wistar strain with parameters were macrophages, fibroblasts, collagen deposit density and wound healing. Research subject were  male white rats aged 3 months. Second degree burns on the back of rat with a diameter of 2 cm were made by  using a hot coin with temperature 80 ° C for 20 seconds. 18 white rats divided into 3 groups of treatment that is negative control using 0.9% NaCl, positive control using Bioplacenton®, and 40% egg white gel as treatment. Based on the experimental results, white egg gel  given topically decreased the number of macrophages and increase the number of fibroblasts, increase the density of collagen deposits and speed up wound healing on second degree burns. White egg gel had significantly difference with negative control of NaCl 0.9% and no significantly difference  with Bioplasenton as positive control.

References

1. Noer MS. Penanganan luka bakar akut. In Noer, M.S. (eds) Penanganan luka bakar. 2006. Airlangga University Press. 3-5.

2. Abdou AM, Kim M, Sato K. Functional Proteins and Peptides of Hen’s Egg Origin. In Ledesma BH, Hsieh CC (eds). Bioactive Food Peptides in Health and Disease. 2013. InTech. 120-136.

3. Kratz F. Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles. J. Control. Release. 2008. 132:171–183.

4. Pieroni A, Quave CL, and Santoro RF. Folk pharmaceutical knowledge in the territory of the dolomiti lucane, Inland Southern Italy. Journal of Ethnopharmacology. 2004. 95: 373–384.

5. Rukiana A. Uji efek penyembuhan luka bakar menggunakan putih telur ayam kampung (albumin) pada kelinci (Oryctolagus cuniculus). Skripsi. Fakultas Farmasi. Universitas Indonesia Timur, Makassar. 2011.

6. James HH, David MH. Burns, in : Schwartz’s principles of surgery. 18th ed. McGraw-Hill. New York. 2005. p.189-216

7. Townsend CM, Beauchamp RD, Evers BM, and Mattox KL. (eds). Ilmu Bedah sabiton, Buku Kedokteran EGC. 2010.

8. Gurtner GC. Wound Healing, Normal and Abnormal. In: Thorne CH, Beasly RW, Aston SJ, Bartlett SP, Gurtner GC, Spear SL. Grabb and Smith’s Plastic. 6th ed. 2007. 15-22.

9. Huseini HF, Rahimzadeh G, Fazeli MR, Mehrazma M, Salehi M. Evaluation of wound healing activities of kefir products. Burns. 2012. 38. 719 – 723.

10. Garg A, Deepika A, Garg S, Singla AK. Spreading of Semisolid Formulation. USA: Pharmaceutical Tecnology. 2002. 84-104.

11. Bushe L. Presented at the Advisory Committee for Pharmceutical Science Meeting on March 12. 2003. Diakses pada 30 Agustus 2016, www.fda.gov/ohrms/dockets/ac/03/slides/3926SI_11Buhse.ppt

12. Falanga V. The chronic wound: impaired healing and solutions in the context of wound bed preparation. Blood Cells, Molecules, and Diseases. 2004.32 (1): 88–94.

13. Saeed MA, Ahmad I, Yaqub U, Akbar S, Waheed A, Saleem M, Nasirudin. Aloe vera: a plant of vital significance. Quarterly ScienceVision. 2003. Vol.9 No.1-2 Jul-Dec.

14. Biswas TK, Auddy B, Bhattacharya NP, Bhattacharya S. Mukherjee B. Wound healing activity of human placental extracts in rats. Acta Pharmacol Sin. 2001.22:1113-6.

15. Arisanty IP. Konsep Dasar Manajemen Perawatan Luka. 2013. EGC.
Published
2018-10-30
How to Cite
HENDRIATI, Lucia et al. Effect of Egg White Gel againts Burn Healing on White Rat (Rattus novergicus). JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 16, n. 2, p. 231-237, oct. 2018. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/532>. Date accessed: 25 apr. 2024. doi: https://doi.org/10.35814/jifi.v16i2.532.
Citation Formats
Issue
Vol 16 No 2 (2018): JIFI
Section
Articles

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.