Effect of Spirulina Platensis on Level Analysis, Histopathology, Insulin and Glut-4 Expression in Wistar Rats Induced by Streptozotosin

  • Kintoko Kintoko Universitas Ahmad Dahlan
  • Rifqi Ferry Balfas Universitas Muhadi Setaibudi
  • Nura Ustrina Universitas Ahmad Dahlan
  • Sitarina Widyarini Universitas Gadjah Mada
  • Lintang Cahya Saputri Universitas Ahmad Dahlan
  • Anandita Nurwijayanti Universitas Ahmad Dahlan
  • Fajar Slamet Riana Universitas Ahmad Dahlan
  • Neni Tri Anggraini Universitas Ahmad Dahlan
DOI: https://doi.org/10.35814/jifi.v16i2.541

Abstract

Based on Basic Health Research, in Yogyakarta the incidence of diabetes mellitus based on doctor's diagnosis is 2.6% and symptoms will increase with age, but will decrease from age> 65 years. In the treatment of diabetes mellitus there are several treatments with synthetic drugs and natural ingredients for natural ingredients such as Spirulina platensis. Spirulina platensis is one of the microalgae that contains the natural spectrum of carotene and xantophyll pigment mixtures, and with fikocyanin has antioxidant activity, and Spirulina platensis can show a decrease in blood sugar.


The type of research conducted is an experimental study. Spirulina platensis is made with several doses of 36 mg, 72 mg, and 144 mg. Rats were divided into 6 groups, 5 groups of streptozotosin induced at a dose of 45 mg / kgBW until the mice had DM were characterized by high KGD yield, then given spirulina suspension, measured in sugar levels on days 0-28. After that the mice in the blood and then analyzed the effect of Spirulina platensis on creatinine and urea in blood. The results were analyzed using SPSS ANOVA and Post Hoc Test methods with 95% confidence level.


The results of the analysis of levels in various groups showed that in the induction of streptozotocin treated with spirulina plantesis various doses there was improvement in each analysis of the levels obtained, and also at the dose STZ+SP 36 in each analysis can improve the level of analysis. While on histopathology result and insulin expression in pancreas and histology and expression of glucose transporter 4 and histopathology on kidney and liver showed good change at various treatment dose group especially in STZ+SP 36 group. So at STZ+SP 36 dose showing the change both in this study.

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Published
2018-10-30
How to Cite
KINTOKO, Kintoko et al. Effect of Spirulina Platensis on Level Analysis, Histopathology, Insulin and Glut-4 Expression in Wistar Rats Induced by Streptozotosin. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 16, n. 2, p. 238-247, oct. 2018. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/541>. Date accessed: 16 oct. 2025. doi: https://doi.org/10.35814/jifi.v16i2.541.
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Vol 16 No 2 (2018): JIFI
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