Isolation of Black Garlic Polyphenol Compounds and Toxicity Tests on Shrimp Larvae (Artemia salina Leach)

  • Santi Nur Handayani Universitas Jenderal Soedirman
  • Lidya Cahyo Bawono Universitas Jenderal Soedirman
  • Diana Pramesti Ayu Universitas Jenderal Soedirman
  • Hesti Nurrizqi Pratiwi Universitas Jenderal Soedirman


Cancer is one of diseases caused by cell division that is uncontrollable. Cervical cancer is a cancer that suffered by many women. Alternative medicine of cancer disease is use black garlic. Black garlic is the result of processing the garlic with high temperature and humidity without addition of other substances. In that process occur Maillard reaction that cause changes in the color, smell, and taste of the original on the garlic. Such reaction also lead to an increase some bioactive compounds such as S-allyl cysteine ​​(SAC), amino acids, flavonoids, and polyphenols. To determine the toxic properties of black garlic extract, it is necessary to do isolation of polyphenolic compounds and toxicity test against Artemia salina Leach. When calculated by SPSS application, the obtained LC50values of black garlic extract on the aging prosess time variations of 30 days and 40 days showed concentration of 682.433 and 572.403 ppm.


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How to Cite
HANDAYANI, Santi Nur et al. Isolation of Black Garlic Polyphenol Compounds and Toxicity Tests on Shrimp Larvae (Artemia salina Leach). JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 16, n. 2, p. 145-149, oct. 2018. ISSN 2614-6495. Available at: <>. Date accessed: 17 sep. 2019. doi: