Analysis of Traditional Medicine Formula for Hemorrhoid In Java Island; Ethnopharmacology Study RISTOJA
Abstract
The using of traditional medicine among community has being accepted and become huge potency to be developed by our country. One of disease which is often treated with traditional medicine is hemorrhoid or in bahasa as known as “wasir”. According to the result of ethopharmacology research of traditional medicine and jamu (RISTOJA) 2015 in java island, there are several formulas used by traditional healers to treat hemorrhoid. In order to fi nd potential formulas to be developed, a descriptive study was conducted involving identifi cation of medicinal plant and also literature study about its benefi t and toxicity evidences. The plants which named in formula’s ingredient were analized to see how important and utility value for hemorrhoid treatment. Literature study was conducted to assess potential benefi t and toxicity. The result said there were 37 species of medicinal plant in 25 family used in traditional medicine formula for hemorrhoid. Based on Frequency Citation(FC), Utility Value (UC) and literature study, Graptophyllum pictum (L.) Griff ., Curcuma longa L., Aloe vera (L.) Burm.F, and Musa balbisiana have enough scientifi c evidence to be studied further development.
References
1. Desak MM, Madihah, Joko K, Fitri K, Johan I. Biosaintifika. Biosaintifika. 2017;9(2):345–56.
2. Siswanto. Saintifikasi jamu sebagai upaya terobosan untuk mendapatkan bukti ilmiah tentang manfaat dan keamanan jamu. Natl Inst Heal Res Dev Minist Heal Repub Indones [Internet]. 2012;15:203–11. Available from: http://ejournal.litbang.depkes.go.id/index.php/hsr/article/view/2994
3. Purwaningsih EH. Jamu , Obat Tradisional Asli Indonesia : Pasang Surut Pemanfaatannya di Indonesia (Jamu, Indonesian Traditional Medicine: The Ups and Downs). eJKI. 2013;1(2):85–9.
4. Nurrani L, Tabba S, Mokodompit HS. Kearifan Lokal Dalam Pemanfaatan Tumbuhan Obat Oleh Masyarakat Di Sekitar Taman Nasional Aketajawe Lolobata, Provinsi Maluku Utara. J Penelit Sos dan Ekon Kehutan. 2015;12(3):163–75.
5. Astana PRW, Ardiyanto D, Triyono A, Mana TA. Uji Keamanan dan Manfaat Ramuan Jamu untuk Hemoroid Dibandingkan dengan Diosmin Hisperidin. Media Penelit dan Pengemb Kesehat. 2017;27(1):57–64.
6. Lohsiriwat V. Hemorrhoids: From basic pathophysiology to clinical management. World J Gastroenterol. 2012;18(17):2009–17.
7. Abramowitz L, Godeberge P, Staumont G SD. Clinical practice guidelines for the treatment of hemorrhoid disease. Gastroenterol Clin Biol. 2001;25(6–7)::674-702.
8. Riss S, Weiser FA, Schwameis K, Riss T, Mittlböck M, Steiner G, et al. The prevalence of hemorrhoids in adults. Int J Colorectal Dis. 2012;27(2):215–20.
9. Neilwan A. Views and Attitudes of Association Executives in Indonesia for Medical Use of Traditional / Complementary Health Services. J Med Planta [Internet]. 2011;1(4):82–8. Available from:
http://majour.maranatha.edu/index.php/jmp/article/view/861
10. Sholikhah EN. Indonesian medicinal plants as sources of secondary metabolites for pharmaceutical industry. J Med Sci [Internet]. 2016;48(4):226–39. Available from: https://www.researchgate.net/profile/Eti_Sholikhah2/publication/312271498_Indonesian_medicinal_plants_as_sources_of_secondary_metabolites_
for_pharmaceutical_industry/links/5919ca45aca2722d7cfe6834/Indonesian-medicinal-plants-as-sources-of-secondary-metabo
11. Hoffman B, Gallaher T. Importance indices in ethnobotany. Ethnobot Res Appl. 2007;5:201–18.
12. Jaradat NA, Zaid AN, Al-Ramahi R, Alqub MA, Hussein F, Hamdan Z, et al. Ethnopharmacological survey of medicinal plants practiced by traditional healers and herbalists for treatment of some urological diseases in the West Bank/Palestine. BMC Complement Altern Med. 2017;17(1).
13. Bolson M, Hefler SR, Dall’Oglio Chaves EI, Gasparotto Junior A, Cardozo Junior EL. Ethno-medicinal study of plants used for treatment of human ailments, with residents of the surrounding region of forest fragments of Paraná, Brazil. J Ethnopharmacol. 2015;161:1–10.
14. Neamsuvan O, Tuwaemaengae T, Bensulong F, Asae A, Mosamae K. A survey of folk remedies for gastrointestinal tract diseases from Thailand’s three southern border provinces. J Ethnopharmacol [Internet]. 2012;144(1):11–21. Available from: http://dx.doi.org/10.1016/j.jep.2012.07.043
15. Sudarsono DF. Diagnosis dan penanganan hemoroid. 4:31–4.
16. Balinado LO CM. An Ethnomedicinal Study of Plants and Traditional Health Care Practices in District 7 , Cavite , Philippines. Int Conf Chem Agric Biol Med Sci. 2017;
17. Widiyastuti Y, Adi MBS, Widayat T. PONOROGO JAWA TIMUR Medicinal Plants Species in Sigogor Nature Reserve Ponorogo , East Jawa. 2017;10(2):78–87.
18. Habibah S. Etnobotani tumbuhan obat oleh masyarakat Kecamatan Sreseh Kabupaten Sampangan Madura. Universitas Islam Negeri Maulana Malik Ibrahim; 2014.
19. Singh P, Khosa RL, Mishra G JK. Pharmacognostical evaluation of aerial parts of Graptophyllum pictum (L.) Griff. (Syn: Justicia picta Linn.): A well-known folklore medicinal plant. Anc Sci Life. 2015;34(4):223–9.
20. Jiangseubchatveera N, Liawruangrath S, Teerawutgulrag A, Santiarworn D, Pyne SG, Liawruangrath B. Phytochemical Screening , Phenolic and Flavonoid Contents , Antioxidant and Cytotoxic Activities of Graptophyllum pictum (L.) Griff. Chiang Mai J Sci. 2017;44(1):193–202.
21. Christophe W. Medicinal Plants Of The Asia-pacific: Drugs For The Future? Singapore: World Scientific Publishing Co., Ltd.; 2006.
22. Sya’haya S, Iyos RN. Pengaruh Pemberian Ekstrak Daun Ungu (Graptophylum Pictum Griff) terhadap Penyembuhan Hemoroid. Majority. 2016;5(5):155–60.
23. Ozaki Y, Sekita S, Soedigdo S, Harada M. Antiinflammatory effect of Graptophyllum pictum (L.) Griff. Chem Pharm Bull (Tokyo) [Internet]. 1989;37(10):2799–802. Available from: http://www.ncbi.nlm.nih.gov/pubmed
/2611941
24. Ogbonnia SO, Coker H a B, Ukpo GE. Blood glucose lowering effect of aqueous extract of Graptophyllum pictum ( Linn ) Griff . on alloxan-induced diabetic rats and its acute toxicity in mice. African J Biotechnol. 2011;10(6):1039–43.
25. Naher S, Ferdous B, Datta T, Faria Rashid U, Nahian Tasnim T, Akter S, et al. Ayurvedic influences in folk medicine: A case study of a folk medicinal practitioner of Jhalokathi in Barisal district, Bangladesh. Am J Sustain Agric. 2013;7(4):333–43.
26. Mulyani H, Widyastuti S, Ekowati V. “Tumbuhan Herbal sebagai Jamu Pengobatan Tradisional Terhadap Penyakit Dalam Serat Primbon Jampi Jawi Jilid I.” J Penelit Hum. 2016;21(2):73–91.
27. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009;14(2):141–53.
28. Araújo CC, Leon LL. Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz [Internet]. 2001;96(5):723–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11500779
29. Balitbangkes. Vademekum Tanaman Obat. Jakarta: Badan Litbangkes. Kemenkes RI; 2010.
30. Coats, B. C., & Ahola R. Aloe vera the silent healer. A Modern Study of Aloe vera. Dallas: Bill C Coats; 1979.
31. Jayakrishna, C., Karthik, C., Barathi, S., Kamalanathan, D. and Indra ArulSelvi P. In vitro propagation of Aloe barbadensis Miller, a miracle herb. Res Plant Biol. 2011;1(5):22–6.
32. Gantait S, Sinniah UR, Das PK. Aloe vera: A review update on advancement of in vitro culture. Acta Agric Scand Sect B Soil Plant Sci. 2014;64(1):1–12.
33. Agarry OO, Olaleye MT, Bello-Michael CO. Comparative antimicrobial activities of aloe vera gel and leaf. Afr J Biotechnol. 2005;4(12):1413–4.
34. Radha MH, Laxmipriya NP. Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review. J Tradit Complement Med. 2015;5(1):21–6.
35. Orendu Attah M, Watson Jacks T, Jacob A, Eduitem O, John B. The Effect of Aloe vera (Linn) On Cutaneous Wound Healing and Wound Contraction Rate in Adult Rabbits. Nov J Med Biol Sci [Internet]. 2016;5(3):1–8. Available from: http://nova-jmbs.com/index.php/jmbs/article/view/104
36. Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract. 1999;49(447):823–8.
37. Sharma R, Sharma HK. Ethnomedicines of Sonapur, Kamrup district, Assam. Indian J Tradit Knowl. 2010;9(1):163–5.
38. Kodoh J, Mojiol AR. Traditional knowledge on the uses of medicinal plants among the ethnic communities in
kudat, sabah, malaysia. 2017;5:79–85.
39. Prahlad A, Memorial DA. ASSESSMENT OF ANTI-ULCER POTENTIAL OF UNRIPE FRUIT EXTRACT OF MUSA BALBISIANA IN STRESS INDUCED ULCER. 2018;7(8):1328–36.
40. Tin HS, Padam BS, Vairappan CS, Abdullah MI, Chye FY. Effect of preparation and extraction parameters of banana (Musa balbisiana cv. Saba) inflorescence on their antibacterial activities. Sains Malaysiana. 2015;44(9):1301–7.
41. Mathew NS, Negi PS. Traditional uses, phytochemistry and pharmacology of wild banana (Musa acuminata Colla): A review. J Ethnopharmacol [Internet]. 2017;196:124–40. Available from: http://dx.doi.org/10.1016/j.jep.2016.12.009
42. Kalita H, Boruah DC, Deori M, Hazarika A, Sarma R, Kumari S, et al. Antidiabetic and antilipidemic effect of Musa balbisiana root extract: A potent agent for glucose homeostasis in streptozotocin-induced diabetic rat. Front Pharmacol. 2016;7(MAY):1–11.
43. Vij T, Prashar Y. A review on medicinal properties of Carica papaya Linn. Asian Pacific J Trop Dis [Internet]. 2015;5(1):1–6. Available from: http://dx.doi.org/10.1016/S2222-1808(14)60617-4
44. Halim SZ, Abdullah NR, Afzan A, Rashid BAA, Jantan I, Ismail Z. Acute toxicity study of Carica papaya leaf extract in Sprague Dawley rats. J Med Plants Res [Internet]. 2011;5(xx):1867–72. Available from: http://www.academicjournals.org/JMPR
45. Laksmitawati DR, Widyastuti A, Karami N, Afifah E, Rihibiha DD, Nufus H, et al. Anti-inflammatory effects of Anredera cordifolia and piper crocatum extracts on lipopolysaccharide-stimulated macrophage cell line. Bangladesh J Pharmacol. 2017;12(1):35–40.
46. Fitriyani A, Winarti L, Muslichah S, Nuri N. Uji Antiinflamsi Ekstrak Metanol Daun Sirih Merah ( Piper crocatum Ruiz & Pav) Pada Tikus Putih. Maj Obat Tradis. 2011;16(1):34–42.
47. Agung SRI, Kusuma F, Tjitraresmi AMI, Susanti G. Antibacterial Effect of Red Piper Betle Leaf Ethanolic Extracts to Lactobacillus Acidophilus and Lactobacillus Bifidus Growth Inhibition. Asian J Pharm Clin Res [Internet]. 2017;(Iii):65–8. Available from: https://innovareacademics.in/journals/index.php/ajpcr/article/viewFile
/19490/11507
48. Anugrahwati M, Purwaningsih T, Rustina, Manggalarini JA, Alnavis NB, Wulandari DN, et al. Extraction of Ethanolic Extract of Red Betel Leaves and Its Cytotoxicity Test on HeLa Cells. Procedia Eng [Internet]. 2016;148:1402–7. Available from: http://dx.doi.org/10.1016/j.proeng.2016.06.569
49. SAFITHRI M, YASNI S, BINTANG M, RANTI AS. Toxicity Study of Antidiabetics Functional Drink of Piper crocatum and Cinnamomum burmannii. HAYATI J Biosci [Internet]. 2012;19(1):31–6. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1978301916301292
50. Rachmawaty FJ, Nugraha ZS, Fidianingsih I, Amalina M, Widira D. P9 The effect of ethanolic extract of red betel vine leaves ( Piper crocatum ) to the livers and kidneys of DDY mice in acute and subchronic toxicity study. Biochem Pharmacol [Internet]. 2017;139:127. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0006295217303337
51. Effect of red Piper betle leaf ( Piper crocatum Ruiz & Pav .) ethanolic extract on plasma biochemical and hematological parameters in vivo. 2017;11(11):9–12.
52. Agung S, Kusuma F, Sumiwi SA, A MRD. Study of Red Piper Betle Leaf ( Piper crocatum Ruiz & Pav .) Ethanolic
Extract Effect on Gastric Mucosa. Int J Sci Eng Appl Sci –. 2017;3(12):6–10.
53. Tan JBL, Lim YY, Lee SM. Antioxidant and antibacterial activity of Rhoeo spathacea (Swartz) Stearn leaves. J Food Sci Technol. 2015;52(4):2394–400.
54. Pérez G. RM. Anti-inflammatory activity of Ambrosia artemisiaefolia and Rhoeo spathacea. Phytomedicine. 1996;3(2):163–7.
55. Rosales-Reyes T, de la Garza M, Arias-Castro C, Rodríguez-Mendiola M, Fattel-Fazenda S, Arce-Popoca E, et al. Aqueous crude extract of Rhoeo discolor, a Mexican medicinal plant, decreases the formation of liver preneoplastic foci in rats. J Ethnopharmacol. 2007;115(3):381–6.
2. Siswanto. Saintifikasi jamu sebagai upaya terobosan untuk mendapatkan bukti ilmiah tentang manfaat dan keamanan jamu. Natl Inst Heal Res Dev Minist Heal Repub Indones [Internet]. 2012;15:203–11. Available from: http://ejournal.litbang.depkes.go.id/index.php/hsr/article/view/2994
3. Purwaningsih EH. Jamu , Obat Tradisional Asli Indonesia : Pasang Surut Pemanfaatannya di Indonesia (Jamu, Indonesian Traditional Medicine: The Ups and Downs). eJKI. 2013;1(2):85–9.
4. Nurrani L, Tabba S, Mokodompit HS. Kearifan Lokal Dalam Pemanfaatan Tumbuhan Obat Oleh Masyarakat Di Sekitar Taman Nasional Aketajawe Lolobata, Provinsi Maluku Utara. J Penelit Sos dan Ekon Kehutan. 2015;12(3):163–75.
5. Astana PRW, Ardiyanto D, Triyono A, Mana TA. Uji Keamanan dan Manfaat Ramuan Jamu untuk Hemoroid Dibandingkan dengan Diosmin Hisperidin. Media Penelit dan Pengemb Kesehat. 2017;27(1):57–64.
6. Lohsiriwat V. Hemorrhoids: From basic pathophysiology to clinical management. World J Gastroenterol. 2012;18(17):2009–17.
7. Abramowitz L, Godeberge P, Staumont G SD. Clinical practice guidelines for the treatment of hemorrhoid disease. Gastroenterol Clin Biol. 2001;25(6–7)::674-702.
8. Riss S, Weiser FA, Schwameis K, Riss T, Mittlböck M, Steiner G, et al. The prevalence of hemorrhoids in adults. Int J Colorectal Dis. 2012;27(2):215–20.
9. Neilwan A. Views and Attitudes of Association Executives in Indonesia for Medical Use of Traditional / Complementary Health Services. J Med Planta [Internet]. 2011;1(4):82–8. Available from:
http://majour.maranatha.edu/index.php/jmp/article/view/861
10. Sholikhah EN. Indonesian medicinal plants as sources of secondary metabolites for pharmaceutical industry. J Med Sci [Internet]. 2016;48(4):226–39. Available from: https://www.researchgate.net/profile/Eti_Sholikhah2/publication/312271498_Indonesian_medicinal_plants_as_sources_of_secondary_metabolites_
for_pharmaceutical_industry/links/5919ca45aca2722d7cfe6834/Indonesian-medicinal-plants-as-sources-of-secondary-metabo
11. Hoffman B, Gallaher T. Importance indices in ethnobotany. Ethnobot Res Appl. 2007;5:201–18.
12. Jaradat NA, Zaid AN, Al-Ramahi R, Alqub MA, Hussein F, Hamdan Z, et al. Ethnopharmacological survey of medicinal plants practiced by traditional healers and herbalists for treatment of some urological diseases in the West Bank/Palestine. BMC Complement Altern Med. 2017;17(1).
13. Bolson M, Hefler SR, Dall’Oglio Chaves EI, Gasparotto Junior A, Cardozo Junior EL. Ethno-medicinal study of plants used for treatment of human ailments, with residents of the surrounding region of forest fragments of Paraná, Brazil. J Ethnopharmacol. 2015;161:1–10.
14. Neamsuvan O, Tuwaemaengae T, Bensulong F, Asae A, Mosamae K. A survey of folk remedies for gastrointestinal tract diseases from Thailand’s three southern border provinces. J Ethnopharmacol [Internet]. 2012;144(1):11–21. Available from: http://dx.doi.org/10.1016/j.jep.2012.07.043
15. Sudarsono DF. Diagnosis dan penanganan hemoroid. 4:31–4.
16. Balinado LO CM. An Ethnomedicinal Study of Plants and Traditional Health Care Practices in District 7 , Cavite , Philippines. Int Conf Chem Agric Biol Med Sci. 2017;
17. Widiyastuti Y, Adi MBS, Widayat T. PONOROGO JAWA TIMUR Medicinal Plants Species in Sigogor Nature Reserve Ponorogo , East Jawa. 2017;10(2):78–87.
18. Habibah S. Etnobotani tumbuhan obat oleh masyarakat Kecamatan Sreseh Kabupaten Sampangan Madura. Universitas Islam Negeri Maulana Malik Ibrahim; 2014.
19. Singh P, Khosa RL, Mishra G JK. Pharmacognostical evaluation of aerial parts of Graptophyllum pictum (L.) Griff. (Syn: Justicia picta Linn.): A well-known folklore medicinal plant. Anc Sci Life. 2015;34(4):223–9.
20. Jiangseubchatveera N, Liawruangrath S, Teerawutgulrag A, Santiarworn D, Pyne SG, Liawruangrath B. Phytochemical Screening , Phenolic and Flavonoid Contents , Antioxidant and Cytotoxic Activities of Graptophyllum pictum (L.) Griff. Chiang Mai J Sci. 2017;44(1):193–202.
21. Christophe W. Medicinal Plants Of The Asia-pacific: Drugs For The Future? Singapore: World Scientific Publishing Co., Ltd.; 2006.
22. Sya’haya S, Iyos RN. Pengaruh Pemberian Ekstrak Daun Ungu (Graptophylum Pictum Griff) terhadap Penyembuhan Hemoroid. Majority. 2016;5(5):155–60.
23. Ozaki Y, Sekita S, Soedigdo S, Harada M. Antiinflammatory effect of Graptophyllum pictum (L.) Griff. Chem Pharm Bull (Tokyo) [Internet]. 1989;37(10):2799–802. Available from: http://www.ncbi.nlm.nih.gov/pubmed
/2611941
24. Ogbonnia SO, Coker H a B, Ukpo GE. Blood glucose lowering effect of aqueous extract of Graptophyllum pictum ( Linn ) Griff . on alloxan-induced diabetic rats and its acute toxicity in mice. African J Biotechnol. 2011;10(6):1039–43.
25. Naher S, Ferdous B, Datta T, Faria Rashid U, Nahian Tasnim T, Akter S, et al. Ayurvedic influences in folk medicine: A case study of a folk medicinal practitioner of Jhalokathi in Barisal district, Bangladesh. Am J Sustain Agric. 2013;7(4):333–43.
26. Mulyani H, Widyastuti S, Ekowati V. “Tumbuhan Herbal sebagai Jamu Pengobatan Tradisional Terhadap Penyakit Dalam Serat Primbon Jampi Jawi Jilid I.” J Penelit Hum. 2016;21(2):73–91.
27. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009;14(2):141–53.
28. Araújo CC, Leon LL. Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz [Internet]. 2001;96(5):723–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11500779
29. Balitbangkes. Vademekum Tanaman Obat. Jakarta: Badan Litbangkes. Kemenkes RI; 2010.
30. Coats, B. C., & Ahola R. Aloe vera the silent healer. A Modern Study of Aloe vera. Dallas: Bill C Coats; 1979.
31. Jayakrishna, C., Karthik, C., Barathi, S., Kamalanathan, D. and Indra ArulSelvi P. In vitro propagation of Aloe barbadensis Miller, a miracle herb. Res Plant Biol. 2011;1(5):22–6.
32. Gantait S, Sinniah UR, Das PK. Aloe vera: A review update on advancement of in vitro culture. Acta Agric Scand Sect B Soil Plant Sci. 2014;64(1):1–12.
33. Agarry OO, Olaleye MT, Bello-Michael CO. Comparative antimicrobial activities of aloe vera gel and leaf. Afr J Biotechnol. 2005;4(12):1413–4.
34. Radha MH, Laxmipriya NP. Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review. J Tradit Complement Med. 2015;5(1):21–6.
35. Orendu Attah M, Watson Jacks T, Jacob A, Eduitem O, John B. The Effect of Aloe vera (Linn) On Cutaneous Wound Healing and Wound Contraction Rate in Adult Rabbits. Nov J Med Biol Sci [Internet]. 2016;5(3):1–8. Available from: http://nova-jmbs.com/index.php/jmbs/article/view/104
36. Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract. 1999;49(447):823–8.
37. Sharma R, Sharma HK. Ethnomedicines of Sonapur, Kamrup district, Assam. Indian J Tradit Knowl. 2010;9(1):163–5.
38. Kodoh J, Mojiol AR. Traditional knowledge on the uses of medicinal plants among the ethnic communities in
kudat, sabah, malaysia. 2017;5:79–85.
39. Prahlad A, Memorial DA. ASSESSMENT OF ANTI-ULCER POTENTIAL OF UNRIPE FRUIT EXTRACT OF MUSA BALBISIANA IN STRESS INDUCED ULCER. 2018;7(8):1328–36.
40. Tin HS, Padam BS, Vairappan CS, Abdullah MI, Chye FY. Effect of preparation and extraction parameters of banana (Musa balbisiana cv. Saba) inflorescence on their antibacterial activities. Sains Malaysiana. 2015;44(9):1301–7.
41. Mathew NS, Negi PS. Traditional uses, phytochemistry and pharmacology of wild banana (Musa acuminata Colla): A review. J Ethnopharmacol [Internet]. 2017;196:124–40. Available from: http://dx.doi.org/10.1016/j.jep.2016.12.009
42. Kalita H, Boruah DC, Deori M, Hazarika A, Sarma R, Kumari S, et al. Antidiabetic and antilipidemic effect of Musa balbisiana root extract: A potent agent for glucose homeostasis in streptozotocin-induced diabetic rat. Front Pharmacol. 2016;7(MAY):1–11.
43. Vij T, Prashar Y. A review on medicinal properties of Carica papaya Linn. Asian Pacific J Trop Dis [Internet]. 2015;5(1):1–6. Available from: http://dx.doi.org/10.1016/S2222-1808(14)60617-4
44. Halim SZ, Abdullah NR, Afzan A, Rashid BAA, Jantan I, Ismail Z. Acute toxicity study of Carica papaya leaf extract in Sprague Dawley rats. J Med Plants Res [Internet]. 2011;5(xx):1867–72. Available from: http://www.academicjournals.org/JMPR
45. Laksmitawati DR, Widyastuti A, Karami N, Afifah E, Rihibiha DD, Nufus H, et al. Anti-inflammatory effects of Anredera cordifolia and piper crocatum extracts on lipopolysaccharide-stimulated macrophage cell line. Bangladesh J Pharmacol. 2017;12(1):35–40.
46. Fitriyani A, Winarti L, Muslichah S, Nuri N. Uji Antiinflamsi Ekstrak Metanol Daun Sirih Merah ( Piper crocatum Ruiz & Pav) Pada Tikus Putih. Maj Obat Tradis. 2011;16(1):34–42.
47. Agung SRI, Kusuma F, Tjitraresmi AMI, Susanti G. Antibacterial Effect of Red Piper Betle Leaf Ethanolic Extracts to Lactobacillus Acidophilus and Lactobacillus Bifidus Growth Inhibition. Asian J Pharm Clin Res [Internet]. 2017;(Iii):65–8. Available from: https://innovareacademics.in/journals/index.php/ajpcr/article/viewFile
/19490/11507
48. Anugrahwati M, Purwaningsih T, Rustina, Manggalarini JA, Alnavis NB, Wulandari DN, et al. Extraction of Ethanolic Extract of Red Betel Leaves and Its Cytotoxicity Test on HeLa Cells. Procedia Eng [Internet]. 2016;148:1402–7. Available from: http://dx.doi.org/10.1016/j.proeng.2016.06.569
49. SAFITHRI M, YASNI S, BINTANG M, RANTI AS. Toxicity Study of Antidiabetics Functional Drink of Piper crocatum and Cinnamomum burmannii. HAYATI J Biosci [Internet]. 2012;19(1):31–6. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1978301916301292
50. Rachmawaty FJ, Nugraha ZS, Fidianingsih I, Amalina M, Widira D. P9 The effect of ethanolic extract of red betel vine leaves ( Piper crocatum ) to the livers and kidneys of DDY mice in acute and subchronic toxicity study. Biochem Pharmacol [Internet]. 2017;139:127. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0006295217303337
51. Effect of red Piper betle leaf ( Piper crocatum Ruiz & Pav .) ethanolic extract on plasma biochemical and hematological parameters in vivo. 2017;11(11):9–12.
52. Agung S, Kusuma F, Sumiwi SA, A MRD. Study of Red Piper Betle Leaf ( Piper crocatum Ruiz & Pav .) Ethanolic
Extract Effect on Gastric Mucosa. Int J Sci Eng Appl Sci –. 2017;3(12):6–10.
53. Tan JBL, Lim YY, Lee SM. Antioxidant and antibacterial activity of Rhoeo spathacea (Swartz) Stearn leaves. J Food Sci Technol. 2015;52(4):2394–400.
54. Pérez G. RM. Anti-inflammatory activity of Ambrosia artemisiaefolia and Rhoeo spathacea. Phytomedicine. 1996;3(2):163–7.
55. Rosales-Reyes T, de la Garza M, Arias-Castro C, Rodríguez-Mendiola M, Fattel-Fazenda S, Arce-Popoca E, et al. Aqueous crude extract of Rhoeo discolor, a Mexican medicinal plant, decreases the formation of liver preneoplastic foci in rats. J Ethnopharmacol. 2007;115(3):381–6.
Published
2018-10-30
How to Cite
ASTANA, Peristiwan R Widhi; NISA, Ulfatun.
Analysis of Traditional Medicine Formula for Hemorrhoid In Java Island; Ethnopharmacology Study RISTOJA.
JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 16, n. 2, p. 115-123, oct. 2018.
ISSN 2614-6495.
Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/562>. Date accessed: 22 dec. 2024.
doi: https://doi.org/10.35814/jifi.v16i2.562.
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