Efek Antiplasmodium dari Ekstrak Etilasetat Kulit Batang Asam Kandis (Garcinia parvifolia) secara In Vitro
Abstract
This research was carried out to assess the antiplasmodic activity of six fractions from the aethylacetate extract of the stem barks of Garcinia parfivolia. The result showed that fractions C, D, and G were IC50 < 10 µg/ml, fraction E: IC50 24,19 µg/ml, and fraction F and H: > 100 µg/ml against a chloroquine resistant strain of P. falciparum FCR-3.
References
1. Pribadi W. Masalah penyakit malaria dan upaya penanggulangannya menjelang tahun 2000. Pidato Pengukuhan Guru Besar Tetap FKUI, Jakarta,1999.
2. Mustofa. Molekul antimalaria alami: Potensi dan tantangan pengembangannya sebagai obat baru malaria. Majalah Obat Tradisional. 2003. 8(26):8-9.
3. Elufioye TO and Aqbedahunsi JM. Antimalarial activities of Tithonia diversifolia (Asteraceae) and Crossopteryx febrifuga (Rubiaceae) on mice in vivo. Journal of Ethnopharmacology. 2004. 93:167.
4. Xu JY, Lai YH, Imiyabir Z, and Goh SH. Xanthones from Garcinia parvifolia. J. Nat. Prod. 2001. 64: 1191-5.
5. Syamsudin. Kemotaksonomi dan farmakologi tumbuhan keluarga Guttiferae. Jurnal Ilmu Kefarmasian. 2006. 3(2):16-9.
6. Syamsudin, Shirly K, and Broto S. Screening for antiplasmodial, antioxidant, cytotoxic and antibacterial activities from Garcinia parvifolia Miq. Asian J of Plant Sciences (to be published). 2007b.
7. Syamsudin, Soesanto T, Subagus W, Darmono and Mustofa. In vitro and in vivo antiplasmodial activities of Stem barks extracts of Garcinia parvifolia Miq. Int. J. of Trop. Medicine. 2007a. 2(2):41-4.
8. Harborne JB. Phytochemical methods. London: Chapman and Hall; 1973.
9. Trager W. The cultivation of Plasmodium falciparum: application in basic applied research on malaria. Annals of Trop Med and Parasitology. 1976.81:511-29.
10. Finney DJ. Probit analysis; A statistical treatment of the sigmoid response curve. Cambridge; 1964.
11. Direktorat Pengawasan Obat dan Makanan. Analisis obat tradisional Jilid I. Jakarta: Departemen Kesehatan; 1987.
12. Preres V, Nagem TJ. Trioxygenated naturally occuring xanthones. Phytochemistry. 1997. 44(2):191-214.
13. Likhitwitayawuid K, Phadungcharoen T, Krunkai J. Antimalaria xanthones from Garcinia cowa. Planta Medica. 1998. 64:70-2.
14. Fotie J, Bohle S, Leimanis M, Georgias E, Rukunga G, Nkengfack A. Lupeol long-chain fatty acid esters with antimalarial activity from Hollarhena floribunda. J. of Nat Prod. 2006. 69:62-7.
15. Riekmann KH. Visual in vitro test for determining the drug sensitivity of Plasmodium falciparum. The Lancet June. 1982. 12:1333-5
16. Gessler MC, Nkunya MHN, Mwasumbi LB, Heinrich M, Toner M. Screening Tanzanian medicinal plants for antimalarial activity. Acta. Trop. 1994. 55:65-7.
2. Mustofa. Molekul antimalaria alami: Potensi dan tantangan pengembangannya sebagai obat baru malaria. Majalah Obat Tradisional. 2003. 8(26):8-9.
3. Elufioye TO and Aqbedahunsi JM. Antimalarial activities of Tithonia diversifolia (Asteraceae) and Crossopteryx febrifuga (Rubiaceae) on mice in vivo. Journal of Ethnopharmacology. 2004. 93:167.
4. Xu JY, Lai YH, Imiyabir Z, and Goh SH. Xanthones from Garcinia parvifolia. J. Nat. Prod. 2001. 64: 1191-5.
5. Syamsudin. Kemotaksonomi dan farmakologi tumbuhan keluarga Guttiferae. Jurnal Ilmu Kefarmasian. 2006. 3(2):16-9.
6. Syamsudin, Shirly K, and Broto S. Screening for antiplasmodial, antioxidant, cytotoxic and antibacterial activities from Garcinia parvifolia Miq. Asian J of Plant Sciences (to be published). 2007b.
7. Syamsudin, Soesanto T, Subagus W, Darmono and Mustofa. In vitro and in vivo antiplasmodial activities of Stem barks extracts of Garcinia parvifolia Miq. Int. J. of Trop. Medicine. 2007a. 2(2):41-4.
8. Harborne JB. Phytochemical methods. London: Chapman and Hall; 1973.
9. Trager W. The cultivation of Plasmodium falciparum: application in basic applied research on malaria. Annals of Trop Med and Parasitology. 1976.81:511-29.
10. Finney DJ. Probit analysis; A statistical treatment of the sigmoid response curve. Cambridge; 1964.
11. Direktorat Pengawasan Obat dan Makanan. Analisis obat tradisional Jilid I. Jakarta: Departemen Kesehatan; 1987.
12. Preres V, Nagem TJ. Trioxygenated naturally occuring xanthones. Phytochemistry. 1997. 44(2):191-214.
13. Likhitwitayawuid K, Phadungcharoen T, Krunkai J. Antimalaria xanthones from Garcinia cowa. Planta Medica. 1998. 64:70-2.
14. Fotie J, Bohle S, Leimanis M, Georgias E, Rukunga G, Nkengfack A. Lupeol long-chain fatty acid esters with antimalarial activity from Hollarhena floribunda. J. of Nat Prod. 2006. 69:62-7.
15. Riekmann KH. Visual in vitro test for determining the drug sensitivity of Plasmodium falciparum. The Lancet June. 1982. 12:1333-5
16. Gessler MC, Nkunya MHN, Mwasumbi LB, Heinrich M, Toner M. Screening Tanzanian medicinal plants for antimalarial activity. Acta. Trop. 1994. 55:65-7.
Published
2007-09-30
How to Cite
SYAMSUDIN, Syamsudin; PRASETYO, Budi; ANTONIUS, Antonius.
Efek Antiplasmodium dari Ekstrak Etilasetat Kulit Batang Asam Kandis (Garcinia parvifolia) secara In Vitro.
JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 5, n. 2, p. 49-52, sep. 2007.
ISSN 2614-6495.
Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/573>. Date accessed: 05 nov. 2024.
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