Seleksi Mikroba Endofit Curcuma Zedoria dalam Memproduksi Senyawa Kimia Antimikroba

  • Yoice Srikandace Pusat Penelitian Bioteknologi-LIPI
  • Yatri Hapsari Pusat Penelitian Bioteknologi-LIPI
  • Partomuan Simanjuntak Pusat Penelitian Bioteknologi-LIPI


It is well known, that temu putih (Curcuma zedoaria Berg.), a rhizome of the Zingiberaceae, is oftenly used as medicine. In this connection, the potential secondary metabolites as anticancer and antimicrobes are produced by endophytic microbes in the plant. In this research, five endophytic microbes from the Curcuma zedoaria’s rhizome were fermented to produce compounds as antimicrobes.


1. Prana MS. Temu Lawak (Curcuma xanthorrhiza Roxb.). Buletin Kebun Raya Indonesia, Botanical
Gardens of Indonesia. 1978. 3(6):191.

2. Matsuda, Hisashi, Morikawa T, Ninomiya K, and Yoshikawa M. 2001. Absolute stereostructure of carabrane-type sesquiterpene and vasorelaxant-active sesquiterpenes from zedoariae rhizome. Tetrahedron. 2001. 57:8433–53.

3. Petrini OTN, Siebeer LT, Viret O. Ecology, metabolite production and substrate utilization and endophytic
fungi. Natural Toxin. 1992.p.185-96.

4. Strobel GA, Hess WM, Fund E, Sidhu RS, and Yang X. Taxol from fungal endophytes and the issue of biodiversity. J Industrial Microbiol. 1996a. 17:417-29.

5. Strobel GA, Yang X, Sears J, Kramer P, Sidhu RS, and Hess WM. Taxol from pestatiopsis microspore, an endophytic fungus of Taxus wallachiana. Microbiology. 1996b. 142:435–40.

6. Stierle A, Strobel G, Stierle D, Grothans P, and Bigunami G. The research for taxol-producing microorganism among the endophytic fungi of the Pacific yew, Taxus brevifolia. J of nat Prod. 1995a. 58(9):1315-24.

7. Shibuya H, Agusta A, Ohashi K, Maehara S, and Simanjuntak P. Biooxidation of (+)-catechin and (-)-epicatechin into 3,4-dihydroxy flavan derivatives by the endophytic fungus Diaporthe sp. isolated from a tea plant. Chem Pharm Bull. 2005. 53(7):866-7.
How to Cite
SRIKANDACE, Yoice; HAPSARI, Yatri; SIMANJUNTAK, Partomuan. Seleksi Mikroba Endofit Curcuma Zedoria dalam Memproduksi Senyawa Kimia Antimikroba. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 5, n. 2, p. 77-84, sep. 2007. ISSN 2614-6495. Available at: <>. Date accessed: 10 june 2023.