Karakterisasi Rekristalit Antalgin-Fenilbutason dengan Pelarut Aseton sebagai Suatu Sistem Interaksi Fisika

  • Ilma Nugrahani Sekolah Farmasi Institut Teknologi Bandung
  • Slamet Ibrahim Sekolah Farmasi Institut Teknologi Bandung
  • Sundani Nurono Soewandhi Sekolah Farmasi Institut Teknologi Bandung
  • Sukmadjaja Asyarie Sekolah Farmasi Institut Teknologi Bandung

Abstract

Recrystallization with acetone of antalgyne, phenylbutazone, and the mixture of binary system has been characterized. The aim of this research was looking for thermodynamic and x-ray diffraction characteristic of re-crystallite to compare with raw material characteristics. The result used to confirm validity of cool contact methods to identify physical interaction of antalgine-phenylbutazone that has been developed in the preliminary research. Recrystallites characterized by DSC and powder-XRD shows the polymorphism cases, but the co-recrystallite of binary system show the peritecticum physical interaction, similar with the physical interaction of the raw material binary system before recrystallization. Principally, the results of this investigation prove that cool contact methods by acetone could be used for identify physical interaction of antalgine-phenylbutazone.

References

1. Cartensen JT. Solid pharmaceutics: mechanical properties and rate phenomena. New York: Academic Press; 1980. p. 102-108.

2. Davis RE et al. Studies phase relationships in cocrystal systems, american crystallographic association, ACA transaction. 2004; 39: 41-61.

3. Giordano F dan Rossi A. Phase diagrams in the binary system. Boll Chim Farm. 2000; 139(4): 345-9.

4. Nugrahani I, Asyarie S, Soewandhi SN. Metode kontak dingin untuk mendeteksi interaksi fisika pseudoefedrin hidroklorida-parasetamol dan antalgin, fenilbutason (I). Artocarpus Media Pharmaceutica Indonesiana. 2006; (6).

5. Nugrahani I, Murat AS, Asyarie S, Soewandhi SN, Ibrahim S. Konfirmasi metode kontak dingin dengan DSC dan XRD untuk penentuan jenis interaksi fisika pseudoefedrin hidroklorida-parasetamol dan antalgin-fenilbutason(II), Artocarpus Media Pharmaceutica Indonesiana. 2006; (7).

6. Soewandhi SN, Moegihardjo, Pamuji JS, danMauludin R. Profil disolusi campuran peritektik mixed crystal ibuprofen dan asetaminofen, Acta Pharmaceutica Indonesia, 2005; 30: 65-71.
How to Cite
NUGRAHANI, Ilma et al. Karakterisasi Rekristalit Antalgin-Fenilbutason dengan Pelarut Aseton sebagai Suatu Sistem Interaksi Fisika. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 5, n. 1, p. 37-44, apr. 2007. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/586>. Date accessed: 04 june 2023.
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Vol 5 No 1 (2007): JIFI
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Articles

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.