Beberapa Kelainan Genetik yang Bersifat Protektif terhadap Infeksi Malaria

  • Syamsudin Syamsudin Universitas Pancasila

Abstract

Resistance to malarial infection is dependent on the development of an immune response by the host and to a varying extend, a certain innate characteristics possessing protective value against infection. Innate resistance is not always absolute and genetically determined factors, but instead can act to reduce the severity of infection and improve survive. Mechanism of action resistance to malarial infection will be discussed in this article.

References

1. Wiser WF. Malaria. diambil dari http://www. tulane.edu/~wiser/protozoology/notes/ malaria.html.
diakses 12 April, 2003.

2. WHO. The situation of malaria in the world. J Epid Week. 1994; 72: 269-92.

3. Ntoumi F, Rogler C, Dieye A. Imbalanced distribution of Plasmodium falciparum MSP-1 genotypes related to sickle cell trait. Molecular Medicine. 1997; 3(9): 581-92.

4. Kaplan J, Burns J, Vaidya A, Webster, Weidanz W. Malaria In: Immunology and moleculer biology of parasitic infections. 3thEd. Editor: Warren K. Blackwell Scientific Publication. 1989.p.302-33.

5. Bruce-Chwatt Jl. In: Essential Malariology. Pathology and immunology of human malaria. William Heinemann Medical Books Ltd, 1980. p.53-63.

6. Wirth DF. Drug resistance and transfection in Plasmodium In: Molecular approaches to parasitology. Editor: Boothroyd JC, Komuniecki R. New York: John Wiley & Sons Inc; 1995. p.227- 41.

7. Mayes PA, Rodwell VW, Granner DK, Murray RK. Biokimia. Harper Ed. 20. Jakarta EGC; 1987.

8. Martin TW, Weissman IM, Zeballos RJ, Stephenson SR. Exercise and hypoxia increase sickling in venous blood from an exercising limb in individuals with sickle cell trait. Am J Med. 1989; 87: 48-56.

9. Luzzato GA, Nwachuku-Jarett ES, Reddy S. Increased sickling of parasitized erythrocytes as mechanism of resistance against malaria in the sickle cell trait. Lancet. 1970; 1(7642): 319 - 21.

10. Shinar E, Shalev 0, Rachmilewitz EA, Schier SL. Erytrocyte membrane skeleton abnormalities in severe B-thalassemia. Blood. 1987; 70(1): 158-169.

11. Grinberg LN, Rachmilewitz EA, Kitrossky N, Chevion M. Hydroxyl radicalgeneration in ß-Thalassemic red blood cells. Free Radic Biol Med. 1995; 18: 611-15.

12. Luzzi GA, Merry AH, Newbold C1, Marsh K, Pasvol G, Weatherall DJ. Surface antigen expression on Plasmodium falciparum-infected erythrocytes is modified in alpha and beta-Thalassemia. J Exp Med. 1991; 173: 785-91.
How to Cite
SYAMSUDIN, Syamsudin. Beberapa Kelainan Genetik yang Bersifat Protektif terhadap Infeksi Malaria. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 5, n. 1, p. 45-48, apr. 2007. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/587>. Date accessed: 27 dec. 2024.
Citation Formats
Issue
Vol 5 No 1 (2007): JIFI
Section
Articles

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.