Ekstraksi Kurkuminoid dari Temulawak (Curcuma xanthorriza Roxb.) secara Perkolasi dengan Pelarut Etanol

  • Imam Paryanto Pusat Teknologi Farmasi dan Medika BPPT
  • Bambang Srijanto Pusat Teknologi Farmasi dan Medika BPPT

Abstract

A study has been carried out to find out the effect of temperature, solvent flow rate and ethanol-water solvent composition on curcuminoid content in the extract produced from the extraction process (percolation) of Curcuma xanthorriza Roxb. Experiment was designed and analysed using complete random analysis with 3 factors and 2 duplications. Observed variables were: (1) varied extraction temperatures of 35°C, 45° C and 55° C; (2) varied solvent flow rates of 40 ml/minute, 60 ml/minute and 80 ml/minute; and (3) various solvent (ethanol 96%-water) compositions of 100:0,75:25 and 50:50, respectively. The measurement of curcuminoid content in the extract was done using spectrophotometer UV-visible light with wavelength setting of 420 nm. The results of analysis statistically explained that temperature and solvent flowrate did not affect significantly on curcuminoid content in the extract, but ethanol-water (solvent) composition did significantly influence on extracted curcuminoid content each shown in F table 0.01. Therefore, the optimum result of the study showed that the higher the ethanol concentration in the solvent was, the higher the curcuminoid content in the extract became. The highest curcuminoid content of 10.7% in extract was resulted at temperature of 35° C, solvent flow rate of 40 ml/minute and ethanol: water (solvent) composition of 100:0.

References

1. Liang OB, Widjaja Y & Puspa S. Beberapa aspek isolasi, identifikasi dan penggunaan komponenkomponen Curcuma xanthorriza Roxb. dan Curcuma domestika Val. Prosiding Simposium Nasional Temulawak, Bandung, 1985, Lembaga Penelitian Universitas Padjajaran.
2. Sidik, Moelyono MW & Muhtadi A. Temulawak (Curcuma xanthorriza Roxb.) Indonesia. Yayasan Pengembangan Bahan Alam. 1993.

3. Arora R. Antiinflammatory studies on Curcuma longa (turmeric). Indian J Med Res. 1971;59:1289-95.

4. Srivasta R. Antithrombotic effect curcumin. Thrombosis Res. 1985;40:413–417.

5. Deodhar SD. Prelimenary study on anthirheumatic activity of curcumin (diferuloylmethane). Indian J Med Res. 1980;71:632-634.

6. Sathoskar RR. Evaluation of antiinflamatory property of curcumin (diferuloylmethane) in patients with prospective inflamation. Int J Clin Pharamacol Ther Toxicol. 1986;24(12):651-654.

7. Bourne KZ, Bourne N, Reising SF, Stanberry LR. Plant products as topical microbicide candidates: assessment of in vitro and in vivo activity against herpes simplex virus type 2. Antiviral Res. 1999;42:219-26.

8. Kawamori T, Lubet R, Steele VE. Chemopreventative effect of curcumin, a naturally occurring antiinflammatory agent, during the promotion/ progression stages of colon cancer. Cancer Res. 1999;59:597-601.

9. Rao S. Effects of curcumin on serum and liver cholesterol in rats. J Nutrition. 1985;100:1307-1316.

10. Kiso Y. Antihepatotoxic principles of Curcuma longa rizhomes. Planta Medica. 1983;49:185–187.

11. Suyatna FD. The effects of curcuma againts paracetamol induced liver damage in rats. Med J of
the University of Indonesia. 1992;1(1):20-34.

12. Rismunandar. Rempah-rempah komoditi ekspor indonesia. Bandung: Sinar Baru; 1988.

13. Suwiah A. Pengaruh perlakuan bahan dan jenis pelarut yang digunakan pada pembuatan temulawak instan (Curcuma xanthorriza Roxb.) terhadap rendemen dan mutunya [skripsi). Bogor: FATETA IPB; 1991.

14. Sirait M. Pemeriksaan kadar xanthorrizol dalam Curcuma xanthorriza. Simposium Nasional
Temulawak. UNPAD, Bandung, 1985:2.

15. List PH & Schmidt PC. Phytopharmaceutical technology. London: Heyden & Son Limited; 1989.

16. Ria EB. Pengaruh jumlah pelarut, lama ekstraksi dan ukuran bahan terhadap rendemen dan mutu oleoresin temulawak (skripsi). Bogor: FATETA IPB; 1989.

17. Bambang S. Perbandingan ekstraksi kurkumin dari temulawak (Curcuma xanthorriza Roxb.) dengan pelarut aseton dan etanol. Prosiding Seminar Nasional, Fakultas Farmasi, Universitas
Muhammadiyah Purwokerto, Purwokerto, 2005.

18. AOAC. Official methods of analysis of the association of official analytical chemist. Virginia USA: AOAC Incorporation; 1984.

19. WHO. Quality control methods for medicinal plant material. Geneva: WHO; 1998.

20. ASEAN. Standard of asean herbal medicine. Jakarta: Aksara Buana Printing; 1993.p.201.
How to Cite
PARYANTO, Imam; SRIJANTO, Bambang. Ekstraksi Kurkuminoid dari Temulawak (Curcuma xanthorriza Roxb.) secara Perkolasi dengan Pelarut Etanol. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 4, n. 2, p. 74-77, sep. 2006. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/592>. Date accessed: 03 july 2024.
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