Pengaruh Pembentukan Dispersi Padat Meloksikam - PVP K-25 terhadap Penetrasi Perkutan dari Sediaan Gel
Most drugs are weak acids or bases and have a low water solubility. Ionized molecules are generally in small amounts absorbed by biological membranes. One possibility of drug modification for transport through biological membranes is by solid disperse system which enhances drug solubility. The solubility of drugs in such a system increases due to particle size reduction and transformation of its crystalline form. In this study, the dispersion system was used to increase the solubility of meloxicam which can influence the percutaneous permeation. Solid dispersion was prepared by modified solvent method using various ratios of PVP K-25 and was also able to lower the meloxicam melting point. Solid dispersion of meloxicam-PVP-K-25 (1:5) was characterized by infrared absorption spectroscopy, differential scanning calorimetry, X-ray diffraction analysis, and thin layer chromatography. Percutaneous penetration was studied by using a flow-through diffusion cell system, and besides that showed a lower diffusion rate of solid dispersion of meloxicam-PVP-K-25 compared to meloxicam.
2. Abdou H.Dissolution, bioavailability and bioequivalence. Easton: Mack Publ and Co; 1989.p.56-57.
3. Lee SJ. Hydrophobization of ionic drugs for transport through membrane, in advance in drug delivery system. In: Anderson JM, editor. New York: Elseiver Science Publisher BV; 1987.p.3 - 12.
4. Cheong A. Enhanced percutaneous absorption of piroxicam via salt formation with ethanolamines, Pharm Res. 2002;19(9):1375–1379.
5. Chiou WL dan Riegelman L. Pharmaceutical application of solid dispersion system, J Pharm Sci, 1971; 60:1281 - 1302.
6. Brithish Pharmacopoeia Commision. Brithish Pharmacopoeia. London: Her Majesty's Office; 2002.p.1110-1111.
7. American Society of Hospital Pharmacist. American hospital formulary drugs information. Bethesda: American Society of Hospital Pharmacist Inc; 2002.p.2008-2009.
8. Katzung BG.. Basic and clinical pharmacology. 8th ed. New York: The Mc Graw-Hill Co Inc; 2001.p.606.
9. Plaizier JA and Neve RE. Interaction of povidone with aromatic compound III: thermodynamic of binding equilibria and interaction force in buffer solution at varying pH value and varying dielectric constant. J Pharm Sci.1982;76(10):552-555.
10. Gupta SK, Bansal P, Bhardwarj RK, Jaiswal J and Velpandian T. Comparison of analgesic and antiinflamatory activity of meloxicam gel with diclofenac and piroxicam gels in animal models: pharmacokinetic parameters after topical application.
11. Lafuente MP, Franch J, Durall I, Diaz-Bertrana MC and Marquez RM. Comparison between meloxicam and transdermally administered fentanyl for treatment of postoperative pain in dogs undergoing osteotomy of the tibia and fibula and placement of uniplanar external distraction device. 2006;227(11):1768 - 74.
12. Miranda HF, Puig MM, Prieto JC, Pinardi G.
Synergism between paracetamol and nonsteroidal antiinflamatory drugs in experimental acute pain. 2006;121 (1-2):22-8.
13. Sasutjarit AR, Sirivat A, Vayumhasuwan P. Viscoelastic properties of carbopol 940 gels and their relationships to piroxicam diffusion coefficients in gel bases. 2005;22(12):2134-40.
Copyright @2017. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted non-commercial used, distribution and reproduction in any medium
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.