Stres Oksidatif di dalam Model Kerja Obat Antimalaria

  • Syamsudin Syamsudin Universitas Pancasila

Abstract

Several antimalarial drugs may act by producing free radicals, anion superoxide through a redox cycling process with oxygen. The mode of action of chloroquine, primaquine, artemisinin, anthraquinone and xanthones as antimalarial drug is partly increasing the oxidative stress in the parasitized red blood cell.

References

1. Halliwel B, Gutteridge JMC. Free radicals in biology and medicine. 3 rd ed. Oxford: Oxford University Press. 1998.p.22-24.

2. Aldunate J, Morello A. Free radicals in the mode of action of antiparasitic drug. In: Okezie A, editor. Free radicals in tropical disease. Switzerland: Hardwood Academic Publishers; 1993.p.137-43.

3. Proctor P, Reynold E. Free radicals and disease in man, physiological chemistry and physics and medical NMR. 1984.p.16,175-95.

4. Kiaran K. Membrane transport in the malaria-infected erytrocyte. Physiological Reviews. 2001;81(2):495-537.

5. Postma MS. Oxidative stress in malaria: implications for prevention and therapy. Pharm World Sci.
1996;18:121.

6. Aldoro S, Uhunmwangho S, Adekoya A, Faronhi O. Rat liver microsomal lipid peroxidation is increased by antimalarial drugs in the presence of oxidant. Pharmacol toxicol. 2004;1-6.

7. Fitch CD. Chloroquine resistance in malaria a deficiency of chloroquine binding. Proc Natl Acad
Sci. 1986;64.

8. Augusto 0, Alvez M, Colli W, Filardi LS and Brenez. Primaquine can mediate hydroxyl radical generation by Trypanosoma cruzi extracts. Biochemical and Biophysical Research Communications. 1986;135. 1029-34.

9. Meshnick SR. The mode of action of antimalarial endoperoxides. Transactions of the royal society
of tropical medicine and hygiene. 1998;88(1):31-32.

10. Hiroyuki M, Kinoshita M, Fukuyama. Antioxidant xanthones from Garcinia subelliptica.
Phytochemistry. 1994;36(2):501.

11. Likhitwitayawuid K, Phadungcharo, Krunkrai J. Antimalarial xanthones from Garcinia dulcis. Planta
Medica. 1998;64:281-82.

12. Winter R, Ignatuschechenco M, Olumide. Potentiation of an antimalarial oxidant drug. antimicrobial agents and chemotherapy. 1997;47(7): 1449-54.
How to Cite
SYAMSUDIN, Syamsudin. Stres Oksidatif di dalam Model Kerja Obat Antimalaria. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 4, n. 1, p. 48-50, apr. 2006. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/605>. Date accessed: 05 nov. 2024.
Citation Formats
Issue
Vol 4 No 1 (2006): JIFI
Section
Articles

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.