Stres Oksidatif di dalam Model Kerja Obat Antimalaria
Abstract
Several antimalarial drugs may act by producing free radicals, anion superoxide through a redox cycling process with oxygen. The mode of action of chloroquine, primaquine, artemisinin, anthraquinone and xanthones as antimalarial drug is partly increasing the oxidative stress in the parasitized red blood cell.
References
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2. Aldunate J, Morello A. Free radicals in the mode of action of antiparasitic drug. In: Okezie A, editor. Free radicals in tropical disease. Switzerland: Hardwood Academic Publishers; 1993.p.137-43.
3. Proctor P, Reynold E. Free radicals and disease in man, physiological chemistry and physics and medical NMR. 1984.p.16,175-95.
4. Kiaran K. Membrane transport in the malaria-infected erytrocyte. Physiological Reviews. 2001;81(2):495-537.
5. Postma MS. Oxidative stress in malaria: implications for prevention and therapy. Pharm World Sci.
1996;18:121.
6. Aldoro S, Uhunmwangho S, Adekoya A, Faronhi O. Rat liver microsomal lipid peroxidation is increased by antimalarial drugs in the presence of oxidant. Pharmacol toxicol. 2004;1-6.
7. Fitch CD. Chloroquine resistance in malaria a deficiency of chloroquine binding. Proc Natl Acad
Sci. 1986;64.
8. Augusto 0, Alvez M, Colli W, Filardi LS and Brenez. Primaquine can mediate hydroxyl radical generation by Trypanosoma cruzi extracts. Biochemical and Biophysical Research Communications. 1986;135. 1029-34.
9. Meshnick SR. The mode of action of antimalarial endoperoxides. Transactions of the royal society
of tropical medicine and hygiene. 1998;88(1):31-32.
10. Hiroyuki M, Kinoshita M, Fukuyama. Antioxidant xanthones from Garcinia subelliptica.
Phytochemistry. 1994;36(2):501.
11. Likhitwitayawuid K, Phadungcharo, Krunkrai J. Antimalarial xanthones from Garcinia dulcis. Planta
Medica. 1998;64:281-82.
12. Winter R, Ignatuschechenco M, Olumide. Potentiation of an antimalarial oxidant drug. antimicrobial agents and chemotherapy. 1997;47(7): 1449-54.
How to Cite
SYAMSUDIN, Syamsudin.
Stres Oksidatif di dalam Model Kerja Obat Antimalaria.
JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 4, n. 1, p. 48-50, apr. 2006.
ISSN 2614-6495.
Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/605>. Date accessed: 30 may 2023.
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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
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