Produksi Senyawa Kuinina dengan Fermentasi Mikroba Endofit Tanaman Cinchona pubescens Vahl.

  • Esti Mumpuni Universitas Pancasila
  • Herman Suryadi FMIPA Departemen Farmasi Universitas Indonesia
  • Partomuan Simanjuntak Pusat Penelitian Bioteknologi-LIPI

Abstract

This study deals with endophytic microbes, known as a potential source of secondary metabolites. The microbes (F) were isolated from Cinchona pubescens Vahl and fermented in Phoma media, observing the pH, biomass growth and secondary metabolites of alkaloids for 14 days. The result obtained showed that the pH was between 4 and 5, the biomass growth relative stable after 8 days and the production of alkaloids reached its maximum also after 8 days (32.81 mg/l).

References

1. Barnet J A, et al. Yeast, Characteristics and identifications, 2nd ed. Cambridge: Cambridge University Press; 1990.p.15-23,614-8.

2. Gringauz A. Introduction to medicinal chemistry. New York: Wiley VCH; 1996.p. 276-8.

3. Simanjuntak. P, dkk. Produksi alkaloid kuinina oleh beberapa mikroba endofit dengan penambahan zat
induser. Majalah Farmasi Indonesia. 2002.

4. Skoog DA, Leavy. Principles of instrumental analysis, 4th Ed. London: A Harcourt Brace
Javanovich College Publisher; 1990.p.77-252.

5. Song Y. Isolation and cultivation of endophytic fungi, asian network on microbial researches. Yogyakarta:
Gadjah Mada University; 1998.

6. Stierle A, Strobel G.A. The research for taxol – producing microorganism among the endophytic fungi of the pacific yew Taxus brevifolia. Journal of Natural Product. 1995;1315-1324.

7. Strobel GA. Endophytic fungi. New Sources for Old and New Pharmaceuticals. Pharmaceuticals News.
1996;(3):7-9.

8. Sumali Wiryowidagdo, Kimia dan farmakologi bahan alam, Jakarta: DirJen DIKTI; 2002. hal.282-8.

9. Tierney LM. Current medicinal diagnosis and treatment, 39th ed. New York: Lange Medicinal Book; 2002.p.1419–26.

10. Wolff EM. Burger's medicinal chemistry and drug discovery, 5th ed. New York: John Willey & Sons Inc; 1997.p. 4-75

11. Verpoorte R, et al, The alkaloids, Vol. 34. New York: Academic Press, 1988.p.331-6.
Published
2005-09-25
How to Cite
MUMPUNI, Esti; SURYADI, Herman; SIMANJUNTAK, Partomuan. Produksi Senyawa Kuinina dengan Fermentasi Mikroba Endofit Tanaman Cinchona pubescens Vahl.. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 3, n. 2, p. 56-59, sep. 2005. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/607>. Date accessed: 22 dec. 2024.
Citation Formats
Issue
Vol 3 No 2 (2005): JIFI
Section
Articles

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.