Pengaruh Iradiasi Sinar Gamma dan Konsentrasi Kitosan terhadap Pembentukan Hidrogel Polivinil Alkohol-Kitosan
Abstract
Chitosan is one of the product from the shrimp disposal. Its medicinal and pharmaceutics application are now developed by pharmaceutical industries, i.e as bioplastics and hydrogel. A research about the effect of gamma radiation and chitosan as a raw material for production of polyvinilalcohol has been carried out. PVA-chitosan hydrogel was made from a mixture of composition of 80% PVA in 10% solution and 20% of chitosan in 0, 1, 2 ,and 3% solution respectively. The mixture was heated in oven at 80°C for two hours and then irradiated with 0, 15, 25, and 35 kGy gamma radiation. The physical characteristic of the gel was determined, e.g. colour, swelling degree and gel fraction. The colour of hydrogel more yellow darker to raising of chitosan concentration and radiation dosage. Swelling degree PVA-chitosan hydrogel increased meanwhile chitosan concentration and radiation dosage decreased. In absolute ethanol medium (96%) PVA-chitosan hydrogel was deswelling. The swelling degree PVAchitosan hydrogel decreased with increased gel fraction.
References
2. Himayanti. Pengaruh iradiasi sinar gamma pada kulit udang putih (Penaeus merquensis) dalam pembuatan kitosan dari kitin. [skripsi). Jakarta: Fakultas Farmasi Universitas Pancasila; 2001. hal. 1, 34-5, 43-4.
3. Binh Doan. Research and development activities on radiation processing of chitin/chitosan, alginates, and starch in Vietnam. Hochiminh, Vietnam: Research and Development Center for Radiation Technology; 2001. hal.1-3.
4. Tokura Seiichi, Nishi Norio. Specification and characterization of chitin and chitosan. Environmentally Friendly Modern Materials; 1995. hal.1-2.
5. Canh TT. Radiation processing of chitin-chitosan.Vietnam Atomic Energy Commision. hal.1-11.
6. Zainuddin K. Modifikasi hidrogel polivinil alkohol dengan teknik radiasi [tesis]. BATAN; 1994. hal.208214.
7. Koswara B. Stok udang jerbung (Penaeus merguiensis de Man) di perairan Cirebon dan alternatif pengelolaannya [disertasi]. Bogor: Fakultas Pasca Sarjana Institut Pertanian Bogor; 1985. hal.7-8.
8. Mudjiman A. Budidaya udang windu. Cetakan I. Jakarta: P.T. Penebar Swadaya; 1982. hal.5.
9. Chaudari CV. Radiation processing of natural polymer. Mumbai, India: Bhabha Atomic Research Centre. hal.1
10. Teguh DO. Analisis film bioplastik dari kitosan hasil iradiasi kitin yang berasal dari kulit kepiting bakau (Scylla serrata). [skripsi). Jakarta: Fakultas Farmasi Universitas Pancasila; 2002. hal. 44.
11. Wade A, Weller PJ, editors. Handbook of pharmaceutical excipients. Second edition. London:
The Pharmaceutical Press, 1994. hal.383-4.
12. Departemen Kesehatan Republik Indonesia. Farmakope Indonesia. Edisi IV. Jakarta: Direktorat Jenderal Pengawasan Obat dan Makanan; 1995. hal.1193.
13. Dewi L. Sintesis dan pengujian fraksi gel, pengaruh suhu, pH, pengamatan pori, imobilisasi, serta pelepasan kloramfenikol dari hidrogel hidroksi etil metakrilat-ko-N-vinil pirolidon [skripsi). Jakarta: Fakultas Farmasi Universitas Pancasila; 1999. hal.21.
14. Richardson TL. Industrial plastics: theory and application. Delmar: Publishers Inc; 1989. hal.414.
15. Hien NQ. Radiation modification of polysaccharides. Ho Chi Minh, Vietnam, 2000. hal.1-4.
16. Rosiak JM. Radiation effect on polymer. Washington D.C:ACS; 1991. hal.118.
17. Skoog DA, Leary JJ. Principles of instrumental analysis. 4th edition. Fort Worth: A Harcourt Brace Jovanovich College Publisher; 1992. hal.252-288.
18. Huglin MB and Mat Z. Swelling properties of copolymer hydrogel preparation by gamma iradiation. Journal of applied polymer scien. 1986;3:457.
19. Martin A, Swarbick J, Cammarata A. Farmasi fisik: dasar-dasar farmasi fisik dalam ilmu farmasetik. Edisi III. Jilid II. Diterjemahkan oleh Yoshita. Jakarta: UIPress; 1993.hal.1170-4.
20. Erizal. Sintesis dan karakterisasi hidrogel hasil iradiasi. Jakarta: BATAN; 1999. hal.11,17.
21. Park K, Shalaby WSW, Park H. Biodegradable hidrogels for drugs delivery. Cetakan ke-10. Lancaster, Pennsylvania: Technomic Publishing CO, INC; 1993. hal.88.
Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.
This licence applies to Author(s) and Public Reader means that the users mays :
- SHARE:
copy and redistribute the article in any medium or format - ADAPT:
remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication) - ALIKE:
If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original. - NO ADDITIONAL RESTRICTIONS:
You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
It does however mean that when you use it you must:
- ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
You may not:
- NONCOMMERCIAL: You may not use the article for commercial purposes.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Tools
