Aplikasi Metode Aktivasi Netron untuk Penetapan Mineral Selenium dalam Produk Suplemen Kesehatan

  • Titiek Martati Universitas Pancasila
  • June Mellawati Universitas Pancasila

Abstract

Recently, there are some health supplement products that are useful as an antioxidant in the market, and one of them is Selenium (Se) tablet. Therefore issue of falsification of drug due to the control of health supplement product become very important. In this research the determination of Se in health supplement tablet using neutron activation analysis has been carried out. Sample was irradiated using thermal neutron with 1013 neutron cm-?secondfluxes within 15 minutes, and based on n, y reaction 75Se isotope would be formed that could identified using Gamma spectrometer on 136, 264, and 279 keV energies. The result showed that neutron activation analysis method can analysis Se mineral that contained in health supplement tablet with accuracy ranged between 101.81 – 102.29 % and precision 99.02 -99.37%. The recovery test of Se mineral concentration to the labeled attached showed 105.79 - 116.66%, and this value was still in the recommended range according to the USP 28 (90 – 125%).

References

1. Tim Vitahealth. Seluk beluk food supplement. Jakarta: Gramedia Pustaka Utama; 2004. hal.11-130.

2. Mohamad K. 2005. Obat palsu. diambil dari http:// www.kompas.com/kompas-cetak 70509/ 24/ opini/ 2073152.htm. diakses 29 Januari, 2005.

3. Lebih dekat dengan antioksidan. diambil dari http://www.kompas.com. diakses 14 Maret, 2005.

4. United States Pharmacopeia Convention. The United States pharmacopeia 28-The National Formulary 23. Rockville: United States Pharmacopeia Convention Inc; 2005. hal.21.

5. Badan Pengawas Obat dan Makanan. Petunjuk operasional penerapan cara pembuatan obat yang baik. Jakarta: Badan Pengawas Obat dan Makanan; 2001. hal. 19-423.

6. O'Neil M. The merck index. Thirthteenth Edition. USA: Merck & CO Inc; 2001.hal.1512.

7. Departemen Kesehatan Republik Indonesia. Farmakope Indonesia. Edisi IV. Jakarta: Direktorat Jendral Pengawasan Obat dan Makanan; 1995. hal.1195.

8. Pinta M. Modern methods for trace element analysis. Michigan: Ann Arbor Sciene; 1978. hal.7, 387.

9. International Atomic Energy Agency (IAEA). Practical aspects of operating a neutron activation
analysis laboratory. Viena: IAEA; 1990. p.7,206.

10. United States Pharmacopeia Convention. The United States pharmacopeia 28-the national formulary 23. Rockville: United States Pharmacopeia Convention Inc; 2005.p.2120.
How to Cite
MARTATI, Titiek; MELLAWATI, June. Aplikasi Metode Aktivasi Netron untuk Penetapan Mineral Selenium dalam Produk Suplemen Kesehatan. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 3, n. 2, p. 82-87, sep. 2005. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/612>. Date accessed: 05 nov. 2024.
Citation Formats
Issue
Vol 3 No 2 (2005): JIFI
Section
Articles

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.