Kemotaksonomi dan Farmakologi Tumbuhan Keluarga Guttiferae

Syamsudin Syamsudin

Syamsudin Syamsudin Universitas Pancasila

Abstract

The Guttiferae family has many species with interesting phytochemical properties. Is has been widely used in the traditional medicine and contains xanthones as constituent, exhibiting biological and pharmacological activities for example, e. g. as antimalaria, antimicrobe, antioxidant, anticancer and HIV-1 protease inhibitor.

References

1. Setiati, dkk. Sumber daya hayati Indonesia. Lembaga Biologi Nasional. Bogor: LIPI; 1997.

2. Kardono LBS. Studi pustaka tanaman Obat di Indonesia di Negara Industri. Warta Tumbuhan Obat. 1992; 1(3):26

3. Sweeney P. Mangosteen madnes. diambil dari http://www.mobot.org/MOBOT. research/mangosteen/. diakses 11 Februari, 2005.

4. Jensen SR, Srcripsema J. Chemotaxonomy and pharmacology in: gentianaceae-systematics and natural history. Editor: Strule L. Cambridge: Cambridge University Press; 2002. p.573 -613

5. Bennet G, Lee H. Xanthones from Guttiferae. Phytochemistry. 1989; 28(4): 967-998.

6. Likhitwitayawuid K, Phadungcharoen T, Krungkrai J. Antimalarial xanthones from Garcinia cowa. Planta Med. 1998b; 64: 70-72.

7. Likhitwitayawuid K, Chanmahasathien W, Ruangrungsi N, Krungkrai J. Xanthones with antimalarial activity from Garcinia dulcis. Planta Med. 19984; 64: 281-282.

8.Chi-kuan Ho, Yu-Huang, Chieh C. Garcione E,a Xanthone Derivatives, has potent cytotoxic Effect against hepatocellular Carcinoma Cell Lines. Planta Med. 2002;68: 975-79.

9. Matsumoto K, Akao Y, Kobayashi E. et al. Induction of apoptosis by xanthone from mangosteen in humanleukemia cell lines. J Nat Prod. 2003; 66(8): 1124

10. Minami H, Kinoshita M, Fukuyama et.al. Antioxidant xanthones from Garcinia subelliptica.
Phytochemistry. 1994; 36(2):501-6.

11. Williams P, Ongsakul M, Proudfoot J, Croft K, Beilin L. Mangostin inhibits the oxidative modification of human low density lipoprotein. Free Radic Res. 1995; 23(2): 175-84.

12. Suksamran S, Suwannapoch N, Phakhodee W et.al. Antimycrobial activity of prenylated xanthones from the fruits of Garcinia mangostana. Chem Pharm Bull. 2003; 51(7): 857-9.

13. Linuma M, Tosa H, Tanaka T et.al. Antibacterial activity of xanthones from guttiferaeous plants against methicillin resistant Staphylococcus aureus. J Pharm Pharmacol. 1996; 48 (8).861-5.

14. Chen SX, Wan M, Loh BN. Active constituents against HIV-Protease from Garcinia mangostana. Planta Med. 1996; 62(4): 381-2.

15. Chairungsriled N, Furukawa K, Ohta Nozoes, Ohizumi Y. Pharmacological properties of alpha mangostin ,a novel histamine H, receptor antagonist. Eur J Pharmaco. 1996; 314 (3): 351-6.

16. Nakatani K, Atsumi M, Arakawa T. et al. Inhibitions of histamine release and prostaglandin E, synthesis by mangosteen a Thai medicinal plant. Biol Pharm Bull. 2002;25(9): 1137-41.