Penghambatan Ekspresi Gen dengan Antisense Oligonukleotida sebagai Upaya Pengobatan Penyakit

  • Dian Ratih Laksmitawati Universitas Pancasila
  • Ani Retno Prijanti Fakultas Kedokteran Universitas Indonesia


Due to the development of biomolecular science eg. overexpression genes, genes that cause diseases can be identfied, Based on this fact, researchers developed a therapeutic strategy by inhibiting the gene expression using oligonucleotide antisense. Therapy using oligonucleotide antisense was based on a natural process of gene expression. Specific artificial antisense will match complementary with DNA and mRNA. By this process the transcription will stop. The effort of therapy is relatively new but a few have been carried out in the clinical trial phase. Obstacles are encountered in reaching the target cell by the oligonucleotide antisense.


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How to Cite
LAKSMITAWATI, Dian Ratih; PRIJANTI, Ani Retno. Penghambatan Ekspresi Gen dengan Antisense Oligonukleotida sebagai Upaya Pengobatan Penyakit. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 3, n. 2, p. 92-99, sep. 2005. ISSN 2614-6495. Available at: <>. Date accessed: 30 may 2023.