Efek Antioksidan dari Ekstrak Biji Petai Cina (Leucaena leucocephala L.) pada Tikus Putih

  • Fatty Nurhasanah Universitas Pancasila
  • Syamsudin Syamsudin Universitas Pancasila

Abstract

The study deals with the examination of the antioxidative effect of a Leucana leucocephala L. seed extract on diabetic rats induces with streptozotosin. The rats were divided in to 6 groups, each consisting of 5 rats i.e. group 1: normal, group 2: control (chlorpropamide), group 4: low dose of Laucaena seed extract 0,5/kg BW and group 6: high dose of Laucaena seed extract 1 g/kg BW. The malon dialdehyde (MDA) and superoxid dismutase (SOD) contents were analyzed by ANOVA and continued with the ttest. The result obtained shows that an increase of SOD could be observed by a Laucaena seed extract of resp 0.25;0.5 and 1 g/kg BW.

References

1. West IC. Radicals and oxidative stress in diabetes. Diabetic Medicine. 2000; 17:171-80.

2. Giugliano D, Ceriello A, Paulisso G. Oxidative stress and diabetic vascular Complications. Diabetic Care. 1996. 19(3):257-67.

3. Chowienczyck, Brett SE, Gopaul NK, Meecking D, Marchetti A, Russel J. Oral treatment with an oxydant reduce oxydative stress and improved endothelial function in men with type 2. Diabetologia. 2000. 43:947-77.

4. Baynes JW. Role of oxidative stressing the complications in diabetes. Diabetes. 1991; 40:405-12.

5. Hanan H, Syamsudin. Efek ekstrak biji petai cina Leucaena leucocephala terhadap profil lipid darah tikus diabetes NIDDM yg diinduksi dengan streptozotocin. Jurnal Ilmu Kefarmasian Indonesia. 2004;2(1):4-6.

6. Will ED. Evaluation of lipid peroxidation on lipid and biological membranes. Dalam: Biochemical Toxicology 5 thed. K Snell and B Mullock Press Oxford Washington DC; 1987.p.139.

7. Misra and Fridovich. The role of superoxide dismutase anion in the auto-oxidation of epinephrin and asimple assay for superoxide dismutase. Journal of Biochemical. 1972; 247(10):3170-75.

8. Schefler WC. Statistika untuk biologi Farmasi, Kedokteran dan ilmu yang Bertautan. Terbitan kedua. Diterjemahkan oleh Suroso, Bandung: ITB; 1987.p.107.

9. Halliwel B, Gutteridge JMC. Free radical in biology and medicine Third edition. New York: Oxford University Press, 1998.

10. Ling li. Streptozotocin in free radical and biology program. Iowa City: The University IOWA; 2001.p.3

11. Scalecsky E,Prechl J, Feher J, Somogy. Alteration in enzymatic antioxidant defence in diabetes mellitus. A rational approach. Post graduate Med Journal. 1999; 75:15-17

12. Syamsuhidayat S, S. Hutapea, JR. Inventaris tanaman obat Indonesia. Jakarta: Balai Penelitian dan Pengembangan Departemen Kesehatan RI; 1991.hal. 46-347.

13. Pari L, Latha M. Effect of Cassia auriculata Flowers on blood sugar levels, serum and tissue lipids in streptozotocin diabetic rats. Singapore Med Journal. 2002; 43(12): 620.

14. Anoja, Yun-Pin Zhow,Jing-Tian xie et.al. Antidiabetic effects of panax ginseng, berry extract and the identification of an effective component. Diabetes. 2002; 51:1851-58.

15. Bartosikova, Necas, Suchy R et al. Monitoring of antioxidative effect of Morine in alloxan-induced diabetes mellitus in the Laboratory Rats. ActaVet.BRNO. 2003; 72:91-200.
How to Cite
NURHASANAH, Fatty; SYAMSUDIN, Syamsudin. Efek Antioksidan dari Ekstrak Biji Petai Cina (Leucaena leucocephala L.) pada Tikus Putih. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 3, n. 1, p. 13-16, apr. 2005. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/619>. Date accessed: 03 july 2024.
Citation Formats
Issue
Vol 3 No 1 (2005): JIFI
Section
Articles

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.