Toksisitas Akut dan Khasiat Ekstrak Som Jawa (Talinum paniculatum Gaertn) sebagai Stimulan

  • Yun Astuti Nugroho Puslitbang Farmasi dan Obat Tradisonal Badan Litbangkes
  • Lucie Widowati Puslitbang Farmasi dan Obat Tradisonal Badan Litbangkes
  • Pudjiastuti Pudjiastuti Puslitbang Farmasi dan Obat Tradisonal Badan Litbangkes
  • Budi Nuratmi Puslitbang Farmasi dan Obat Tradisonal Badan Litbangkes

Abstract

Som Jawa (Talinum paniculatum Gaertn.) is a kind of Indonesian herbs that has similarities morphologically and chemically to Chinese ginseng. Som Jawa known as Ginseng Jawa in traditional healing has been made into various forms. The famous form is made as wine. The research on acute toxicity and efficacy test of Som Jawa as stimulant have been carried out to make Som Jawa into Indonesian Ginseng. The methodology of toxicity test is according to Weil CS (1952) and the efficacy test is according to Turner (1965). The test result showed that the value of acute toxicity of Som Jawa is 32.22 (25.59-40.56) mg/10 g BW (ip mice). At the time of starting to sleep, there was a significant difference on Som Jawa 10 mg/40g BW dose administration to Heptamyl 1.56 mg/40 g BW (p=0.00). In the swimming time extract of Som Jawa 5 and 10 mg/40 g BW showed no significant differences to Heptamyl 1.56 mg/40 g BW (p>0.05) (mean=32.88 +11.6;39.77 +14.6; 32.33 – 15.9). Som Jawa (Talinum paniculatum Gaertn.) is safe based on acute toxicity test. Extract of Som Jawa could prolong the time of starting to sleep and improve fitness.

References

1. Pansea. Manfaat gingseng dalam kedokteran modern. Panasea.1993.hal.62.

2. Hembing WK. Tanaman berkhasiat obat Indonesia. Jilid 3. Jakarta: Pustaka Kartini; 1994.hal.21-5.

3. Komatsu M. Studies on the constituens of Talinum paniculatum Gaertner. Yakugaku. Zasshi. 1982;
102(5).

4. Kartawinata S. Pengaruh biji kapas, pasak bumi, ginseng jawa, bawang putih, pegagan dan mangkokan terhadap libido tikus putih jantan. FF. UGM, 1991.

5. Widowati L, dkk. Khasiat infus Som Jawa terhadap susunan syaraf pusat. POKJANAS. TOI. XI.
Surabaya, 1996.

6. Harborne JB. Metoda fitokimia. Penentuan cara modern menganalisa tumbuhan. Ed.2. Terjemahan
Padmawinata. K dan Sudiro. Bandung: ITB; 1987.

7. Weil CS. Tables for convenient calculation of median effective dose and instructions in their use. Biometric. 1975.

8. Turner RA. Screening methods in pharmacology. Academic Press; 1965.

9. WHO. Penuntun laboratorium WHO untuk pemeriksaan semen manusia. FK UI; 1988.

10. Totowarso. Tehnik perancangan percobaan. Kelompok Statistika. Bandung: Fakultas Pertanian UNPAD; 1982.

11. Milton J. Statistical methods in the biology and health sciences. New York; 1991.

12. Daniel WW. Biostatistics: a foundation for analysis in the health sciences. 4th Ed. New York: John Wiley
& Sons; 1987.

13. Wahyuni S dan H. Endang. Karakteristik Talinum paniculatum Gaertn, dan Talinum triangulare Willd.
Warta TOI. 1999;5(4).

14. Tani T, et al. Histichemistry II. Ginsenosida in Ginseng (Panax ginseng, root). J Nat Prod. 1981; 44(4).

15. Sulistia, Gan, dkk. Farmakologi dan terapi. Jakarta: Bagian Farmakologi F UI; 1995.

16. Ganong WF. Buku ajar fisiologi kedokteran (Review medical physiology). 14th edition. Jakarta: EGC; 1992.
How to Cite
NUGROHO, Yun Astuti et al. Toksisitas Akut dan Khasiat Ekstrak Som Jawa (Talinum paniculatum Gaertn) sebagai Stimulan. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 3, n. 1, p. 17-20, apr. 2005. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/620>. Date accessed: 05 nov. 2024.
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