Mekanisme Kerja Obat Antimalaria

  • Syamsudin Syamsudin Universitas Pancasila


Malaria remains the most devastating infectious parasitic disease, inflicting both death and economic losses on at least half the world's population. Numerous attempts have been made to control the disease using vector control measures and/or chemoprophylaxis. Antimalarial drugs have a selective action on the different phases of the parasite life cycle. Mechanism of antimalarial drugs action will be discussed in this article.


1. WHO. The situation of malaria in the world. J Epid Week. 1977;72:269-92.

2. Abednego HM dan Suroso. Mosquito-borne disease. status and control in Indonesia. National Seminar on Mosquito-borne Disease By Molecular Approach. Yogyakarta: Pusat Kedokteran Tropis, FK UGM; 1988.

3. Tjitra E. Manifestasi klinis dan pengobatan malaria. Cermin Dunia Kedokteran. 1944; 94:5-13.

4. WHO. Tropical disease research. Malaria; 1985.

5. Fitch CD. Chloroquine resistance in malaria. Proc Natl Acad Sci USA. 1986; 64: 1181-87.

6. Krogstat DJ, Gluzman IY, Kyle DE et al. Efflux of chloroquine from Plasmodium falciparum mechanism of chloroquine resistance. Science. 1987; 238: 1283-85

7. Chwatt B, Black R, Canfield C, Cyde D, Peters, Wernsdorfer. Chemotherapy of malaria. WHO Geneva; 1986.p.24-45.

8. Hall AP. Treatment of malaria in: chemotherapy and Immunology In the control of malaria, filariasis and leishmaniasis. Nitya A: editor. Mc Graw-Hill Publishing Company; 1986.p.59-75.

9. Pradines B, Alibert S, Houdoin C et al. In vitro increase in chloroquine accumulation induced by dihydroethano and ethenoanthracene derivatives in Plasmodium falciparum- parasitized erythrocytes. Antimicrobial Agents and Chemotherapy. 2002.46(7).

10. Vyas N, Avery BA, Avery MA, and Wyandt CM. Carrier-mediated partitioning of artemisinin into Plasmodium falciparum-Infected Erythrocytes. Antimicrobial Agents and Chemotherapy. 2002. 46 (1).

11. Pandey AV, Tekwani BL, Singh RL and Chauh VS. Artemisin, an endoperoxide antimalarial disrupts the hemoglobin catabolism and heme detoxification systems in malarial parasite. Journal of Biol Chem 1999.274 (27)

12. Okpako DT. Principles of pharmacology. Cambridge University Press; 1991. p. 228-232.

13. Srivastava IK, Rottenberg H, and Vaidya AB. Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite. The American Society for Biochemistry and Molecular Biology, Inc. 1997. 272(14): 3961-66.

14. Nugroho A, Tumewu W. Siklus hidup plasmodium malaria. In: Malaria, Editor P.N.Harijanto. Penerbit Buku Kedokteran EGC; 2000.

15. Kisilevsky R, Crandall I, Szarek.WA. Bhat S, Tan C, Boudreau L, and Kevin C. Short-chain aliphatic polysulfonates inhibit the entry of Plasmodium into red blood cells. Antimicrobial Agents and Chemotherapy. 2002; 46: 2619-26.

16. Schlesinger P, Krogstad DJ, Herwald. Antimicrobial agents: mechanisms of action. Antimicrobial Agents and Chemotherapy. 1988. 32(6): 793-98.
How to Cite
SYAMSUDIN, Syamsudin. Mekanisme Kerja Obat Antimalaria. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 3, n. 1, p. 37-40, apr. 2005. ISSN 2614-6495. Available at: <>. Date accessed: 16 apr. 2024.