Isolasi, Elusidasi Struktur, dan Uji Bioaktivitas Alkaloid dari Akar Kemuning (Murraya exotica L.)

  • Bustanussalam Bustanussalam Pusat Penelitian Bioteknologi-LIPI
  • Titi Parwati Pusat Penelitian Bioteknologi-LIPI
  • Partomuan Simanjuntak Pusat Penelitian Bioteknologi-LIPI


Isolation and structure elucidation of an alkaloid, a bioactive compound from the roots of the Indonesian medicinal plant Kemuning, Murraya exotica (Rutaceae), including the brine shrimp lethality test (BSLT) have been carried out. The bioactivity test using Artemia salina, isolation and purification of the ethyl acetate extract performed by column chromatography gave yellow crystals. Based on ultraviolet, infrared, nuclear magnetic resonance (1H-&13C-NMR) and gas chromatographymass spectra the isolated bioactive compound is an indole alkaloid typical to yuehchukene.


1. Kong YC, Cheng KF, Combie RC and Waterman G. Yuehchukene: a novel indole alkaloid with antiimplantation activity. J Chem Soc Commun. 1985;4748.

2. Heyne K. Tumbuhan berguna Indonesia. Jilid II. Jakarta: Badan Litbang Kehutanan; 1987. hal. 1082-1083.

3. Kong YC. Yuehchukene, a novel antiimplantation indole alkaloid from Murraya paniculata. Planta Medica. 1985;45:304 – 307.

4. Meyer BN and Putnam JE. Brine shrimp: a convinient general bioassay for active compound constituents. Planta Medica. 1982;45:31 – 34.

5. Simanjuntak P dan Parwati T. Daya toksis beberapa tumbuhan obat tradisional Indonesia asal Nusa Tenggara Barat. Jurnal Biologi Indonesia. 1998;2(3):118-125.
How to Cite
BUSTANUSSALAM, Bustanussalam; PARWATI, Titi; SIMANJUNTAK, Partomuan. Isolasi, Elusidasi Struktur, dan Uji Bioaktivitas Alkaloid dari Akar Kemuning (Murraya exotica L.). JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 2, n. 2, p. 63-70, apr. 2004. ISSN 2614-6495. Available at: <>. Date accessed: 20 july 2024.