The Importance of Protein Binding in Drug Monitoring

  • Aluwi Nirwana Sani Universitas Pancasila

Abstract

Ikatan obat dengan protein dalam darah umumnya tidak mempengaruhi efek terapinya. Selama tidak ada pergeseran ikatan, akibat obat lain yang afinitasnya lebih besar terhadap protein atau perubahan kondisi pasien. Terjadinya pergeseran ikatan yang mengakibatkan peningkatan konsentrasi obat tidak terikat juga akan dikompensasi dengan peningkatan volume distribusi sehingga konsentrasi obat tidak terikat kembali normal. Akan tetapi dalam prosedur monitoring obat yang ditetapkan adalah konsentrasi oba total, sehingga salah interprestasi bisa terjadi.

References

1. Brikett DJ. Drug protein binding. Australian Prescriber. 1988;11(3):56-57.

2. Gibaldi M. Biopharmaceutics and clinical pharmacokinetics. Pennsylvania: Lea and Febiger;
1991. p. 156-286.

3. Young LY and Koda-Kimble MA. The clinical use of drug. 4th ed. Washington: Applied Therapeutics Inc.; 1990. p. 2, 12.

4. Svensson CK, Wooddruff MN, Lalka D. Influence of protein binding and use of unbound (free) drug concentrations. In: Evans, editors. Applied pharmacokinetics, principles of therapeutic drug monitoring. Washington: Applied Therapeutics Inc, Spokane Inc; 1986. p. 12-8.

5. Ehrnebo M, Odar-Cederlof I. Binding of phenobarbital, pentobarbital and diphenylhydantoin to blood cells and plasma proteins in healthy volunteers and uremic patients. Eur J Clin Pharmacol. 1975;8:445-53.

6. Evans et al. Principles of therapeutic monitoring. Applied pharmacokinetics. 3rd ed. Vancouver: 1999. p.21-44

7. Koch-Wesser, Seller EM. Binding of drug to serum albumin. N Engl J Med. 1976;294:311-6

8. Sheiner LD, Tozer TN. Clinical pharmacokinetics. The use of plasma concentration of drug. In: Mellmon & Morrelli, editors. Clinical pharmacology. 2nd ed. New York: Mc Millan Publishing; 1979. p. 71-109.

9. Bussey HI, Hoffman EW. A prospective evaluation of therapeutic drug monitoring. Ther Drug Monit. 1983;3:245-248.

10. Levy RH. Monitoring of free drug level. Determination of free concentration versus free fraction. Ther Drug Monit. 1983;5(3):243-244.
How to Cite
SANI, Aluwi Nirwana. The Importance of Protein Binding in Drug Monitoring. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 2, n. 2, p. 97-100, apr. 2004. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/635>. Date accessed: 25 apr. 2024.
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