• Aluwi Sani Universitas Pancasila


The concept and terminology of pharmacokinetics might be forgotten already by pharmacists. Therefore, the writer plans to present a series of article explaining the meaning and significant important pharmacokinetics terms. This article will deal with Clearance (CL) and Volume of Distribution (Vd), which are the two most important primary pharmacokinetic parameters. Other parameters such as t' and AUC are derived from these two parameters. Definition, function and measurement will be discussed in this article.


1. Herfindal ET, Goul DR. Clinical Pharmacokinetics. Texbook Of Therapeutics: Drug And Disease Management. 6th Ed. Baltimore;1996.

2. Koda Kimble MA. Et al. Clinical pharmacokinetics, applied therapeutics: The Clinical Use of Drug. 5th Ed. Vancouver;1992.

3. Bi┼čkett DJ. Clearance. Australian Prescriber;1988. Vol: 11. No:1. 12.

4. Tucket GT, Melmon K, Richardson J. Measurement of the renal clearance of drug. Br J Clin Pharm ;1981.Vol:12.

5. Wilkinson GR. Clearance approaches in pharmacology. Pharmacol Rev;1987.

6. Hewitt WR, Hook JB. The Renal excretion of drugs. In: Bridges VW, Chasseud LF, ed. Progress in Drug Metabolism. New York: Willey;1983. Vol: 7. Chap 1.
How to Cite
SANI, Aluwi. KLIREN DAN VOLUME DISTRIBUSI. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 1, n. 2, p. 78-81, sep. 2003. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/659>. Date accessed: 10 june 2023.