KLIREN DAN VOLUME DISTRIBUSI

  • Aluwi Sani Universitas Pancasila

Abstract

The concept and terminology of pharmacokinetics might be forgotten already by pharmacists. Therefore, the writer plans to present a series of article explaining the meaning and significant important pharmacokinetics terms. This article will deal with Clearance (CL) and Volume of Distribution (Vd), which are the two most important primary pharmacokinetic parameters. Other parameters such as t' and AUC are derived from these two parameters. Definition, function and measurement will be discussed in this article.

References

1. Herfindal ET, Goul DR. Clinical Pharmacokinetics. Texbook Of Therapeutics: Drug And Disease Management. 6th Ed. Baltimore;1996.

2. Koda Kimble MA. Et al. Clinical pharmacokinetics, applied therapeutics: The Clinical Use of Drug. 5th Ed. Vancouver;1992.

3. Bişkett DJ. Clearance. Australian Prescriber;1988. Vol: 11. No:1. 12.

4. Tucket GT, Melmon K, Richardson J. Measurement of the renal clearance of drug. Br J Clin Pharm ;1981.Vol:12.

5. Wilkinson GR. Clearance approaches in pharmacology. Pharmacol Rev;1987.

6. Hewitt WR, Hook JB. The Renal excretion of drugs. In: Bridges VW, Chasseud LF, ed. Progress in Drug Metabolism. New York: Willey;1983. Vol: 7. Chap 1.
How to Cite
SANI, Aluwi. KLIREN DAN VOLUME DISTRIBUSI. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 1, n. 2, p. 78-81, sep. 2003. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/659>. Date accessed: 19 apr. 2024.
Citation Formats
Issue
Vol 1 No 2 (2003): JIFI
Section
Articles

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.