(Formulation and In Vitro Penetration Evaluation of Transfersome Gel Preparation Contains Caffeine as an Anticellulite)

  • RINI SUGIYATI UNIVERSITAS INDONESIA
  • ISKANDARSYAH ISKANDARSYAH UNIVERSITAS INDONESIA
  • JOSHITA DJAJADISASTRA UNIVERSITAS INDONESIA

Abstrak

Transfersome is a nano-vesicle which is deformable so it can penetrate to the deeper layer of skin. Caffeine is common used as an anticellulite. The aim of this study is to formulate and investigate in vitro penetration of caffeine from transfersome gel compared to nontransfersome gel. Four transfersome formulations with different caffeine concentrations (1; 2; 3; 5%) were made using thin layer hidration method. The fourth formulation was chosen to be loaded into gel (vesicle size of 202.35 nm ; polydispersity index of 0.1090 ; entrapment efficiency of 58.91%). The in vitro penetration evaluation was determined using Franz diffusion cell. The cumulative amount of caffeine penetrated from transfersome gel is 1218.34+358.71 μg cm-2, cumulative amount percentage is 8.53+2.55% and flux is 360.91+86.50 μg cm-2 hr-1. Those results gave higher value than that of nontransfersome gel (cumulative amount of 369.29+231.57 μg cm-2; cumulative amount of 2.61+1.37% ; flux 70.96+73.39 μg cm-2 hr-1). Accordingly, caffeine transfersome gel has better penetration than caffeine nontransfersome gel.

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KEMENKES RI

Diterbitkan
2017-09-23
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SUGIYATI, RINI; ISKANDARSYAH, ISKANDARSYAH; DJAJADISASTRA, JOSHITA. (Formulation and In Vitro Penetration Evaluation of Transfersome Gel Preparation Contains Caffeine as an Anticellulite). JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 13, n. 2, p. 131-136, sep. 2017. ISSN 2614-6495. Tersedia pada: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/68>. Tanggal Akses: 31 mar. 2025
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Terbitan
Vol 13 No 2 (2015): JIFI
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