Formula Optimation of Sunflower Oil Cream Formula

  • Eva Husein Universitas Sanata Dharma
  • Agatha Budi Susiana lestari Universitas Sanata Dharma


Sunflower oil is one of the components of moisturizing cream that keeps the moisture of the skin. To produce a good quality cream, it is necessary to select appropriate emulsifying agent. This study aims to find the optimum composition between Tween 80 and Span 80 as an emulsifying agent in the preparation of sunflower oil cream, to meet physical properties and physical stability in terms of viscosity, spread ability and viscosity shift for 30 days. The ability of the cream to maintain skin moisture was tested using the Transepidermal Water Loss (TEWL) method. This study used a 22 experimental research design with the Simplex Lattice Design. The results showed there are 3 formulas of Tween 80 and Span 80 in proportion (6:4)%, (7;3)% and (8:2)% that fulfill the requirements with 143,3-153,3 dPas in viscosity, spread ability in range 5,0-5,3 cm, and viscosity shift between 4,3-6,8%. Based on TEWL test, the optimum formula obtained has a moisturizing effect with a TEWL value 17,9-38,0%. It conclude, sunflower oil could be formulated into moisturizing cream using combination of Tween 80 and Span 80 in proportion (6:4)%, (7;3)% and (8:2)% to fulfill the requirements for 30 days and could keep the skin moisture.


1. Cooke A, Cork MJ, Victor S, Campbell M, Danby S, Chittock J, Lavender T. Olive oil, sunflower oil or no oil for baby dry skin or massage: a pilot, assessor-blinded, randomized controlled trial (the oil in baby skincare [observe study). Acta Derm Venereol. 2016. 96:323–30.

2. Eichenfield LF, McCollum A, and Msika P. The benefits of sunflower oleodistillate (SOD) in pediatric dermatology. Pediatric Dermatology. 2009. 26(6):669-75

3. Rowe RC, Sheskey PJ, and Quinn ME. Handbook of pharmaceutical excipients. Pharmaceutical Press. 2009.

4. Kim, Cherng-ju. Advanced pharmaceutics: physicochemical principles. CRC Press LLC, Florida. 2005. 214-35.

5. Gupta V, Nagpal M, Aggarwal G, Kaur R, Singh S, Behl T, Jain UK. Formulation, development, and evaluation of non-ionic surfactant based organogel for transdermal delivery of acyclovir, International Journal of Innovative Pharmaceutical Sciences and Research. 2014. 2(7)1297- 310.

6. Bolton S. and Bon C. Pharmaceutical statistic practical and clinical applications, 4thed. Marcel Dekker, Inc. New York. 2004. 523-24.

7. Patzelt A, Lademann J, Richter H, Darvin ME, Schanzer S, Thiede G. Sterry W, Vergou T, Hauser M. In vivo investigations on the penetration of various oils and their influence on the skin barrier. Skin Research and Technology. 2011.18:364–69.

8. Patel RP, and Kamani R. Formulation optimization and evaluation of mometasone furoate cream. Journal of Pharmacy Research. 2009. 2(10):1565-69.

9. Sinko JP. Martin’s physical pharmacy and pharmaceutical science: physical chemical and biopharmaceutical principles in the pharmaceutical science. 6thed. Lippincott Williams & Wilkins, Philadelphia. 2011. 767, 800, 816-18.

10. Xenograf OC, Wisudyaningsih B, Muslichah S, Hidayat MA. Formulasi dan penentuan stress testing sediaan krim M/A dan A/M ekstrak etanol edamame (Glycine max). Jurnal Pustaka Kesehatan. 2015. 3(3):426.

11. Garg A, Aggarwal D, Garg S, and Singla AK. Spreading of semisolid formulations : an update. Pharmaceutical Technology. 2002. 84-105.
How to Cite
HUSEIN, Eva; LESTARI, Agatha Budi Susiana. Formula Optimation of Sunflower Oil Cream Formula. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 17, n. 1, p. 62-67, apr. 2019. ISSN 2614-6495. Available at: <>. Date accessed: 25 feb. 2024. doi: