Sodium Alginat as a Mucoadhesive Polymer and The Effect Of Strength and Release Amoxicillin Granule

  • Yudi Srifiana Fakultas Farmasi dan Sains Universitas Muhammadiyah Prof.DR.HAMKA
  • Ari Widayanti Fakultas Farmasi dan Sains Universitas Muhammadiyah Prof. DR. HAMKA
  • Nopriadi Nopriadi Fakultas Farmasi dan Sains Universitas Muhammadiyah Prof. DR. HAMKA
DOI: https://doi.org/10.35814/jifi.v17i1.683

Abstract

Mucoadhesive is a bioadhesive dosage form which forms a bond with mucous membranes. Mucoadhesive dosage forms stayed on mucous membranes in prolonged time so can increase bioavailability. This study intended to determine the effect of sodium alginate as bioadhesive polymer to mucoadhesive strength of granules. The granules prepared using amoxicillin as active agent and sodium alginate as bioadhesive polymer by wet granulation method. Granule evaluation are moisture content, particle size, wash off test using rat stomach and dissolution test. Test results of total recovery F1, F2, F3, F4, F5, 540 mg, 560 mg, 580 mg, 600 mg, 620 mg. Test results of flow rate 10,78-11,75 g/second, and angle of repose 33,50-35,15°, test of particle size distribution in the range of 1410-1680 µm, moisture content  from 11.07 to 13.57%, wash off test of F1, F2, F3, F4 and F5 as consecutively 12.67, 14.00, 18.67, 26.00 and 33.33%. 2-way ANOVA test to % dissolution and wash-off test results sig. <0.05, so there is a significant difference between formulas. Based on the results showed that increasing concentration of sodium alginate increase mucoadhesive strength of granules but less able to resist of drug release, and the best formula is F3 that containing sodium alginate 580 mg.

References

1. Hoffman A, Qadri BA. 2007. Gastro-Retentive System. Dalam: Encyclopedia of Pharmaceutical Technology third edition volume 1. Hlm. 1850-1859

2. Sweetman, C.S. 2009. Martindale The Complete Drug Reference. 36th ed. Pharmaceutical Press. USA.

3. Sherwood L. 1996. Fisiologi Manusia: dari Sel ke Sistem edisi 2, Terjemahan: Brahm U Pendit. Penerbit Buku Kedokteran EGC. Jakarta. Hlm. 560

4. Lenaert V, Gurry R. 1999. Bioadhesive Drug Delivery System. Crc Pres, Bocca Raton. Florida. Hlm. 43-63

5. Rowe R, Sheskey P, Owen S. 2006. Handbook of Pharmaceutical Excipients 5th ed. Pharmaceutical Press. London. Hlm. 389-394, 656-657

6. Widayanti A. 2011. Pengembangan Formula Sediaan Lepas Lambat Nifedipin Dengan Sistem Mukoadhesif. Dalam: Tesis. Hlm 35

7. Ansel HC. 1989. Pengantar Bentuk Sediaan Farmasi, Terjemahan: Farida Ibrahim. UI Press. Jakarta. Hlm. 97, 118-120, 153, 217, 235

8. Banakar UV.1992. Pharmaceutical Dissolution Testing. Marcell Dekker and Sons inc. New York. Hlm. 139-177

9. Faizatun, Sofiah S, Riyana Y. 2007. Formulasi Tablet Matriks Mukoadhesif Diltiazem Hidroklorida Menggunakan Hidroksi Propil Metil Selulosa dan Carbopol 940. Dalam: Jurnal Ilmu Kefarmasian Indonesia. Hlm. 53-58

10. Lachman L, Lieberman HA Kanig JL. 1994. Teori dan praktek farmasi industri. Edisi III. Terjemahan: Suyatmi S. UI Press. Jakarta. Hlm. 643, 680, 690, 707

11. Deshpande A, Shah N, Rhodes C, Malick A. 1996. Controlled-Release Drug Delivery Systems for Prolonged Gastric Residence: An overview. Drug Dev. Ind. Pharm. Hlm. 531-539

12. Ririn, Attamimi. F., Nurlina, An Nur. S. 2013. Pengembangan Granul Gastromukoadhesif Amoksisilin Menggunakan Gum arab, Tragakan dan Xanthan gum serta uji pelepasan secara in vitro. Dalam: Majalah Farmasi dan Farmakologi, Vol 17, no.1. Hlm. 25-30

13. Departemen Kesehatan RI. 1995. Farmakope Indonesia. Edisi IV. Jakarta: Direktorat Jendral Pengawasan Obat dan Makanan; Hlm. 95-97, 488-489, 1083-1084

14. Indrawati T, Agoes G, Yulinah E, Cahyati Y. 2005. Uji daya Lekat Mukoadesif In Vitro beberapa Eksipient Polimer Tunggal dan Kombinasinya Pada Lambung dan Usus Tikus. Dalam: Jurnal Matematika dan Sains Vol 10 No 2. Hlm. 45-51

15. Fudholi A. 2013. Disolusi dan pelepasan obat in vitro. Pustaka pelajar. Yogyakarta. Hlm. 27, 137-154
Published
2019-04-24
How to Cite
SRIFIANA, Yudi; WIDAYANTI, Ari; NOPRIADI, Nopriadi. Sodium Alginat as a Mucoadhesive Polymer and The Effect Of Strength and Release Amoxicillin Granule. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 17, n. 1, p. 56-61, apr. 2019. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/683>. Date accessed: 22 dec. 2024. doi: https://doi.org/10.35814/jifi.v17i1.683.
Citation Formats
Issue
Vol 17 No 1 (2019): JIFI
Section
Articles

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.