Formulation, Characterization and In Vitro Penetration Study of Resveratrol Solid Lipid Nanoparticles in Topical Cream
Abstrak
There are many target sites in the skin layer that will be demage as the cause of oxidative stress, including lipids, DNA and proteins. Oxidative damage of skin can be prevented by using topical antioxidant. Resveratrol is a polyphenol antioxidant from grape seed oil, shows a potent antioxidant activity that could be beneficial in skin protection from oxidative stress. The objective of this research was to develop solid lipid nanoparticles (SLNs) of resveratrol and to evaluate the potential of SLNs as nanovesicle to penentrate through the skin layer. The SLN of resveratrol was prepared by solvent emulsification method. The developed SLN resveratrol were characterized for particle size, polydispersity index, entrapment efficiency and morphology. Resveratrol loaded SLN with glyceryl monostearate 0.5% displayed spherical morphology with particle size of 334.4±8.95 nm, polydispersity index of 0.289±0.062, entrapment efficiency of 48.706±1.319% and zeta potential of –27.53±0.802 mV. In vitro permeation studies of cream enriched with SLN resveratrol 10% showed fluks 6.64±0.19 μg/cm2/hour while fluks of cream enriched with resveratrol alone was 6.09±0.84 μg/cm2/hour.
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