Prospect of Biduri [Calotropis gigantea (L.) W.T. Aiton] as Medicinal Plant

  • Meutia Faradilla Jurusan Farmasi Universitas Syiah Kuala
  • Hilda Maysarah Universitas Syiah Kuala

Abstract

Calotropis gigantea (L.) W.T. Aiton or known as Biduri in Indonesia has been used in traditional medicine as an anti-inflammatory, antitoxin and antipyretic. This plant is often found in hot and arid climates. Research on the potential of this plant has not been done much in Indonesia. This article aims to examine the potential of Biduri as a source of medicinal plants. The study was carried out by reviewing research literatures of the botanical plants both sourced from international and national journals. The results of the study indicate that various types of extracts from the biduri plant have therapeutic activities for further development. The phytochemical testing and isolation has also been carried out to look for active substances that play a role in the pharmacological activity being tested. Based on the studies that have been carried out, biduri plants have great potential to be researched and further developed to become one of the sources of medicinal plants in Indonesia.

References

1. K. Isao, Z. Ru-song, P. Jong Dae, B. Nam in, T. Yasuyuki, Y. Masayuki SH. NII-Electronic Library Service. Chem Pharm Bull. 1992;40(8):2007–13.

2. Habib MR, Aziz MA, Karim MR. Inhibition of Ehrlich’s ascites carcinoma by ethyl acetate extract from the flower of Calotropis gigantea L. in mice. J Appl Biomed [Internet]. 2010;8(1):47–54. Available from: http://dx.doi.org/10.2478/v10136-009-0007-7

3. Rajesh R, Raghavendra Gowda CD, Nataraju A, Dhananjaya BL, Kemparaju K, Vishwanath BS. Procoagulant activity of Calotropis gigantea latex associated with fibrin(ogen)olytic activity. Toxicon. 2005;46(1):84–92.

4. Nguyen KDH, Dang PH, Nguyen HX, Nguyen MTT, Awale S, Nguyen NT. Phytochemical and cytotoxic studies on the leaves of Calotropis gigantea. Bioorganic Med Chem Lett [Internet]. 2017;27(13):2902–6. Available from: http://dx.doi.org/10.1016/j.bmcl.2017.04.087

5. Chandrawat P, Sharma RA. The Genus Calotropis : An Overview on Bioactive Principles and their Bioefficacy. 2016;5(1):61–70.

6. Deshmukh PT, Fernandes J, Atul A, Toppo E. Wound healing activity of Calotropis gigantea root bark in rats. J Ethnopharmacol. 2009;125(1):178–81.

7. Meilawaty Z. Pemberian ekstrak metanolik getah biduri (Calotropis gigantea) terhadap Ketebalan Epitel Gingiva Tikus Wistar. Stomatognatic (JKG Unej). 2012;9(2):73–6.

8. Meilawaty Z. Sel Fibroblas Gingiva Tikus Wistar Pada Penyembuhan Luka. J Prodenta [Internet]. 2013;1(2):71–7. Available from: http://jprodenta.ub.ac.id/index.php/prodenta/article/view/24/26

9. Alam MA, Habib MR, Nikkon R, Rahman M, Karim MR. Antimicrobial Activity of Akanda (<i>Calotropis gigantea</i> L.) on Some Pathogenic Bacteria. Bangladesh J Sci Ind Res [Internet]. 2008;43(3):397–404.
Available from: http://www.banglajol.info/index.php/BJSIR/article/view/1156

10. Fiisyatirodiyah, H. Abdul, M.Roihatul HEK. Potensi Terapi Tunggal Antimalaria Ekstrak Etanol Akar Widuri. J Farma Sains. 2015;1(2):3–10.

11. Van Khang P, Zhang ZG, Meng YH, Guo DA, Liu X, Hu LH, et al. Cardenolides from the bark of Calotropis gigantea. Nat Prod Res [Internet]. 2014;28(15):1191–6. Available from: http://dx.doi.org/10.1016/j.steroids.2013.06.002

12. Muslikhah. PENGARUH EKSTRAK ETANOL DAUN WIDURI (Calotropis gigantea) TERHADAP GAMBARAN HISTOLOGIS FIBROSARKOMA PADA MENCIT JANTAN (Mus musculus) YANG DIINDUKSI 7,12-DIMETILBENZ(A)ANTRASENA (DMBA) SECARA IN VIVO. Malang: Jurusan Biologi Universitas Islam Negeri Maulana Malik; 2010. hal 59-70.

13. Habib MR, Karim MR. Evaluation of antitumour activity of Calotropis gigantea L. root bark against Ehrlich ascites carcinoma in Swiss albino mice. Asian Pac J Trop Med [Internet]. 2011;4(10):786–90. Available from: http://dx.doi.org/10.1016/S1995-7645(11)60194-6

14. Ghule SD, Vidyasagar G, Bhandari A, Sharma P, Gunjal AP. CNS activity of leaves extract of Calotropis gigantea. Asian Pacific J Trop Dis. 2014;4(S2):S902–5.

15. Khan IN, Sarker MMI, Ajrin M. Sedative and anxiolytic effects of ethanolic extract of Calotropis gigantea (Asclepiadaceae) leaves. Asian Pac J Trop Biomed [Internet]. 2014;4(Suppl 1):S400–4. Available from: http://linkinghub.elsevier.com/retrieve/pii/S2221169115303014

16. Parhira S, Zhu GY, Chen M, Bai LP, Jiang ZH. Cardenolides from Calotropis gigantea as potent inhibitors of hypoxia-inducible factor-1 transcriptional activity. J Ethnopharmacol [Internet]. 2016;194(October):930–6. Available from: http://dx.doi.org/10.1016/j.jep.2016.10.070

17. Pathak AK, Argal A. Analgesic activity of Calotropis gigantea flower. Fitoterapia. 2007;78(1):40–2.
Published
2019-10-29
How to Cite
FARADILLA, Meutia; MAYSARAH, Hilda. Prospect of Biduri [Calotropis gigantea (L.) W.T. Aiton] as Medicinal Plant. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 17, n. 2, p. 246-250, oct. 2019. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/710>. Date accessed: 03 july 2024.
Citation Formats
Issue
Vol 17 No 2 (2019): JIFI
Section
Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.