The Lipid Profile and Aorta Histopathology on Hyperlipidemic Rat by Giving Green Coffee Extract

  • Fransiska Maria Christianty Faculty of Pharmacy, University of Jember
  • Diana Holidah Fakultas Farmasi, Universitas Jember
  • Fifteen Aprila Fajrin Fakultas Farmasi, Universitas Jember
  • Monica Cinuradha Aura Salsabina Fakultas Farmasi, Universitas Jember
  • Andrean Roni Fakultas Farmasi, Universitas Jember


The high prevalence and risk of death from cardiovascular disease has led to the development of alternative treatments derived from nature. Green coffee has not undergone a roasting process. The product is claimed as a weight loser, even though the cardiovascular effects are still controversial. This study aim was to determine the impact of green coffee bean extract on rat lipid profiles and aortic histopathology. Green coffee bean extract made by a re-maceration method using 96% ethanol. Rats were induced with high-fat diet then treated with green coffee bean extract at a dose of 200; 400; and 800 mg/kg BB. Rats were sacrificed, blood was taken for lipid profile measurements and observations were made on histopathological preparations of rat aorta. The results showed that administration of green coffee bean extract (especially doses of 200 mg/kg BW) for 14 days in hyperlipidemic mice could significantly improve lipid profiles, except HDL levels. Microscopic observations showed that green coffee bean extract could enhance the rat aorta histopathology even though it did not match normal conditions. We can conclude that green coffee bean extract has potential effects to be developed as an alternative to traditional medicine that has antihyperlipidemic effects and cardiovascular protective effects.


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How to Cite
CHRISTIANTY, Fransiska Maria et al. The Lipid Profile and Aorta Histopathology on Hyperlipidemic Rat by Giving Green Coffee Extract. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 18, n. 1, p. 21-27, apr. 2020. ISSN 2614-6495. Available at: <>. Date accessed: 06 dec. 2023. doi: