Antidiarrheal Effect of Senggani Leaves Infusion (Melastoma malabathricum L.) in Swiss Webster Male Mice Induced by Oleum ricini

  • Nova Suliska Institut Teknologi Bandung
  • Thito Dwi Evrianto Program Studi Farmasi, Fakultas MIPA, Universitas Al Ghifari
  • Herlinda Herlinda Program Studi Farmasi, Fakultas MIPA, Universitas Al Ghifari
DOI: https://doi.org/10.35814/jifi.v17i2.733

Abstract

Diarrhea is a disorder of defecation more than 3 times a day with the consistency of liquid stool, blood and/or mucus. The plants that is used by the community for diarrhea is senggani (Melastoma malabathricum L.). This study aims to determine the antidiarrheal effects and dose of senggani leaves infusion in mice induced by Oleum ricini. Mice were grouped into 5 groups: the positive control group (diarrhea induction), the comparison group (loperamide), and senggani leaves infusion test group with a dose of 26 mg/kg bw, 52 mg/kg bw, and 104 mg/kg bw. Mice induced diarrhea with Oleum ricini, 30 minutes later the mice were given the samples, except the positive control group. The faecal frequency, weight, and consistency were measured every 30 minutes for 4 hours. Senggani leaves infusion group 52 mg/kg bw showed the frequency and faecal weight were significantly different compared to the positive control group (P <0.5) at 240 minutes observation. The faecal consistency of senggani leaves infusion groups 52 mg/kg bw tends to be normal at 240 minutes observation. Senggani leaves infusion 52 mg/kg bw showed the best antidiarrheal effect compared to senggani leaf infusion 26 mg/kg bw and 104 mg/kg bw in Oleum ricini-induced mice.

References

1. Kemenkes RI. Riset Kesehatan Dasar; RISKESDAS. Jakarta: Balitbang Kemenkes RI. 2013.

2. Kemenkes RI. Riset Kesehatan Dasar; RISKESDAS. Jakarta: Balitbang Kemenkes RI. 2018.

3. Purwanto, S. Uji aktivitas antibakteri fraksi aktif ekstrak etanol daun senggani (Melastoma malabathricum L) terhadap Escherichia Coli. Jurnal Ilmu Keperawatan Sriwijaya. 2015.2.

4. Hariana, A. 262 tumbuhan obat dan khasiatnya. Bogor: Penebar Swadaya; 2013.

5. Tangjitman, K., Wongsawad, C., Kamwong, K., Sukkho, T, dan Trisonthi, C. Ethnomedicinal plants used for digestive system disorders by the Karen of northern Thailand. Journal of Ethnobiology and Ethnomedicine. 2015. 11:27. DOI 10.1186/s13002-015-0011-9

6. Silalahi, M., Nisyawati, dan Pandiangan, D. Medicinal plants used by the Batak Toba Tribe in Peadundung Village, North Sumatra, Indonesia. Biodiversitas. 2019. 20(2): 510-525. DOI: 10.13057/biodiv/d200230

7. Joffry, M. D., N. J. Yob, M. S. Rofiee, M. M. R. Meor Mohd. Affandi, Z. Suhaili, F. Othman, Md. Akim, M. N. M. Desa, and Z. A. Zakaria. Melastoma malabathricum (L.) Smith Ethnomedicinal Uses, Chemical Constituents, and Pharmacological Properties: A review. Evidence-Based Complementary and Alternative Medicine. 2012. 2012:48. doi:10.1155/2012/258434.

8. https://www.asiamedicinalplants.info/melastoma-malabathricum-l/, diakses tanggal 10 September 2019.

9. M. Zakaria and M. A. Mohd, Traditional Malay Medicinal Plants, Fajar Bakti Sdn. Bhd., Kuala Lumpur, Malaysia. 1994.

10. Goodman & Gilman. Dasar Farmakologi Terapi. Editor Joel G Hardman, Lee E. Limbird, Konsultan Editor Alfred Goodman Gilman. Alih bahasa Tim Alih Bahasa Sekolah Farmasi ITB. Edisi 10. Volume 1. Jakarta: EGC; 2007.

11. Departemen Kesehatan Republik Indonesia, Sediaan Galenik. Jakarta: Depkes RI; 1986.

12. Rahardja K dan Tjay, H T. Obat-Obat Penting. Jakarta: Elex Media Komputindo; 2007.

13. Nurhalimah, H., Wijayanti, N., Widyaningsih, T.D. Efek antidiare ekstrak daun beluntas (Pluchea indica l.) terhadap mencit jantan yang diinduksi bakteri Salmonella thypimurium. Jurnal Pangan dan Agroindustri. 2015. 3(3): 1083-1094.

14. Sunilson J.A.J, Anandarajagopal K., Kumari, A, V, A, G, dan Mohan, S. Indian journal of pharmaceutical sciences. 2009. 7(16): 691-695.
Published
2019-10-29
How to Cite
SULISKA, Nova; EVRIANTO, Thito Dwi; HERLINDA, Herlinda. Antidiarrheal Effect of Senggani Leaves Infusion (Melastoma malabathricum L.) in Swiss Webster Male Mice Induced by Oleum ricini. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 17, n. 2, p. 126-131, oct. 2019. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/733>. Date accessed: 26 dec. 2024. doi: https://doi.org/10.35814/jifi.v17i2.733.
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Vol 17 No 2 (2019): JIFI
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Articles
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