Antiinflammatory Activity Test of Cocor Bebek Leaves (Kalanchoe pinnata L) Against Rat’s Feet (Rattus novergicus)

  • Andi Maulia Sekolah Tinggi Ilmu Farmasi Makassar
  • Ismail Ismail Sekolah Tinggi Ilmu Farmasi Makassar
  • Andi Tendriani Safitri Sekolah Tinggi Ilmu Farmasi Makassar
  • Ahmad Fadly Perdana Sekolah Tinggi Ilmu Farmasi Makassar
DOI: https://doi.org/10.35814/jifi.v18i2.738

Abstract

Cocor bebek leaves contain fl avanoids which have anti-infl ammatory power by inhibiting
prostaglandin synthesis by blocking the work of cyclooxygenase and inhibiting leukotriene by blocking
lipookigenase. Infl ammation is a local protective response caused by damage to tissue caused by physical
trauma, damaging chemicals, or microbiological substances. This study aims to determine the eff ect of
cocor bebek leaf extract as an anti-infl ammatory in leg edema of white mice (Rattus novergicus) with
2% carrageenan induction. In this test using the in vivo activity test method for white rats (Rattus
novergicus) which has been induced by carrageenan. The volume of the rat’s feet is measured using
a pletismometer. Rats were divided into fi ve groups, the fi rst group as negative control were given
diclofenac sodium gel, groups two, three, four were given ethanol extract of leaves of cocor bebek 200,
400 and 600 mg respectively, group fi ve as negative controls then calculated volume of feet. The results
obtained, extract of 400 mg better anti-infl ammatory eff ects.

References

1. Ramadhani, N., Sumiwi, S.A. Aktivitas antiinfl amasi
berbagai tanaman diduga berasal dari flavonoid.
Universitas Padjajaran : Sumedang; 2017.

2. Setia, A.I.D., Tjitaresmi, A. Aktivitas antiinfl amasi
dari berbagai tanaman : Sebuah Review. Fak. Farm.
Univ. Padjajaran Jatinangor Sumedang; 2016. 14, 10.

3. Ningsih, I.Y. Studi etnofarmasi penggunaan tumbuhan
obat oleh suku Tengger di Kabupaten Lumajang dan
Malang, Jawa Timur. Fak. Farm. Univ. Jember; 2016.
11.

4. Putri, S.A., Sutadipura, N., Roekmantara, T. Efek eksrak
etanol daun cocor bebek (Kalanchoe Pinnata L.) terhadap luka
sayat pada tikus jantan galur wistar. Fak. Kedokt. Universitas
Islam Bandung; 2015.

5. Maulidina I.P, T., Agustina, R., Rijai, L. Potensi
antipiretik ekstrak etanol daun cocor bebek (Kalanchoe
pinnata L.), Presented At The The 4th Mulawarman
Pharmaceuticals Conferences, Fakultas Farmasi,
Universitas Mulawarman, Samarinda; 2016.

6. Amiyati, L. Uji Aktivitas analgetik ekstrak etanol daun
cocor bebek terhadap mencit jantan galur swiss. Fak.
Kedokt. Univ. Tanjungpura: Pontianak; 2015. 18.

7. Ravi V., T. S. M. Saleem, S. S. Patel, .I. Raamamurthy,
and K. Gauthaman. Antilnflammatory effect of
methanolic extract of Solanum nigrurn Linn. Berries.
Inter. J. App. Res. Nat. Prod; 2009.

8. Linnet A,, P. G. Latha, M. M. Gincy, G. I. Anuja, S. R.
Suja, S. Shymal, et al. Anti-infl ammatory, analgesic,
and anti-lipid peroxidative eff ects of Rhaphidophora
pertusa (Roxb.) and Epipremnum pinnatum (Linn.)
Engl. aerial parts. Indian J. Nat. Prod.and Res; 2010
Published
2020-10-28
How to Cite
MAULIA, Andi et al. Antiinflammatory Activity Test of Cocor Bebek Leaves (Kalanchoe pinnata L) Against Rat’s Feet (Rattus novergicus). JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 18, n. 2, p. 164-168, oct. 2020. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/738>. Date accessed: 05 sep. 2025. doi: https://doi.org/10.35814/jifi.v18i2.738.
Citation Formats
Issue
Vol 18 No 2 (2020): JIFI
Section
Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.