Clinical Study Safety and Efficacy of Tablet Extract Compared to Hyperuricemia Herbs Aqueous Extract

  • Agus Triyono Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional Tawangmangu
  • Widhi Astana Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional Tawangmangu
  • Danang Ardianto Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional Tawangmangu
  • Fajar Novianto Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional Tawangmangu

Abstract

Hyperuricemia is a metabolic disorder that is often found in the community, and requires long-term
treatment. To determine the effi cacy and safety of the hyperuricemia herbs, clinical studies have been carried out on the effi cacy and safety of tablet preparations compared to boiled of the hyperuricemia herbs. The clinical study was conducted with an open label research design, randomized clinical study and parallel design. The study involved 55 subjects who had met the inclusion and exclusion criteria. Subjects were randomized and divided into groups of tablets or boiled with intervention for 28 days. The tablet group took tablets with a dose of 3x2 tablets per day and the boiled group drank infusion with a dose of 3 times a glass per day. Blood uric acid was examined at D0, D14 and D28. SGOT, SGPT, urea, and creatinine were examined at D0 and D28. The tablet reduced uric acid (7.74 mg/dL to 6.53 mg/dL) and the boiled reduced uric acid (7.93 mg/dL to 7.09 mg/dL). The administration of tablet preparations eliminates the clinical symptoms of swollen/pain of leg, swollen/pain of hand, stiff ness, pain and other symptoms at the deff erent time than boiled administration. The administration of both preparations for 28 days in the subjects did not increase the value of SGOT, SGPT, urea and creatinine and no symptoms of serious side eff ects were found.

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Published
2021-05-01
How to Cite
TRIYONO, Agus et al. Clinical Study Safety and Efficacy of Tablet Extract Compared to Hyperuricemia Herbs Aqueous Extract. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 19, n. 1, p. 139-146, may 2021. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/739>. Date accessed: 28 sep. 2021. doi: https://doi.org/10.35814/jifi.v19i1.739.
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Articles