Clinical Study Safety and Efficacy of Tablet Extract Compared to Hyperuricemia Herbs Aqueous Extract

  • Agus Triyono Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional Tawangmangu
  • Widhi Astana Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional Tawangmangu
  • Danang Ardianto Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional Tawangmangu
  • Fajar Novianto Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional Tawangmangu
DOI: https://doi.org/10.35814/jifi.v19i1.739

Abstract

Hyperuricemia is a metabolic disorder that is often found in the community, and requires long-term
treatment. To determine the effi cacy and safety of the hyperuricemia herbs, clinical studies have been carried out on the effi cacy and safety of tablet preparations compared to boiled of the hyperuricemia herbs. The clinical study was conducted with an open label research design, randomized clinical study and parallel design. The study involved 55 subjects who had met the inclusion and exclusion criteria. Subjects were randomized and divided into groups of tablets or boiled with intervention for 28 days. The tablet group took tablets with a dose of 3x2 tablets per day and the boiled group drank infusion with a dose of 3 times a glass per day. Blood uric acid was examined at D0, D14 and D28. SGOT, SGPT, urea, and creatinine were examined at D0 and D28. The tablet reduced uric acid (7.74 mg/dL to 6.53 mg/dL) and the boiled reduced uric acid (7.93 mg/dL to 7.09 mg/dL). The administration of tablet preparations eliminates the clinical symptoms of swollen/pain of leg, swollen/pain of hand, stiff ness, pain and other symptoms at the deff erent time than boiled administration. The administration of both preparations for 28 days in the subjects did not increase the value of SGOT, SGPT, urea and creatinine and no symptoms of serious side eff ects were found.

References

1. Lamb E, Newman JD and Price PC, ‘Kidney Function Test’ in Tietz Textbook of Clinical Chemistry and Molecular Diagnostic, eds. Burtis C, Ashwood RE and Bruns ED, fourth edition, Elseiver Saunders, 2006,p803-5.

2. 4. Signh V, Gomez VV, Swamy SG, ’Approach to a Case of Hyperuricemia’, in Indian J Aerospace Med, 2010, vol 54 (1), p 40-5.

3. Pokhrel, Yadaf, Jha, Parajuli, dan Pokharel. 2015. Estimation of Serum Acid in Cases of Hyperuricaemia and Gout. Journal Nepal Medicinal Association. Vol. 51 (181). Medical Journal Of Shree Birendra Hospital.

4. Muniroh, L., Martini, S., Nindya, T.S., dan Solfaine, R. “Minyak atsiri kunyit sebagai anti radang pada penderita gout artritis
dengan diet tinggi purin,” Makara,Kesehatan, Vol.14, No.2 (2010) 57-64.

5. Tjokorda RK. Buku Ajar Ilmu Penyakit Dalam Jilid II Edisi IV. Jakarta: IPD FKUI; Juni 2006.p.1203-1206

6. Handajani Sri, dkk., 2006. The Queen of Seeds: Potensi Agribisnis Komoditas Wijen. Yogyakarta

7. Hardono Joko. 1997. Obat tradisional dalam zaman teknologi. Majalah Kesehatan Masyarakat. 56 : 3-6.

8. Soenarta dan Arieska. 2005. Konsensus pengobatan hiperurisemia. Jakarta, Perhimpunan Hiperurisemia Indonesia.

9. Peraturan Menteri Kesehatan Republik Indonesia. Nomor: 003/MENKES/PER /I/ 2010 tentang Saintifikasi Jamu dalam Penelitian Berbasis Pelayanan Kesehatan. Jakarta. 2010.

10. Aziz SA and BC Ramadhan. 2013. Media and organic fertigation for growth and phytochemical properties of Stelechocarpus burahol in nursery. International Seminar Proceedings Forests & Medical Plants for Better Human Welfare. Bogor, 10-12 September 2013. Hlm. 200-204

11. Purwaningsih, Arif Rahman, Indah Purwantini. Antiheperuremic Activity of the Kepel (Stelechocarpus burahol (Bl.) Hook. F&TH) Leaves Extract and Xanthenne Oxidase Inhibitory Study. International Journal of Pharmacy and Pharmaceutical Sciences, 2010;2(1)

12. Purwantiningsih, I Purwantini dan D Santoso. 2011. Identification of standard parameters of kepel leaves Stelechocarpus burahol and the extract as raw material for antihyperuricemic medicaments. Asi an Journal of Pharmaceutical and Clinical Research 4 (1) : 149-153

13. Sutomo. 2008. Penurunan kadar asam urat darah ayam jantan broiller hiperurisemia oleh fraksi petroleum
eter daun kepel (Stelechocarpus burahol Hook.) Sain dan Terapan Kimia 2 (1) :14-22

14. Wardani, C.G.T. Potensi EkstrakTempuyung dan Meniran sebagaI Anti asam urat: Aktivitas Inhibitor terhadap Xantin Oksidase. 2008. Skripsi. Bogor: Institut Pertanian Bogor

15. Cendrianti F, dkk. 2014.Uji Aktivitas Antihiperurisemia Ekstrak n-Heksana, Etil Asetat, dan Etanol 70% Daun Tempuyung (Sonchus arvensis L.) pada Mencit Jantan Hiperurisemi.e-jurnal Pustaka Kesehatan. Vol 2 No 2 (2014). 205-210

16. Pertamawati & Hardhiyuna M. Uji Penghambatan Aktivitas Enzim Xantin Oksidase Terhadap Ekstrak Kulit Kayu Secang (Caesalpinia Sappan L.Kartika-Jurnal Ilmiah Farmasi, Des 2015, 3(2), 12-17

17. Ronald et al. 2004. Tinjauan Kilis Hasil Pemeriksaan Laboratorium. Jakarta: EGC

18. Khadka, J., Malla, P., 2009, The study of drug induced hepatotoxicity in ATT

19. Mc.Gilvery, R.W., dan Goldstein, G.W. (1996). Biokimia: Suatu Pendekatan Fungsional. Edisi Ketiga. Surabaya: Airlangga University Press. Halaman 925, 926 929.
Published
2021-04-30
How to Cite
TRIYONO, Agus et al. Clinical Study Safety and Efficacy of Tablet Extract Compared to Hyperuricemia Herbs Aqueous Extract. JURNAL ILMU KEFARMASIAN INDONESIA, [S.l.], v. 19, n. 1, p. 139-146, apr. 2021. ISSN 2614-6495. Available at: <http://jifi.farmasi.univpancasila.ac.id/index.php/jifi/article/view/739>. Date accessed: 24 nov. 2024. doi: https://doi.org/10.35814/jifi.v19i1.739.
Citation Formats
Issue
Vol 19 No 1 (2021): JIFI
Section
Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Licencing
All articles in Jurnal Ilmu Kefarmasian Indonesia are an open-access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License which permits unrestricted non-commercial used, distribution and reproduction in any medium.

This licence applies to Author(s) and Public Reader means that the users mays :

  • SHARE:
    copy and redistribute the article in any medium or format
  • ADAPT:
    remix, transform, and build upon the article (eg.: to produce a new research work and, possibly, a new publication)
  • ALIKE:
    If you remix, transform, or build upon the article, you must distribute your contributions under the same license as the original.
  • NO ADDITIONAL RESTRICTIONS:
    You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

It does however mean that when you use it you must:

  • ATTRIBUTION: You must give appropriate credit to both the Author(s) and the journal, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

You may not:

  • NONCOMMERCIAL: You may not use the article for commercial purposes.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.